Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085593 (chills)
 4,268 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A clinic-based case-control study was conducted at two malaria clinics in western Thailand in order to investigate social and behavioral factors believed to be associated with malaria occurrence. The finding was that the malaria cases were predominantly male, under age 25 and single. The results showed a significant association for use of mosquito nets, conformance with DDT spraying and residing in forested areas two weeks before occurrence of illness with malaria. Analysis of symptoms revealed fever, headache and chills to be the major noticeable symptoms initiating treatment. Three basic treatment-seeking patterns were observed. The results of this study suggest that particular attention should be given to malaria health education for younger age groups and forest-related people. In addition, attention should also be given to ways of increasing awareness of symptoms, and motivation of people to use malaria clinics for malaria screening and treatment at onset of first symptoms in order to eliminate treatment-seeking at ineffective first sources. Malaria Voluntary Collaborators, Village Health Volunteers and Village Health Communicators have an important role in convincing people in malarious areas to use malaria clinics for malaria screening and treatment when the villagers develop malaria-like symptoms. This would reduce disease transmission and severity by reducing the delay for efficacious treatment and would also reduce the cost of malaria treatment.
Southeast Asian J Trop Med Public Health 1986 Sep
PMID:Health behavior, treatment-seeking patterns, and cost of treatment for patients visiting malaria clinics in western Thailand. 356 5

Amebic hepatic abscess can mimic other hepatic disorders and is a commonly missed diagnosis. It occurs when Entamoeba histolytica infection of the cecum remains untreated and there is embolic spread to the liver. Symptoms include acute or insidious onset of fever, with or without chills, pain in the right hypochondrium or epigastrium with evidence of hepatomegaly, and intercostal or subcostal tenderness. Diagnosis is established by a combination of radiologic and nuclear scanning procedures, serologic tests and aspiration of the abscess.
Am Fam Physician 1987 Sep
PMID:Amebic hepatic abscess. 363 Aug 82

We reviewed our experience with 95 patients who carried the diagnosis of brown recluse spider bite between 1983 and 1986 and identified a reference group of 17 with confirmed bites. Eight men and seven women, average age 32 years, presented within 33 hours following the bites. The most common symptoms were pain, pruritus, malaise, chills, sweats, and rash. Patients were randomized into three treatment groups: dapsone, brown recluse spider antivenom, or combination therapy. All patients were treated with erythromycin. If two patients with very severe lesions were excluded, patients in all groups healed their wounds in an average of 20 days. A comparison of our treatment was attempted with all other bites previously confirmed in the literature, but historical data were incomplete and no conclusions could be drawn.
Ann Emerg Med 1987 Sep
PMID:The diagnosis and treatment of brown recluse spider bites. 363 81

Severe adverse reactions to intravenous immune serum globulin occurred repeatedly in four of 10 hypogammaglobulinemic patients. Treatment-limiting symptoms included fever, chills, headache, hypertension, and chest pain. Pretreatment of patients with hydrocortisone immediately prior to infusion prevented subsequent adverse reactions and permitted these patients to receive immune serum globulin intravenously.
Am J Med 1986 Sep
PMID:Corticosteroids for prevention of adverse reactions to intravenous immune serum globulin infusions in hypogammaglobulinemic patients. 375 45

Bilateral pulmonary infiltrates developed in a 77-year-old woman. These were associated with chills, fatigue, a high spiking temperature, leukocytosis, and eosinophilia. Clinical symptoms abated after 24 hours, and radiologic abnormalities cleared several days after discontinuing Nalfon, plus administering prednisone. The most likely cause of these pulmonary infiltrates was a hypersensitivity or idiosyncratic reaction to Nalfon.
Ann Allergy 1986 Sep
PMID:Pulmonary hypersensitivity to nalfon. 375 22

Methylene chloride is a chlorinated hydrocarbon used widely in home and industry. Its intentional abuse has not been reported previously. We describe the case of a 14-year-old boy who presented with lethargy, nausea, and chills six hours after the intentional inhalation of a household product containing methylene chloride. The patient's elevated carboxyhemoglobin level responded well to 100% oxygen therapy. The pathophysiology and treatment of methylene chloride are discussed.
Ann Emerg Med 1985 Sep
PMID:Methylene chloride inhalation: an unusual form of drug abuse. 402 92

