Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
renin 2687
insulin 915
angiotensin II 847
Sep 816
albumin 313
ACE 278
calcium channel 276
Mol 255
Ang II 251
SBP 229
DBP 228
ATPase 212
HDL 193
angiotensinogen 184
atrial natriuretic peptide 166
kallikrein 145
Pol 137
chronic renal failure 132
angiotensin II receptor 131
bradykinin 116
urinary kallikrein 114
vasopressin 112
Mal 104
PRA 104
atrial natriuretic factor 103
EHT 99
angiotensin receptor 97
endothelin-1 97
beta 1 95
mineralocorticoid receptor 91
collagen 89
Renin 88
fibrinogen 87
AT1 83
C-reactive protein 82
nitric oxide synthase 82
sodium pump 81
parathyroid hormone 76
Angiotensin-converting enzyme 70
ACTH 67
ATP 62
natriuretic peptide 62
hemoglobin 59
aldosterone synthase 55
Cor 54
prolactin 52
GFR 49
beta-endorphin 48
leptin 47
beta-thromboglobulin 46
CYP11B2 46
ANOVA 43
endothelial nitric oxide synthase 43
MAP 42
plasminogen activator inhibitor-1 41
proximal tubule 41
AMP 40
ADP 40
thrombin 40
ANP 39
arginine vasopressin 39
vascular endothelium 37
cytokine 36
CRP 34
superoxide dismutase 34
alpha-adducin 34
adiponectin 34
sodium channel 34
ET-1 33
calcitonin 33
angiotensin I-converting enzyme 32
HSD2 31
AT1R 31
glucagon 30
MRI 30
AMN 30
Endothelin-1 29
tumor necrosis factor 28
GNB3 28
cyclooxygenase 27
interleukin-6 26
growth hormone 26
von Willebrand factor 25
She 25
HLA 25
A-I 25
TNF 25
adrenomedullin 24
NIDDM 24
CAS 24
AGT 23
adenylate cyclase 23
ENaC 23
ANG 23
calmodulin 23
kit 23
substance P 23
apolipoprotein 23
PLA 23
threonine 22
JAMA 22
neutral endopeptidase 21
Xin 21
insulin receptor 21
catalase 20
adenosine triphosphatase 20
tissue plasminogen activator 20
polypeptide 20
elastin 19
NHE1 19
angiotensin I converting enzyme 19
IL-6 19
plasminogen activator inhibitor 19
ARB 19
Polymerase 19
glucocorticoid receptor 19
apolipoprotein B 19
IgA 18
AII 18
CHD 18
neuropeptide Y 18
chromogranin A 18
adenylyl cyclase 18
apoE 17
Rho 17
ABP 17
5-hydroxytryptamine 17
thrombomodulin 17
HDL2 17
cardiac muscle 16
adrenocorticotropic hormone 16
Angiotensinogen 16
serum albumin 16
membrane-bound 16
PAH 16
reductase 16
ADD1 15
ISH 15
CYP11B1 15
UTR 15
dopamine beta-hydroxylase 15
HSD 15
CO2 15
Gen 15
tRNA 15
PTH 15
IDDM 14
endothelin receptor 14
SLC12A3 14
ANF 14
eNOS 14
erythropoietin 14
cytoskeletal protein 14
Adrenomedullin 14
BID 14
APA 13
Lp(a) 13
lipoprotein lipase 13
tissue kallikrein 13
TNF-alpha 13
more...
