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Query: UMLS:C0085632 (apathy)
 4,089 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of this study is to clarify which psychiatric symptoms affect the results in the Wisconsin Card Sorting Test (WCST) in schizophrenic patients. In a six month period, we selected 29 schizophrenic volunteers in a large psychiatric teaching hospital in Taiwan according to DSM-III-R. The psychiatrists and psychologists collected basic data and evaluated every volunteer's psychiatric symptoms using the Positive and Negative Syndrome Scale (PANSS) and the computerized Wisconsin Card Sorting Test (WCST) in three days. Twenty-four schizophrenic volunteers completed all examinations. We used SPSS 7.0 for Windows for data analysis. The results showed significant, positive correspondence between the WCST categories (1) trial to complete first category and the respective PANSS categories(1) G15. Preoccupation. Furthermore, the results which used stepwise analysis multiple regression showed P3 halluciatory behavior, N4. apathetic/social withdrawal positive scales, and S5 grandiosity in the PANSS could predict categories completed in the WCST; disorientation, N2. emotional withdrawal, and Positive scales in the PANSS could predict Perseverative Responses in the WCST; N4, Apathetic/Social Withdrawal in the PANSS could predict Number of Errors, and Percent Conceptual Level Responses in the WCST. Furthermore, G15. Preoccupation in the PANSS could predict Trial to Complete First Category in the WCST. Only Positive scales in the subscales of the PANSS could predict the results of WCST.
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PMID:[The related factors between the positive and negative syndrome scale (PANSS) and the Wisconsin Card Sorting Test (WCST) in schizophrenic patients]. 971 35

The frontal lobes can be subdivided into major functional neuroanatomical domains, which, when injured, surgically destroyed, or reduced in activity or volume, give rise to signature pathological and psychiatric symptomology. A review of case reports and over 50 years of research, including magnetic resonance imaging, positron emission tomography, and single photon emission computed tomography scans, indicates that apathy, "blunted" schizophrenia, major depression, and aphasic-perseverative disturbance of speech and thought are associated with left lateral as well as bilateral frontal (and striatal) abnormalities. Impulsiveness, confabulatory verbosity, grandiosity, increased sexuality, and mania are associated with right frontal (as well as bilateral) disturbances. Gegenhalten, catatonia, and disturbances of "will" are indicative of medial frontal injuries. Disinhibitory states and obsessive-compulsive perseverative abnormalities are more frequently observed with orbital frontal lobe dysfunction, including frontal-striatal disturbances. These associations, however, are not always clear-cut as patients with the same diagnosis may demonstrate different symptoms that may be due to an additional abnormality in a different region of the brain. Moreover, as the frontal subdivisions are richly interconnected, and as frontal lobe abnormalities are not always discrete or well localized, a wide array of seemingly divergent waxing and waning symptoms may be manifest, sometimes simultaneously, including manic depression and what has been referred to as the "frontal lobe personality."
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PMID:Frontal lobe psychopathology: mania, depression, confabulation, catatonia, perseveration, obsessive compulsions, and schizophrenia. 1042 Apr 28

There is a growing interest in the distinction between grandiose and vulnerable narcissism, along with a hypothesis of a fluctuation between grandiose and vulnerable narcissism within individuals. There are several well-validated measures of both grandiose and vulnerable narcissism, but research has generally found that they are relatively distinct in their relations with their nomological networks. Further, the existing measures of narcissism do not actually assess for a possible fluctuation. The present study developed three scales of narcissistic fluctuation: fluctuation between indifference and anger, grandiosity and shame, and assertiveness and insecurity. Consistent with expectations, the FLUX scales correlated with both grandiose and vulnerable narcissism, displayed convergent and discriminant validity with factor derived-narcissism scales and the five-factor model, and correlated at moderate-to-large effect sizes with measures of affective lability. The three FLUX scales were also reduced to one unidimensional nine-item scale of narcissistic fluctuation (the g-FLUX) that retained the correlational properties for the more specific scales and had incremental validity over the Five-Factor Narcissism Inventory and Pathological Narcissism Inventory grandiose and vulnerable scales in accounting for affective lability. Results from the present study suggest that the FLUX scales may provide an informative assessment of a fluctuation between grandiose and vulnerable narcissism. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
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PMID:Assessment of fluctuation between grandiose and vulnerable narcissism: Development and initial validation of the FLUX scales. 2992 2