Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085632 (apathy)
 4,089 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a colony of severe combined immunodeficiency (SCID) mice conspicuously altered behavioural characteristics were observed: hunched position, apathy, dullness, short breath, bristled fur, emaciation, circling movements around their longitudinal axis and oblique head posture. This was most common in pregnant and lactating animals and also observed in 4 mice after experimental treatment. Pseudomonas aeruginosa, serotype P1 and Enterococcus durans, serotype D were isolated from various organs and from the middle ear. On autopsy, the mice showed signs of focal pericarditis and thickened liver capsules. The histological examination of the liver revealed mild, focal accumulations of mononuclear cells. In addition, it was observed that SCID mice with signs of this disease did not allow human peripheral blood mononuclear cells to engraft.
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PMID:Isolation of Enterococcus durans and Pseudomonas aeruginosa in a scid mouse colony. 878 69

Five days after birth of a viable Fell pony filly, yellow watery diarrhoea appeared without any signs of systemic disease. Four days later the diarrhoea ceased. On 11th day, the animal showed apathy, and a few days later, the foal was very lethargic, suffered from muscular weakness and severe watery diarrhoea that reappeared. The illness did not respond to therapy. At the age of 21 days the filly spontaneously died under symptoms of intestinal colic and pneumonia. Haematological examinations revealed lower numbers of erythrocytes as well as non-selective lymphopenia. Phagocytic activity was slightly increased, lymphocyte activity was inhibited. Histopathology showed severe alteration of the lymphatic organs. T and B lymphocytes and antigen-presenting macrophages were not arranged in characteristic areas, and the quantity of these cells was lower than would be expected. Histopathological changes in lymphatic organs resembled those described in the literature as severe combined immunodeficiency.
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PMID:Severe combined immunodeficiency in a Fell pony foal. 1646 58