Disease
essential hypertension 14686
hypertension 7254
diabetes 799
ventricular hypertrophy 690
stroke 645
obesity 562
renal disease 464
aldosteronism 434
cardiovascular disease 426
atherosclerosis 412
heart failure 347
secondary hypertension 294
myocardial infarction 272
renal failure 237
congestive heart failure 236
hyperinsulinemia 224
microalbuminuria 222
type 2 diabetes 213
proteinuria 204
SEM 203
coronary heart disease 203
coronary artery disease 175
myocardial ischemia 171
renal artery stenosis 167
chronic renal failure 155
Conn 154
metabolic syndrome 153
preeclampsia 149
pheochromocytoma 141
cold 134
borderline hypertension 132
diabetic nephropathy 125
glucose intolerance 124
depression 115
psychological stress 114
hyperlipidemia 111
adenoma 108
renal hypertension 104
dyslipidemia 101
renal insufficiency 98
ischemia 88
genetic hypertension 85
vascular disease 85
systolic hypertension 84
malignant hypertension 83
ATM 83
renal impairment 82
nephrosclerosis 82
white coat hypertension 73
sympathomimetic 69
hyperuricemia 69
acute myocardial infarction 69
hypercholesterolemia 68
heart disease 65
tumor 63
cancer 60
Cushing's syndrome 53
cardiovascular risk factor 51
hyperglycemia 48
chronic glomerulonephritis 47
cardiomyopathy 46
asthma 45
hypertrophic cardiomyopathy 45
hypertensive heart disease 44
glomerulonephritis 43
pyelonephritis 42
rash 41
glomerulosclerosis 40
arteriosclerosis 40
pulmonary hypertension 40
retinopathy 39
xerostomia 35
uncomplicated hypertension 35
plaque 35
obstructive sleep apnea 34
adrenal hyperplasia 33
type 1 diabetes 33
eclampsia 31
Liddle's syndrome 30
AMN 30
Endothelial dysfunction 29
Goldblatt 29
adrenal adenoma 29
cirrhosis 28
systemic lupus erythematosus 28
sleep apnea 27
diastolic hypertension 27
peripheral vascular disease 26
dementia 26
hypoglycemia 25
cerebral infarction 25
dysplasia 25
hypertensive retinopathy 24
hypertension in pregnancy 24
emotional stress 24
hypernatremia 24
abdominal obesity 24
West 23
uremia 22
chronic renal insufficiency 20
APC 20
nephrotic syndrome 20
migraine 20
impotence 20
hypertensive nephropathy 20
rheumatoid arthritis 19
chronic obstructive pulmonary disease 18
Renovascular hypertension 18
erectile dysfunction 18
fluid overload 18
gout 18
encephalopathy 17
coronary insufficiency 17
acute renal failure 17
HDL2 17
Raynaud's phenomenon 17
cognitive impairment 17
HDL3 17
Brown 17
neurogenic hypertension 17
NAME 16
hyperthyroidism 16
chronic disease 16
primary hyperparathyroidism 16
osteoporosis 16
Alzheimer's disease 16
gestational diabetes mellitus 15
magnesium deficiency 15
pertussis 14
ISH 14
aortic stenosis 14
polycystic kidney 14
GSH 14
metabolic disorder 14
hyperhomocysteinemia 14
Bartter's syndrome 14
dilated cardiomyopathy 13
anemia 13
Syndrome 13
Proteinuria 13
hyperparathyroidism 13
pulmonary edema 13
nephritis 13
subarachnoid hemorrhage 13
acromegaly 13
SDS 12
drug withdrawal 12
toxemia 12
left ventricular failure 12
renal ischemia 12
Steroids 12
Cushing's disease 12
glomerulopathy 11
diabetic retinopathy 11
aortic regurgitation 11
liver disease 11
autonomic neuropathy 11
Posterior 11
hyperlipoproteinemia 11
psoriasis 11
more...
