Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085632 (apathy)
 4,089 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of a week old female baby, admitted because of apathy, hypothermia, dyspnea, jaundice and cyanosis is described. She had the characteristic phenotype of Turner's syndrome with normal karyotype. Signs of severe heart failure were present. Therapy with diuretics, digoxin, dopamine and mechanical ventilation were unsuccessful, and the patient died several hours after her admission. The anatomopathological examination revealed the presence of hypoplastic left heart syndrome with mitral atresia and aortic atresia, atrial septal defect, double outlet right ventricle, and a patent ductus arteriosus.
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PMID:Noonan's syndrome associated with hypoplastic left heart. 235 79

In order to examine the predictive value of risk factors for the Sudden Infant Death Syndrome (SIDS), we have interviewed the parents of 80 SIDS victims and 80 parents of a healthy control group. From these interviews a list of 24 clinical and behavioural symptoms was assembled which appeared to be associated with the risk for SIDS. Out of this list of 24 symptoms the average number of symptoms reported to be observable in SIDS victims was twice as large as the average number of symptoms reported for healthy controls. The following symptoms appeared markedly more often in SIDS victims than in the controls: difficulties in awakening the baby, shrill crying, apathy, few movements during sleep, and cyanosis. We have attempted to consider a possible bias in the report of the parents of deceased infants by the introduction of an "exaggeration factor". By application of Bayes' theorem the highest predictive probability, 2.7%, was found for difficulties in awakening the baby. This is approximately nine times the assumed a priori probability of SIDS of 0.3%. We conclude that behavioural risk factors have a low but still remarkable predictive probability. A behavioural pattern of apathy and sleepiness indicates risk with a high probability.
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PMID:The predictive value of behavioural risk factors for sudden infant death. 322 74

Thermal stress was induced experimentally in the hybrid pigs LW X L, weighing 45 to 52 kg. The trials were repeated in boxes heated to the temperature of 43 to 47 degrees C. The pigs were examined for the values of tremor, pH, partial pressure of carbon dioxide (pCO2), base excess (BE), buffer base (BB), standard and actual bicarbonate (SB and AB), total carbon dioxide (tCO2) and partial oxygen pressure in blood (pO2). Thermal stress caused marked tachycardia, polypnoea, higher body temperature, increased blood pH, reduction of partial carbon dioxide pressure. Respiratory alkalosis was accompanied by cardiovascular weakness, general excitation followed by apathy, cyanosis and dyspnoea.
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PMID:[The effect of heat stress on acid-base homeostasis in pigs]. 643 33

In a fattening pig herd comprising 80 animals 13 were affected with clinical manifest toxoplasmosis presumably due to cat feces in the food. Seven pigs died, one was killed in extremis. The clinical signs were anorexia, apathy, fever, cyanosis, dyspnoea and partly hind limb weakness. One pig that died 3 days after onset of clinical signs had widespread necroses in liver and lymphatic organs. Single tachyzoites were detected by immunoperoxidase technique. One pig dying on day 11 and another euthanatized the same day showed severe desquamative and interstitial pneumonia and marked non suppurative meningoencephalomyelitis as well as necrotic foci mostly infiltrated with mononuclear cells in liver, adrenals and lymphatic organs. In all affected organs toxoplasmas were demonstrated histologically and immunohistologically. Every 2 surviving pigs were killed 40 days and 20 weeks, respectively, after recovery. These animals had high antibody titers against toxoplasma gondii and showed severe non suppurative meningoencephalitis and toxoplasma cysts in the brain without preceding clinical signs. In the lymphatic organs a marked hyperplasia was observed.
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PMID:[Toxoplasmosis epizootic in a fattening swine herd]. 822 41

A 5-month-old, intact male ferret (Mustela putorius furo) was presented with apathy, tachypnea and exercise intolerance. On initial physical examination, tachypnea and cyanosis were the two primary clinical signs detected. The complete blood count also revealed a severe polycythemia, with lymphopenia, neutrophilia and eosinophilia. Further diagnostic imaging tests were performed. The thoracic radiographs revealed cardiomegaly and a diffuse alveolar pulmonary pattern. Consequently, an echocardiography was performed and showed an interventricular septal defect, pulmonic artery occlusion, overriding of the aorta and right ventricle hypertrophy. All abnormalities were compatible with a tetralogy of Fallot (TOF). As a treatment plan, a phlebotomy was performed and the ferret was posteriorly maintained with oxygen and fluid therapy. The following day, the hematocrit decreased 11% and the respiratory distress improved. Four days later, the ferret got clinically worse and was euthanized. A necropsy was performed and confirmed the presence of an extreme TOF with a diffused interstitial pneumonia secondary to Pneumocystis carinii. To the author's knowledge, this is the first report of an extreme tetralogy of Fallot with polycythemia in a ferret.
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PMID:Extreme Tetralogy of Fallot With Polycythemia in a Ferret (Mustela putorius furo). 2899 10