Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085593 (chills)
 4,268 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hypersensitivity pneumonitis (HP) appears to be an underdiagnosed condition. It may masquerade as recurrent pneumonia, idiopathic pulmonary fibrosis, Haman-Rich disease, or interstitial pneumonitis. The nature of the disease depends on the immunologic reactivity of the host and the intensity and chronicity of exposure. Causative agents include thermophilic organisms, mold, animals, and chemicals. Typical symptoms of cough, shortness of breath, chills, and fever typically begin four to six hours after exposure with a remittance on avoidance. Chest x-ray demonstrates interstitial pneumonitis, and pulmonary function testing shows a restrictive component. A precipitating IgG antibody is the immunologic hallmark. The immunopathogenesis appears to represent a combination of type III and IV immune responses. Identifying the offending antigen is vital so that appropriate environmental precautions can be carried out.
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PMID:What the allergist should know about hypersensitivity pneumonitis. 1739 Jul 53

Recurrent pneumonia with cavitation leading to pneumatoceles, secondary fungal infections, and hemoptysis are major causes of mortality and morbidity in patients with hyper-IgE syndrome. Prevention and aggressive treatment of pneumonia in these patients are essential to prevent further lung damage, but treatment may be delayed because the classic signs/symptoms of infection such as fever, chills, or rigors may be lacking. Early imaging to identify infection is essential for diagnosis and treatment. The mainstay of therapy is continuous, full-dose daily trimethoprim-sulfamethoxazole and commonly fungal coverage. Because hyper-IgE syndrome is a progressive disease, patients' condition may worsen despite compliance with prophylactic therapy.
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PMID:Hemoptysis in a Patient with Elevated Immunoglobulin E. 2769 26