Symptom
headache 193
angina 137
dizziness 130
overweight 130
cough 93
fatigue 90
pain 56
flushing 52
anesthesia 34
sleepiness 28
nausea 28
diarrhea 23
asthenia 22
dystonia 21
weakness 20
chest pain 19
syncope 18
constipation 17
discomfort 16
discomfort 16
vomiting 15
spasm 13
vertigo 13
insomnia 12
dyspnea 12
Ill 10
seizures 10
exertional angina 9
exhaustion 9
abdominal pain 9
alexithymia 9
loss of taste 8
collapse 8
tremor 7
anorexia 7
hyperoxia 7
snoring 7
erythema 7
rales 6
agitation 5
myalgia 5
acute stress 5
arthralgia 5
pedal edema 4
shortness of breath 4
nasal congestion 4
lassitude 4
muscle cramps 4
polyuria 4
tingling 4
regurgitation 4
Stiffness 4
hypothermia 4
non-productive cough 3
numbness 3
back pain 3
Depressive symptoms 3
tinnitus 3
urinary frequency 3
stomach pain 3
nausea and vomiting 3
hot flushes 3
stuffy nose 3
ataxia 3
hypercapnia 3
dysarthria 3
low back pain 3
neuralgia 3
livedo 2
skin irritation 2
epigastric pain 2
cachexia 2
cardialgia 2
oliguria 2
paresis 2
No adverse effect 2
night sweats 2
spasticity 2
torticollis 2
HSA 2
ketonuria 2
nocturnal polyuria 2
bradypnea 2
acidity 2
lethargy 2
lightheadedness 2
Wind 2
analgesia 2
hemiplegia 2
persistent cough 2
wheezing 2
consciousness disturbance 2
thinning 2
hot flashes 2
polydipsia 2
myoclonus 2
leg edema 2
Sedation 1
forgetfulness 1
leg pain 1
cardiovascular impairment 1
atypical chest pain 1
abdominal discomfort 1
menopausal symptoms 1
bloating 1
Epigastric discomfort 1
chills 1
High weight 1
rigors 1
paraparesis 1
chronic back pain 1
muscle stiffness 1
general problem 1
hypalgesia 1
epigastric distress 1
giddiness 1
pallor 1
neurological disability 1
giddiness 1
chronic cough 1
paresthesia 1
clubbing 1
cyanosis 1
dental pain 1
masculinization 1
despair 1
Multiple symptoms 1
localized edema 1
Fluctuation 1
enuresis 1
hypersomnia 1
facial pain 1
vasovagal attacks 1
sore throat 1
astasia 1
stigma 1
distraction 1
hemoptysis 1
hepatomegaly 1
hypotonia 1
hypoproteinemia 1
cardiovascular disability 1
peau d'orange 1
functional recovery 1
Drug
Cardiovasc 711
Captopril 144
Nephron 94
Angiotensin II 71
Atenolol 64
Nephron 56
Clonidine 54
nitroglycerin 44
MAP 44
Hydrochlorothiazide 40
Ouabain 37
ascorbate 31
Monit 31
Valsartan 30
Isradipine 29
Ramipril 27
Indapamide 26
Felodipine 26
Dial 25
Indapamide 24
Perindopril 22
Cilazapril 22
Nebivolol 20
caffeine 18
lysine 17
PTH 16
vitamin E 15
Amiloride 13
Amiloride 13
Indomethacin 13
Olmesartan 13
ETA 12
Coral 12
Lacidipine 11
Chlorothiazide 11
ROC 11
Aliskiren 11
Cilnidipine 10
Lacidipine 10
Nadolol 10
Timolol 9
ICI 9
Methyldopa 9
Inderal 8
Diurnal 8
NADH 7
Albumin 7
Dermatol 7
Isoptin 7
NAG 7
Bosentan 6
Bosentan 6
Losartan potassium 6
Torasemide 6
Triclosan 6
Trandolapril 6
Gel 6
Cicletanine 6
CaCl2 5
CaCl2 5
Fenoldopam 5
Enalapril maleate 5
CaCl2 5
ROS 5
HCH 5
Vitamin E 5
Olmesartan medoxomil 5
Lercanidipine 5
Indoramin 5
Visken 4
Micardis 4
Timolol maleate 4
Piretanide 4
Phentolamine 4
MRC 4
Nitric Oxide 4
APM 4
Timoptol 4
citric acid 4
Dibenzyline 4
Alprenolol 4
Reserpine 4
EPA 4
MgSO4 3
DMSA 3
Guanethidine 3
TAK 3
Hypaque 3
Xipamide 3
Lofexidine 3
Bayer 3
Clopamide 3
Minipress 3
Enalaprilat 3
Omapatrilat 3
Catapres 3
Enalaprilat 3
Estrogens 3
Azelnidipine 3
IL-2 3
Sodium nitroprusside 3
Domperidone 3
Simvastatin 3
Norvasc 3
Glutathione 3
THF 3
Cadralazine 3
Ethanol 3
Trandate 3
Vitamin A 3
Digitalis 3
Estulic 3
Alacepril 3
Bendrofluazide 3
ACT 3
Tianma 3
Trimepranol 3
Aldomet 3
Nilvadipine 3
Dyazide 2
SNL 2
Cortrosyn 2
Asn 2
DHT 2
MEA 2
Baypress 2
Xanthium 2
BH4 2
Glucagon 2
Amlodipine besylate 2
Bezafibrate 2
Mutagen 2
CTA 2
Metolazone 2
Trandate 2
DDAVP 2
Lescol 2
Fragment 2
DDAVP 2
Lescol 2
niacin 2
Mefruside 2
ADM 2
Alfuzosin 2
Gastro 2
Potassium canrenoate 2
DFP 2
Ritanserin 2
Forskolin 2
Aprotinin 2
Tripamide 2
Posture 1
ABC 1
Vena 1
ENT 1
Clinoril 1
Leaf 1
Masoprocol 1
Olmesartan Medoxomil 1
Amlodipine maleate 1
more...