Eleven patients with advanced breast cancer and four with astrocytoma were treated with plasma perfused over columns containing staphylococcal Protein A (SPA). Doses of 5 to 20 mg of SPA were bound to collodion charcoal particles, and this treatment resulted in partial remissions in one patient with astrocytoma and in two patients with breast cancer. Remission duration was 6 wk to 6 mo. Resolution of lymphadenopathy and a decrease in carcinoembryonic antigen were noted in an additional two breast cancer patients. Systemic reactions to infused plasma consisted of fever, chills, and rigors. In brain cancer patients, increased intracranial pressure was also noted. A mitogenic substance was generated in plasma of 11 patients after it was perfused over the SPA charcoal matrix. The mitogenic material induced lymphoproliferation comparable to concanavalin A and required the presence of SPA on the collodion charcoal but was not due to leakage of SPA from the column during plasma perfusion. Of considerable significance was that only patients whose column perfused plasma contained this mitogenic activity exhibited systemic reactions, and five of these patients obtained antitumor responses. This striking correlation implies that the mitogenic factor is an active component of SPA therapy. The ability to demonstrate mitogenicity in column perfused plasma might also be useful for selecting patients amenable to SPA therapy. These findings attest to the therapeutic value of this mode of treatment and provide an initial definition of a mediator of SPA antitumor activity.
Cancer Res 1985 Sep
PMID:Staphylococcal Protein A column: correlation of mitogenicity of perfused plasma with clinical response. 402 30

Effective renal plasma flow was measured in acute spinal cord injury patients for up to 10 years after injury to determine the extent of renal deterioration in these patients and to identify the factors associated with a loss of renal function. The over-all mean decrease in effective renal plasma flow for all patients as a whole was 4.5 ml. per year. Factors associated with a statistically significant reduction in effective renal plasma flow included age, gender, renal calculi, quadriplegia, and a history of chills and fever. Other factors examined but not found to be statistically significant included years since injury, presence of severe decubiti, bladder calculi, bacteriuria and extent of injury. This study suggests that renal function usually can be preserved in spinal cord injury patients if the treatable risk factors are managed properly.
J Urol 1985 Sep
PMID:Long-term followup of renal function after spinal cord injury. 403 51

A 66-year-old man developed fever, chills, myalgias, three erythematous skin lesions, and transient left eyelid lag. Because of persistent fever, he was hospitalized 4 weeks after the onset of disease; a peripheral blood smear showed Babesia microti in 3% of his erythrocytes. Eighteen hours later, he died unexpectedly. Autopsy showed pancarditis with a diffuse lymphoplasmacytic infiltrate, and spirochetes were found in the myocardium. Antibody titers to both the Lyme disease spirochete Borrelia burgdorferi and Babesia microti were elevated. The finding of spirochetes in the myocardium and the elevated antibody titers to Borrelia burgdorferi suggest that the patient died from cardiac involvement of Lyme disease.
Ann Intern Med 1985 Sep
PMID:Fatal pancarditis in a patient with coexistent Lyme disease and babesiosis. Demonstration of spirochetes in the myocardium. 404 Jul 23

The effect of fever upon intracranial pressures was determined in the rabbit and cat. In the unanesthetized rabbit and cat, cerebrospinal fluid (CSF) pressure was measured via direct cannulation of the lateral cerebral ventricle. Intracranial pressure (ICP) was measured in the rabbit by a subarachnoid screw technique. In all cases, intravenous administration of bacterial pyrogen extracted from Salmonella abortus equi resulted in significant differences from controls in physiological variables measured during the initial "chill" phase of the fever. There was an increase in body temperature, a fall in CSF or ICP pulse rate, an increase in pulse pressure amplitude, and a small increase in mean CSF or ICP. In addition, venous and arterial blood pressures increased significantly and, consistent with heat conservation, there was a fall in respiratory rate as well as cutaneous vasoconstriction in the ears. The arterial carbon dioxide tension was unchanged during the prodrome but fell significantly during the chill and flush phases and rose again during defervescence. The results suggest that in these animals there is a slight increase in pressures within the cranium during the "chill" phase of a pyrogen induced fever, resulting from changes occurring in many body systems during this phase of the fever.
Brain Res Bull 1985 Sep
PMID:Fever and intracranial pressures. 405 27


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