Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085593 (chills)
 4,268 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prostaglandin (PG) E2 suppositories have been shown to be effective in uterine evacuation for mid-trimester abortion. At the University of Mississippi Medical Center, vaginal PGE2 suppositories have been used routinely to effect termination of pregnancies following fetal death at any age and in the majority of therapeutic abortions performed at over 14 weeks' gestation. This study evaluated the results of PGE2 treatment in 85 patients seen at the center during an 18-month period, the majority (65%) of whom were delivered because of fetal death. Prior to the procedure, 55% of these patients had a closed cervix and laminarias were inserted. The average time from induction with PGE2 to expulsion of the fetus was 9.3 hours (range, 1.4-23.2 hours), with no significant difference between the groups with and without laminaria unless the cervix was dilated more than 2 cm at the time of admission. 94% of study subjects required 3 or fewer suppositories to effect delivery. Of the 85 patients, 78 (91%) aborted successfully within 24 hours. There were no major complications; the incidence of minor side effects ranged from 12% (for diarrhea) to 21% (for hyperpyrexia). Overall, these findings suggest that medical induction using prostaglandins is a safe, convenient method of evacuating the uterus, particularly in the case of fetal death after 20 weeks. The minor side effects such as nausea and vomiting, fever, diarrhea, headache, and chills can be reduced when patients are premedicated with anti-emetics and antidiarrheal preparations. Moreover, these side effects may be further decreased by the use of newer compounds, such as the 15-methylated prostaglandins, that are believed to induce less reaction in the gastrointestinal tract.
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PMID:Prostaglandin E2 induction of abortion and fetal demise. 256 5