Enzyme
renin 2687
ACE 619
ATPase 226
kallikrein 173
PRA 104
superoxide dismutase 43
MAP 42
NO synthase 39
protein kinase C 38
thrombin 38
tissue plasminogen activator 30
tissue kallikrein 24
CD10 24
phospholipase C 24
catalase 24
AGT 23
11beta-hydroxysteroid dehydrogenase 23
adenylate cyclase 23
NADPH oxidase 22
protein kinase 21
trypsin 20
NADPH oxidase 19
mitogen-activated protein kinase 19
ERK 17
PAH 16
luciferase 16
HSD 15
GRK5 15
lipoprotein lipase 13
methylenetetrahydrofolate reductase 12
glutathione peroxidase 12
methylenetetrahydrofolate reductase 12
tyrosine hydroxylase 12
phosphodiesterase 11
alkaline phosphatase 10
aspartate aminotransferase 10
guanylate cyclase 10
dopamine beta-hydroxylase 10
monoamine oxidase 10
NOS 10
peroxidase 9
PST 9
lactate dehydrogenase 9
alanine aminotransferase 8
xanthine oxidase 8
angiotensin-converting enzyme 2 8
focal adhesion kinase 7
gamma-glutamyl transpeptidase 7
cholesterol acyltransferase 7
prostaglandin synthetase 7
phospholipase A2 7
endonuclease 7
prostacyclin synthase 7
lysozyme 6
chymase 6
CAD 6
acetylcholinesterase 6
CD13 6
CAD 6
CAD 6
APC 6
glucose-6-phosphate dehydrogenase 6
calcium pump 6
proteasome 5
thromboplastin 5
plasmin 5
creatine kinase 5
ceruloplasmin 5
PGE2-9-ketoreductase 5
glutathione S-transferase 4
alanine aminopeptidase 4
ACS 4
paraoxonase 4
beta-secretase 4
calcineurin 4
succinate dehydrogenase 4
transcriptase 4
endothelin-converting enzyme 4
reverse transcriptase 4
CPN 4
RNA polymerase 4
caspase-3 4
paraoxonase 4
aldehyde dehydrogenase 3
diamine oxidase 3
aldehyde dehydrogenase 3
p-nitrophenylphosphatase 3
thromboxane synthase 3
LPL 3
PAT 3
aldehyde dehydrogenase 3
phosphatidylinositol 3-kinase 3
collagenase 3
glutathione reductase 3
aminopeptidase B 3
aminopeptidase A 3
arginase 3
complex I 3
beta-galactosidase 3
SST 3
sulfatase 3
aldehyde dehydrogenase 3
arylsulfatase 3
elastase 3
aldehyde dehydrogenase 3
cholinesterase 3
ATP synthase 3
PHT 2
neutrophil elastase 2
alpha-amylase 2
lysyl oxidase 2
hydrogenase 2
oxytocinase 2
DNA methyltransferase 2
lipoxygenase 2
SCP 2
carboxypeptidase Y 2
argininosuccinate lyase 2
glucose oxidase 2
cytochrome oxidase 2
chitinase 2
GSK 2
xanthine dehydrogenase 2
MMP-3 2
heme oxygenase 2
carbonic anhydrase 2
MEK 2
lipase 2
12-lipoxygenase 2
furin 2
acid phosphatase 2
enolase 2
diaphorase 2
PDE 2
beta-glucuronidase 2
BMT 2
AST 2
NADH dehydrogenase 2
N-acetyltransferase 2
dipeptidyl peptidase IV 2
alpha-glucosidase 2
CYP3A4 2
phenylethanolamine N-methyltransferase 2
phosphoglucomutase 2
oxidosqualene cyclase 2
demethylase 2
hydrogenase 2
PKG 2
PPH 1
papain 1
aldose reductase 1
NPL 1
3-hydroxyacyl-CoA dehydrogenase 1
Lod 1
E-2 1
methionine synthase 1
choline kinase 1
triphosphatase 1
myosin light chain kinase 1
PDK1 1
more...
