Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085593 (chills)
 4,268 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Urinary tract infections (UTI's) are common in medicine. Symptoms may include fever, chills, frequency, and dysuria. Asymptomatic UTI's are also common, with a prevalence of one percent in school girls and ten percent in pregnant women. Pyuria, dysuria, and frequency may be absent in patients with UTI's or present in patients without UTI's. Therefore, a UTI must be bacteriologically diagnosed as greater than 100,000 organisms/ml, usually of a single organism, in a properly obtained urine specimen. The dipslide is a simple, convenient, inexpensive device for the quantitative diagnosis of a UTI. Culture media are layered on both sides of the dipslide, one medium allowing growth of all organisms and the other medium favoring growth of enterobacteriae. After immersion in a clean catch urine specimen, the dipslide is incubated for 24 hours at 37 C. Each urinary organism forms a colony "dot". The density of colony "dots" can be quantitated easily by comparison with standardized graphs. The dipslide is a highly accurate and sensitive tool that can be used for the diagnosis of UTI's, assessment of antimicrobial effectiveness, follow-up for presence of recurrence or relapse, and screening of high-risk individuals.
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PMID:The dipslide in diagnosis of urinary tract infections. 79 35

A new member of injectable cephem antibiotics, cefuzonam (L-105, CZON) was administered in the treatment of 11 chronic complicated urinary tract infections (CC-UTI) which were considered to be for indications of long-term chemotherapy. The results obtained are summarized as follows. Responses in 6 cases out of 9, 66.7%, were evaluated as excellent or moderate by the criteria of the Japan UTI committee at fifth day's judgement. At the end of the treatment, however, only 3 out of 8, 37.5% were determined to be effective. The apparent decrease in the efficacy of the drug after the longer treatment period was caused by replacements of susceptible bacteria with resistant strains. Side reactions were observed in 2 cases, one was diarrhea and the other was chill and fever. In these cases, the administration of the drug was discontinued, and the conditions returned to normal within a few days. In laboratory tests, a slight decrease of thrombocyte was observed in 1 case. The CZON was very effective against infections caused by susceptible bacteria. No differences between CZON and other related compounds were found with regard to safety, hence it was estimated that the drug was highly useful for a long-term treatment on infections caused by susceptible strains to CZON.
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PMID:[A study on the clinical efficacy and safety of cefuzonam with long-term administration in chronic complicated urinary tract infections]. 380 50

You start another busy shift with a double row of charts waiting to be seen. Your first patient is an elderly man who fell 1 hour prior to presentation. He did not lose consciousness, but he was dazed for a few minutes. He complains of a mild headache but denies any neck pain. He takes warfarin for valvular heart disease. He looks good and has no focal neurological complaints. His mental status is normal, he has a negative head CT scan, and his INR is 3.9. His family wants to take him home, which would help relieve some of the congestion in the ED, but you wonder what would be best. To observe and repeat imaging? Reverse his anticoagulation? Change his dosing regimen of warfarin? In the next room, you quickly evaluate a 51-year-old obese woman with nonspecific back and abdominal pain that started 24 hours before and has slowly progressed to become intolerable. She denies fever, chills, nausea, or vomiting. She is on the last day of a 5-day course of ciprofloxacin for a UTI. She takes warfarin for a pulmonary embolus that occurred 2 months prior. Her hematocrit is mildly decreased, and her white blood count is normal; however, the INR is 6.8. You wonder if her abdominal pain is related to the UTI, or if it could be somehow related to the prolonged INR. In fact, you wonder why her INR is so prolonged...
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PMID:An evidence-based approach to managing the anticoagulated patient in the emergency department. 2216 1