Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0085631 (
agitation
)
12,064
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The filamentous fungus
Aspergillus tubingensis
that belongs to the black
Aspergillus
section has the capacity to produce high-value metabolites, for instance, Naphtho-Gamma-Pyrones (NGPs). For these fungal secondary metabolites, numerous biological properties of industrial interest have been demonstrated, such as antimicrobial, antioxidant and anti-cancer capacities. It has been observed that these secondary metabolites production is linked with the fungal sporulation. The aim of this research was to apply environmental stresses to trigger the production of NGPs in liquid cultures with
CYB
(Czapek Dox Broth): osmotic and oxidative stresses. In addition, numerous parameters were tested during the experiments, such as pH value, incubation time, container geometry, and static and
agitation
conditions. Results demonstrate that the produced amount of NGPs can be enhanced by decreasing the water activity (a
w
) or by adding an oxidative stress factor. In conclusion, this study can contribute to our knowledge regarding
A. tubingensis
to present an effective method to increase NGPs's production, which may support the development of current industrial processes.
...
PMID:Influence of the culture conditions on the production of NGPs by
Aspergillus tubingensis
. 3121 91
