Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0085584 (
encephalopathy
)
18,178
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aluminum accumulates on DNA containing nuclear structures in several human degenerative brain diseases and following the direct injection of aluminum into the brain of certain experimental animals. The enzyme
poly(ADP-ribose) synthetase
is activated following DNA damage. Aluminum added to nuclei, in vitro, at concentrations approaching that necessary to induce a progressive
encephalopathy
in animals, reduces poly(ADP-ribose) formation to 75% of control. Nuclei extracted at various stages of the aluminum
encephalopathy
exhibit a reduction in ADP-ribosylation to 50% of control nuclei. Altered ADP-ribosylation may be an important nuclear consequence of aluminum toxicity in both the experimental models and in degenerative human brain disease.
...
PMID:Aluminum inhibition of ADP-ribosylation in vivo and in vitro. 642 19
