Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085593 (chills)
 4,268 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A diamond polisher presented with a history of dyspnea, chest tightness, chills and weight loss related to exposure to diamond cobalt disks at work. Pulmonary function showed slightly reduced lung volumes, low normal diffusing capacity and a moderate bronchial hyperresponsiveness to histamine. Chest X-ray and cell count in bronchoalveolar lavage fluid were normal. After 3 months of non-exposure, a bronchial cobalt challenge test caused an immediate decrease in specific airway conductance and in vital capacity (VC) but not in FEV1/VC. After 6 h, chills, fever, tachycardia and crackles appeared along with moderate reductions in lung volumes. After 24 h, the bronchoalveolar lavage fluid showed 43% granulocytes, and there was a marked increase in bronchial hyperresponsiveness to histamine. These changes are interpreted as combined asthma and alveolitis induced by cobalt.
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PMID:Combined asthma and alveolitis induced by cobalt in a diamond polisher. 381 65

The objectives of the study were to determine whether grinders and brazers of hard metal and stellite blades have more respiratory symptoms and dermatoses than referents and to obtain information on the relation between respiratory symptoms and combined exposure to cobalt and wood dust. Two groups of workers exposed to cobalt (108 workers in the manufacture or maintenance of tools and 116 saw filers in the mechanical wood-processing industry) and two reference groups (106 rolling mill and 103 sawmill workers) were interviewed. The prevalence of ODTS-like symptoms (work-related cough, dyspnoea, or fever or chills) was higher for the saw filers than the sawmill referents. After adjustment for age, time spent in present work, smoking and atopy, saw filers had a higher risk for fever or chills than the other study groups. When the cobalt-exposed and unexposed workers were compared by smoking, differences in the prevalence of ODTS-like symptoms were found only for the non-smokers. The cobalt-exposed workers did not have a higher risk of hand dermatoses or symptoms of metal allergy than the unexposed workers. It seems that combined cobalt and wood dust exposure is associated with ODTS-like symptoms, especially among non-smoking workers.
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PMID:Respiratory symptoms and dermatoses among grinders and brazers of hard metal and stellite blades. 913 16