Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0085593 (
chills
)
4,268
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
For insects, chilling injuries that occur in the absence of freezing are often related to a systemic loss of ion and water balance that leads to extracellular hyperkalemia, cell depolarization and the triggering of apoptotic signalling cascades. The ability of insect ionoregulatory organs (e.g. the Malpighian tubules) to maintain ion balance in the cold has been linked to improved
chill
tolerance, and many neuroendocrine factors are known to influence ion transport rates of these organs. Injection of micromolar doses of
CAPA
(an insect neuropeptide) have been previously demonstrated to improve
Drosophila
cold tolerance, but the mechanisms through which it impacts
chill
tolerance are unclear, and low doses of
CAPA
have been previously demonstrated to cause anti-diuresis in insects, including dipterans. Here, we provide evidence that low (femtomolar) and high (micromolar) doses of
CAPA
impair and improve
chill
tolerance, respectively, via two different effects on Malpighian tubule ion and water transport. While low doses of
CAPA
are anti-diuretic, reduce tubule K
+
clearance rates and reduce
chill
tolerance, high doses facilitate K
+
clearance from the haemolymph and increase
chill
tolerance. By quantifying
CAPA
peptide levels in the central nervous system, we estimated the maximum achievable hormonal titres of
CAPA
and found further evidence that
CAPA
may function as an anti-diuretic hormone in
Drosophila melanogaster
We provide the first evidence of a neuropeptide that can negatively affect cold tolerance in an insect and further evidence of
CAPA
functioning as an anti-diuretic peptide in this ubiquitous insect model.
...
PMID:Anti-diuretic activity of a CAPA neuropeptide can compromise
Drosophila
chill tolerance. 3010 6
