Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0085631 (agitation)
 12,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This paper reports the results of epidemiological survey about liver diseases of traditional Chinese medicine (TCM). It surveyed 5606 patients at the general hospitals, and 1013 (18.07%) of them were patients with liver diseases (TCM), including 61 cases of liver Qi depression syndrome, 215 cases of liver depression and Spleen deficiency syndrome, 135 cases of liver and gallbladder damp-heat syndrome, 79 cases of liver Fire flaming syndrome, 145 cases of liver Yang rising syndrome, 209 cases of liver Wind agitation syndrome, 62 cases of liver blood deficiency syndrome, 86 cases of liver-kidney Yin deficiency syndrome and 21 cases of liver cold syndrome. The results showed that constitution ration of liver diseases (TCM). It supplies some scientific data for the clinic and research of liver diseases (TCM).
 ...
PMID:[Epidemiological survey on liver diseases of traditional Chinese medicine]. 206 94

Tolerance and pharmacokinetics after single-dose administration of atorvastatin, an investigational inhibitor of HMG-CoA reductase, were examined in 22 healthy volunteers in a three-period, partially-blinded study. Participants received capsule and solution doses of atorvastatin (0.5 to 120 mg) and placebo at weekly intervals. Atorvastatin was well tolerated at doses as high as 80 mg. The adverse event profile was similar after administration of atorvastatin capsules and placebo. Atorvastatin solution was slightly less well tolerated. The most common side effect after administration of capsules and solution was headache, followed by sporadic reports of diarrhea, flatulence, and nausea. At the 120-mg solution dose, one participant experienced mild, transient restlessness, euphoria, and mental confusion that were considered to be dose-limiting side effects. Mean concentrations of atorvastatin, maximum concentration (Cmax), and area under the concentration-time curve from time 0 to the time of the last detectable concentration (AUCo-tldc) increased with increasing dose. Plasma elimination half-life (t1/2) ranged from 14.7 to 57.6 hours. The bioavailability of atorvastatin capsules was similar to that of solution. These results suggest that atorvastatin is well tolerated after single doses as high as 80 mg, and may require administration only once daily.
 ...
PMID:Tolerance and pharmacokinetics of single-dose atorvastatin, a potent inhibitor of HMG-CoA reductase, in healthy subjects. 887 77

Karenia mikimotoi is one of the most common red-tide dinoflagellates proliferating in the eastern North Atlantic and around Japan. Kills of marine fauna are associated with its blooms. In mixed water columns it migrates vertically, while in stratified water columns, the population remains confined within pycnocline layers. Wind events, increasing mixing and agitation initiate declines in its populations. This paper is focused on the formulation of mortality rate relative to shear rate. Autotoxicity is demonstrated by the use of a synthetic toxin. Bioconvection observed in cultures allows the establishment of a trade-off between phototropism, which leads to the local accumulation of cells, and their autotoxicity, which would prevent cell concentration. The combination of these processes allows diffusion of the toxin into the underlying water, where it subsequently degrades. Confinement of the population in the pycnocline layer results also from another trade-off between growth conditions and shear-rate-modulated mortality. A simplified encounter kernel was introduced into the population dynamics equation to account for a mortality factor. Under realistic forcing conditions with a small number of parameters, this model reproduced the confinement of the population in the pycnocline layer, the proper timing and the duration of the recurrent K. mikimotoi bloom on the Ushant front (France).
 ...
PMID:Motility and autotoxicity in Karenia mikimotoi (Dinophyceae). 1747 27