Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085584 (encephalopathy)
 18,178 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty newborn pigs within 3 days of life were randomly divided into different groups according to the time of hypoxic-ischemic encephalopathy. The results showed that the brain damage and pathologic changes were most obvious in the 60 min hypoxia-ischemic group. Brain edema was observed in every group, especially in the group where hypoxia-ischemic lasted for more than 30 min. Cerebromalacia and hemorrhage in ventricles of brain and in arachnoid were observed, and these were particularly noticed in the group where hypoxia-ischemia lasted for 60 min.
Hua Xi Yi Ke Da Xue Xue Bao 1995 Sep
PMID:[Observation on the animal model of hypoxic-ischemic encephalopathy and the change of pathology in newborn pigs]. 858 4

In order to probe into dexamethasone's effect on glutamate receptor (Glu R) in hypoxic-ischemic encephalopathy (HIE) of newborn, we established newborn pigs' model of HIE to investigate Glu R in their forebrain crude synaptic membrane and the effect of dexamethasone in different HIE times and different dosages on the changes of Glu R. This study included five groups: HIE group (no medication); dexamethasone treatment group (10 mg/kg before HIE); dexamethasone treatment group (10 mg/kg after HIE); dexamethasone treatment group (5 mg/kg before HIE); dexamethasone treatment group (5 mg/kg after HIE). The results showed that the mean receptor density (Bmax) of dexamethasone treatment group (10 mg/kg before HIE) was significantly lower than that of the other groups (P < 0.05), but there was no statistic difference in the affinity of Glu R between all the experimental groups. These findings suggested that the preventive use of dexamethasone in large dosage would reduce the binding of Glu, and could possibly protect the brain tissues from damage in HIE.
Hua Xi Yi Ke Da Xue Xue Bao 1996 Jun
PMID:[Dexamethasone's effect on glutamate receptor in experimental hypoxic-ischemic cerebral injury]. 938 28

An animal model of hypoxic-ischemic encephalopathy (HIE) in newborn pigs was set up to study the histopathological changes of brain injury by light- and electron-microscopy, the changes in total calcium content and calcium iron of RBC, and the effects of two different doses of Nimodipine on HIE. Sixty-one newborn pigs were randomly divided into seven groups, the normal control group (n = 9); the HIE 1-hour group (n = 8) and 24-hour group (n = 8); HIE+ Nimodipine (1 microgram/kg.min-1) 1-hour group (n = 8) and 24-hour group (n = 8). The results showed that these were apparent brain edema, hematencephalon, neuron necrosis, and intracellular body degeneration in the HIE 1-hour group. The levels of RBC TCa and RBC Cai2+ in the HIE 1-hour group were significantly higher than those in the normal control group (P < 0.01). The brain tissues in all groups treated with Nimodipine showed histopathological betterment Compared with the HIE groups. The levels of RBC TCa and RBC Cai2+ in the Nimodipine treatment groups were significantly lower than those in HIE groups (P < 0.01) and were close to the levels in the normal control group (P < 0.05). The authors suggested that early application of Nimodipine in case of postnatal asphyxia might protect the newborn from severe hypoxicischemic brain lesions.
Hua Xi Yi Ke Da Xue Xue Bao 1996 Sep
PMID:[The treated effects of nimodipine on calcium of erythrocyte in experimental hypoxic-ischemic encephalopathy]. 938 66

To study the kidney lesions complicated by hypoxic ischemic encephalopathy (HIE) in newborn, we successfully established a neonatal pig model of HIE. Changes in brain tissue similar to those of newborn in HIE were detected after 2 hours of hypoxia and ischemia. Meanwhile, swelling of kidneys, hemorrhage below encapsules, swellin of tubular epithelial cells, necrosing and falling of a few tubular epithelial cells, and narrowing of tubular lumens were observed. The basement membranes of renal tubules remained normal serum BUN and creatinine increased significantly after experiment compared with before (P < 0.025 and P < 0.05 respectively). The results showed that the kidney of neonatal pig was damaged in HIE. But the injury was not severe. After 72 hours free from hypoxia, the structure and function recovered approximately from the injury.
Hua Xi Yi Ke Da Xue Xue Bao 1997 Jun
PMID:[Kidney lesions complicated by hypoxic ischemic encephalopathy of neonatal pig]. 1068 35

This experiment was designed to explore the pathogenesis in hypoxic-ischemic encephalopathy (HIE). Sixteen newborn pigs were divided into two groups: (Group A) normal control and (Group B) HIE 24 hours. The glutamate receptor (Glu R) in forebrain crude synaptic membrane (SPM) and free Ca2+i in RBC were tested respectively. The results revealed that the binding sites (Bmax) of Glu R in Group B was much lower than that in Group A, but the affinity (Kd) showed no statistic difference between Group A and Group B. In addition, free Ca2+i of RBC in Group B was much higher than that in Group A. This study demonstrates that the changes of Glu R and Ca2+i are involved in the pathogenesis of hypoxic-ischemic cerebral injury in newborn animals.
Hua Xi Yi Ke Da Xue Xue Bao 1997 Dec
PMID:[The changes of glutamate receptor and free Ca2+i in hypoxic-ischemic cerebral injury: experimental study]. 1068 54

This study was designed to explore the change of cerebral blood flow during hypoxic-ischemic encephalopathy (HIE). Sixteen newborn pigs were devided into four groups: the normal control, 15 minutes after HIE, 30 minutes after HIE and 60 minutes after HIE. The shapes of the cerebral blood vessels were obsessed by the prepared Chinese ink irrigation and the width and volume fraction of capillary were tested and analyzed by stereographic method respectively. The results showed the small blood vessels were interrupted with the passage of time. At the time of 60 minutes after HIE, capilaries almost disappeared from view, only a few ends of blood vessels in the sheap of a broken tree were seen. The width of capillaries and small veins became more and more narrow as time went on. The percentages of capillary volume fraction and small vein volume fraction became smaller and smaller (P < 0.05). These demonstrate that the fall of cerebral blood flow plays an important role in the development of HIE.
Hua Xi Yi Ke Da Xue Xue Bao 1998 Mar
PMID:[Changes of cerebral blood flow during hypoxicischemic encephalopathy in newborn pigs]. 1068 79