Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0085580 (essential hypertension)
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Human Gene/Protein
cholesteryl ester transfer protein, plasma 11.1
lethal giant larvae homolog 2 (Drosophila) 11.1
adrenergic, beta-3-, receptor 11.1
EHT 11.1
hypertension associated protein 11.1
C5orf23 10.1
Kelch-like protein 3 10.1
C4orf22 10.1
CD164L2 10.1
transmembrane protein 183A 10.1
chloride channel Kb 9.8
FAM78B 9.5
Amyloid protein A 9.5
KIAA0789 9.5
alpha-adducin 9.2
RENBP 9.1
VAV3 protein 9.1
OE-3 9.1
ADD2 9.0
G-protein beta-3 subunit 8.8
dermcidin isoform 2 8.8
PRKWNK4 8.8
Sodium/hydrogen exchanger 8.8
GNB3 8.5
SCNN1D 8.5
GOSR1 8.5
LRRC10 8.5
ATP1A1 protein 8.5
ARHGAP28 8.5
CaM-KIIN 8.3
adducin 1 8.3
NHA2 8.3
RENIN 8.2
TRIC-A 8.2
NHSL1 8.1
SLC24A3 8.1
Kv6.3 8.1
NOX5 protein 8.1
NAIP protein 8.1
STK39 8.0
more...
Disease
Compensated cirrhosis 11.1
Peripheral and visceral atherosclerosis 11.1
Labile essential hypertension 11.1
Carotid arteriosclerosis 11.1
Hypertensive renal failure 11.1
Transient hypertension of pregnancy 11.1
essential hypertension 11.1
NIDDM4 10.1
Renal parenchymal disease 10.1
NIDDM3 10.1
adrenal hypertension 9.4
high renin hypertension 9.1
secondary hypertension 9.1
borderline hypertension 8.9
Alimentary obesity 8.8
Rebound hypertension 8.5
Aase syndrome 8.5
Renal vascular disease 8.5
white coat hypertension 8.4
benign hypertension 8.3
Liddle's syndrome 8.3
Chronic lower respiratory diseases 8.3
Glucocorticoid-suppressible hyperaldosteronism 8.3
aldosteronism 8.2
genetic hypertension 8.2
Gordon's syndrome 8.1
Bilateral renal artery stenosis 8.1
uncomplicated hypertension 8.0
renal hypertension 8.0
Rheumatic valvular disease 7.9
Nephroangiosclerosis 7.9
Aortic valve prolapse 7.9
Secondary hyperaldosteronism 7.9
Hypertensive emergency 7.8
nephrosclerosis 7.7
cardiophobia 7.6
NIDDM2 7.6
metabolic syndrome X 7.6
Serum potassium increased 7.5
malignant hypertension 7.5
more...
Symptom
Epigastric discomfort 10.1
cardiovascular disability 7.3
High weight 6.8
vasovagal attacks 6.4
cardialgia 6.4
Multiple symptoms 6.3
stuffy nose 6.2
loss of taste 5.5
epigastric distress 5.5
pedal edema 5.3
lassitude 4.9
nocturnal polyuria 4.9
dizziness 4.9
exertional angina 4.7
peau d'orange 4.6
non-productive cough 4.5
bradypnea 4.4
rales 4.3
localized edema 4.3
cardiovascular impairment 4.3
asthenia 4.2
astasia 4.2
flushing 4.1
angina 3.8
No adverse effect 3.8
stomach pain 3.7
hypalgesia 3.6
alexithymia 3.5
giddiness 3.4
overweight 3.4
giddiness 3.4
muscle cramps 3.3
Stiffness 3.1
cough 3.1
lightheadedness 3.1
ketonuria 3.0
nasal congestion 2.9
headache 2.9
persistent cough 2.8
tingling 2.8
more...
Drug
Amlodipine maleate 11.1
Arotinolol hydrochloride 11.1
Indenolol hydrochloride 11.1
Delapril hydrochloride 10.1
Paraaminohippurate 10.1
Lemildipine 10.1
Mefruside 10.1
Clopamide 9.7
Tiamenidine 9.5
Tiodazosin 9.1
Tripamide 9.1
Fenquizone 9.1
Accupril 9.1
Imidapril hydrochloride 8.8
Pratosartan 8.8
Micardis 8.6
Aranidipine 8.5
Masoprocol 8.5
Guanadrel 8.5
Cilazapril 8.4
Trandate 8.4
Masoprocol 8.3
Avapro 8.3
Bendrofluazide 8.3
Selectol 8.3
Accupro 8.3
Darodipine 8.3
Cadralazine 8.2
Baypress 8.2
Indapamide 8.1
Hytrin 8.1
Estulic 8.1
Xipamide 8.0
Trandate 8.0
Aldomet 8.0
Dibenzyline 8.0
Alacepril 8.0
Isradipine 7.9
Cilnidipine 7.9
Manidipine hydrochloride 7.9
more...
Enzyme
PGE2-9-ketoreductase 7.7
renin 7.3
PRA 7.1
ACE 6.2
AGT 6.0
kallikrein 6.0
MT 1 5.9
tissue kallikrein 5.4
prostacyclin synthase 5.3
11beta-hydroxysteroid dehydrogenase 5.3
CPA2 5.2
Delta6-desaturase 5.1
aminopeptidase B 4.9
GRK5 4.9
EC 4.4.1.5 4.8
PST 4.5
20beta-hydroxysteroid dehydrogenase 4.4
CPN 4.3
oxytocinase 4.2
GTI 4.2
PHT 4.1
angiotensin-converting enzyme 2 4.1
SRR 4.0
dopamine beta-hydroxylase 4.0
aminopeptidase A 3.9
prostasin 3.9
endothelin-converting enzyme 3.8
betaine-homocysteine methyltransferase 3.8
calcium pump 3.7
dCMP deaminase 3.6
oxidosqualene cyclase 3.6
methylenetetrahydrofolate reductase 3.6
MAP 3.6
methylenetetrahydrofolate reductase 3.6
alanine aminopeptidase 3.6
thromboxane synthase 3.5
Lod 3.5
methionine synthase reductase 3.4
argininosuccinate lyase 3.4
p-nitrophenylphosphatase 3.4
more...
Compound
18-Oxocortisol 8.8
Ro 42-5892 8.8
C10H12O2 8.8
C10H12O2 8.8
Enalkiren 8.8
Guanadrel 8.5
Moexipril 8.4
Navidrex 8.4
Acebutolol 8.4
Candesartan cilexetil 8.2
Doxazosin 8.2
Chlorthalidone 8.1
Debrisoquin sulfate 8.1
Eprosartan 8.1
18-Hydroxycortisol 8.1
Canrenone 8.1
Terazosin 8.0
Minipress 8.0
Guanfacine 8.0
Etozolin 7.9
Dibenzyline 7.9
C10H14N2O 7.9
Hydrochlorothiazide 7.9
Enalapril 7.7
Bisoprolol 7.7
Tienilic acid 7.6
Metanephrine 7.6
Labetalol 7.6
Dihydralazine 7.6
Glycylproline 7.5
Quinapril 7.5
Fosinopril 7.5
Bendroflumethiazide 7.4
Perindopril 7.3
Benazepril 7.3
Nitrendipine 7.3
HC 3 7.3
Quinacrine mustard 7.3
LPR 7.2
Moxonidine 7.2
more...