Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085593 (chills)
 4,268 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prostaglandins have found clinical applications in: 1) termination of midtrimester pregnancy; 2) induction of labor; 3) menstrual regulation; and 4) control of postpartum hemorrhage. In abortion, prostaglandins (PGs) are used to bring about rapid dilatation of the cervix and diminished flow of the utero-placental blood. They are administered via intravenous, intra- and extra-amniotic, vaginal, and intramuscular routes, and are considered to be the most efficient and safest abortifacient known. Common side effects (nausea, diarrhea, phlebitis, fever, chills and rigors, hypotension, chest pains) can be controlled by simultaneous use of drugs such as Diazapan, Squil, Stemetil, Eskazil, and Lomotil. In cases of induction of labor (e.g., intrauterine fetal death or missed abortion), PGs have a success rate of 85-98%, with minor side effects. Although PGs are used to regulate menstruation, accompanying side effects make their use for this purpose almost unacceptable. In addition, their role in controlling postpartum hemorrhage has been found to be insignificant. A clinical trial of 341 healthy pregnant women who had abortion using PGs is briefly described.
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PMID:Clinical uses of prostaglandins in human reproduction. 30 21