Compound
Clin 2515
sodium 2355
aldosterone 1439
calcium 1231
Dec 1188
salt 870
potassium 827
glucose 767
Cardiol 573
creatinine 545
noradrenaline 476
water 343
acetate 331
nitric oxide 296
oxygen 264
DBP 228
DBP 228
DNA 207
Insulin 189
Angiotensin II 144
arginine 142
Sodium 126
Ang II 99
Nifedipine 95
urea 92
prostacyclin 92
Salt 90
Enalapril 86
PGE2 71
Hydrochlorothiazide 70
ACTH 68
phosphate 67
sodium chloride 67
Propranolol 65
ATP 62
Propranolol 61
nitrogen 59
cGMP 56
ADP 55
mercury 52
Ketanserin 51
Adrenal 51
Losartan 50
Verapamil 50
Dopamine 46
MAP 43
Verapamil 42
Mg2+ 42
AMP 41
ADP 40
Diltiazem 40
Diltiazem 40
ADP 40
LPR 39
Doxazosin 39
Ouabain 38
Amlodipine 38
5-HT 38
homocysteine 37
Norepinephrine 37
sulfate 35
Labetalol 35
cAMP 33
EDTA 33
EDTA 33
methionine 32
Nitrendipine 32
Prazosin 31
Nicardipine 31
nitrate 30
Metoprolol 30
Carvedilol 30
hydrogen 30
CO2 30
vitamin D 29
phosphorus 29
Metoprolol 29
Telmisartan 27
Spironolactone 27
tyrosine 27
threonine 27
ethanol 27
lysine 26
leucine 26
prostaglandin F1 26
DOCA 26
Phe 25
Thiazide 25
TNF 25
zinc 25
Dial 25
Acebutolol 25
DOC 24
His 23
Uric acid 22
GMP 22
Perindopril 22
Pac 21
serine 21
Salix 20
DHA 20
Ile 19
PAC 19
Bisoprolol 19
L-DOPA 19
caffeine 18
HCl 18
DTPA 18
Guanfacine 18
alanine 18
Optimal 17
PAH 17
PGE 17
ACh 16
rubidium 16
prostaglandin E1 16
Naloxone 16
Pindolol 16
Cortisol 15
glycerol 15
Candesartan cilexetil 15
iron 14
galactose 14
Candesartan 14
copper 13
Indomethacin 13
SDS 13
GSH 13
Amiloride 13
GSH 13
Eplerenone 13
Kallikrein 13
PEP 12
glutamate 12
ETA 12
Fibrinogen 12
Diazepam 12
Gly 12
Nisoldipine 12
Chlorthalidone 11
iodine 11
hippurate 11
ICI 11
tryptophan 11
Moxonidine 11
Cholesterol 11
Terazosin 11
Quinapril 11
GTP 11
ASA 11
selenium 10
AMD 10
Hydralazine 10
A 3 10
Eprosartan 10
Timolol 9
TCM 9
TCM 9
cadmium 9
BNP 9
more...