Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085632 (apathy)
 4,089 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Compared to leukemia, malignant lymphoma and other hematogenous tumors, multiple myeloma rarely metastasizes to the central nervous system. Intracerebral metastasis without involvement of the cranium itself is rarer. We report a case of Ig-G k-type multiple myeloma with metastasis to the left frontal lobe extending to the right basal ganglia without involvement of the cranium. A 71-year-old male complained of exertional dyspnea and lumbago. His laboratory data revealed hyperproteinemia and an abnormal increase in Ig-G (6117mg/dl) in his serum. Serum protein immunoelectrophoresis revealed an IgG k-type band, and Bence-Jones protein was detected in his urine. MMPP, VMCP, VIPP and MP chemotherapy was given, and serum IgG level decreased to a normal range. 21 months after his first admission, incontinence, disorientation, gait disturbance and apathy developed. CT-scan showed an isodense lesion with massive edema in the left frontal lobe and right basal ganglia. On MRI, a Gd-DTPA enhancing lesion was detected extending from the left frontal to the opposite frontal lobe through the splenium. No abnormal skull punched out lesions were noted. Left frontal lobectomy was performed. Histopathology revealed plasmablastic myeloma cells with clear nucleole and eccentric nucleus in the cerebrum. He was diagnosed as having intracerebral metastasis of multiple myeloma without involvement of the cranium. Unfortunately, he died of pancytopenia and pneumonia. Our case suggests the possibility of metastasis via blood into the cerebrum.
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PMID:[A case of multiple myeloma with intracerebral metastasis]. 140 49

The economic implications of safety precautions in laboratory practice make compliance difficult especially for laboratories in countries with poor economies. However, economic factors are not the only determinants of a safe work environment. Worker's perception of health and safety also influence compliance with safety guidelines. This study was conducted to determine the attitude and practice of laboratory workers with regard to safety. A structured questionnaire was administered to laboratory workers in 10 clinical laboratories. The questionnaire inquired about the use of protective equipment, safe work practices and immunization status of workers. Another questionnaire sought information on safety codes, accident records and first aid facilities in each laboratory. Questionnaires were coded and analysed. Ninety out of 106 laboratory workers (85%) responded to the inquiry. Unsafe work practices such as eating or drinking in laboratories and mouth pipetting of biological samples were practised by 41% and 10% of workers, respectively. Ninety percent of workers used white coats while 64% used gloves when handling biological samples. None of these workers used goggles or face shields in the course of their work. Fifty-one percent had received immunisation against tuberculosis, 73% against tetanus and 16% against hepatitis B. Thirty-seven percent of senior staff and 72% of junior staff did not receive any formal safety training. Accident records and first aid facilities were absent in most laboratories. The commonest health problem reported by workers was low back pain. The poor coverage of hepatitis B immunization among health care workers in an endemic area is currently a cause for concern among medical and paramedical staff. There is a need for education programmes to increase awareness on safety. Occupational health workers in this setting face the challenge of promoting safe work practices among workers in the face of the lack of funding and apathy among poorly paid junior workers.
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PMID:Health and safety in clinical laboratory practice in Ibadan, Nigeria. 1049 49

Background. The contribution of apathy, frequently recognized in individuals with neurodegenerative diseases, to chronic low back pain (LBP) remains unclear. Objectives. To investigate levels of apathy and clinical outcomes in patients with chronic LBP treated with tramadol-acetaminophen. Methods. A retrospective case-control study involving 73 patients with chronic LBP (23 male, 50 female; mean age 71 years) treated with tramadol-acetaminophen (n = 36) and celecoxib (n = 37) was performed. All patients were assessed using the self-reported questionnaires. A mediation model was constructed using a bootstrapping method to evaluate the mediating effects of pain relief after treatment. Results. A total of 35 (55.6%) patients met the criteria for apathy. A four-week treatment regimen in the tramadol group conferred significant improvements in the Apathy scale and numerical rating scale but not in the Rolland-Morris Disability Questionnaire, Pain Disability Assessment Scale, or Pain Catastrophizing Scale. The depression component of the Hospital Anxiety and Depression Scale was lower in the tramadol group than in the celecoxib group. The mediation analysis found that the impact of tramadol-acetaminophen on the change in apathy was not mediated by the pain relief. Conclusions. Tramadol-acetaminophen was effective at reducing chronic LBP and conferred a prophylactic motivational effect in patients with chronic LBP.
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PMID:Effect of Tramadol/Acetaminophen on Motivation in Patients with Chronic Low Back Pain. 2744 26