Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085632 (apathy)
 4,089 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirteen out of 18 young out-patients with simple schizophrenia under neuroleptic treatment completed a double-blind cross-over trial with Madopar [L-Dopa + benserazid (a peripheral decarboxylase inhibitor)] and placebo. Nine patients were given 900 mg L-Dopa + 225 mg benserazid daily, 1 patient received 600 mg L-Dopa + 150 mg benserazid, and 3 patients, 300 mg L-Dopa + 75 mg benserazid. In these doses, L-Dopa was effective against emotional withdrawal, blunted affect, tendency to isolation and apathy, without inducing or aggravating productive, accessory symptoms. The activity score, according to the specific activity-withdrawal scale, was significantly increased (P less than 0.05), whereas the total BPRS score (Brief Psychiatric Rating Scale) was slightly, but significantly reduced (P less than 0.05). In cases where L-Dopa had to be limited to 600 and 300 mg daily, a tendency to anxiety, distortion of thinking, and a sense of unreality were observed, depending on the dose of L-Dopa. In no case were gastrointestinal, cardiovascular or neurological side-effects observed.
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PMID:The effect of L-dopa on young patients with simple schizophrenia, treated with neuroleptic drugs: a double-blind cross-over trial with Madopar and placebo. 0 Jul 6

A 58-year old unemployed painter had for one year shared his apartment with his lady-friend's corpse and not talked to anyone about her death. When admitted to our hospital, loss of drive, initiative, interest, psychomotor activity and emotional response as well as poverty of speech were the main clinical features. Not having been able to care for his own vital needs such as food, shelter and protection against cold temperature, he was neglected and suffered from frost-bites. We diagnosed a schizophrenia simplex and initiated neuroleptic treatment using olanzapine. During the course of treatment there was some improvement regarding affect and psychomotor activity, his loss of drive and initiative and indifference regarding his own situation in life did hardly improve.
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PMID:[A patient who for one year shared his apartment with his dead lady-friend's corpse]. 1563 74