Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A sodium-proton exchanger (NHE) is a membrane transport system taking part in intracellular sodium homeostasis. An increased NHE activity was observed in erythrocytes of primary hypertension (NTP) patients. Study group consisted of 25 NTP patients and 24 control (K). NTP patients were significantly heavier (p < 0.01) than control group (BMI 26.0 +/- 2.9 vs. 23.1 +/- 2.7, respectively). They also had significantly higher systolic, diastolic and mean arterial pressure than K (SBP 167 +/- 24.6 vs. 120 +/- 10.5; DBP 98 +/- 16.7 vs. 76 +/- 6.4; MAP 118.6 +/- 17.9 vs. 89 +/- 6.4, respectively). There was positive correlation between MAP and BMI (p < 0.02) in NTP patients. Mean NHE activity was significantly higher in NTP than in K group (9.6 +/- 3.6 vs. 8.2 +/- 2.6 mmol/L RBC/h) p = 0.05. A bimodal distribution of NHE activity in NTP group was observed. There was no correlation between NHE activity and BMI, MAP, SBP, DBP, age or positive family history of hypertension in NTP or K groups.
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PMID:[The erythrocyte sodium-proton exchanger activity in patient with primary hypertension]. 1241 5

A sodium-proton exchanger (NHE) is a membrane transport system taking part in intracellular sodium homeostasis. An increased NHE activity was observed in erythrocytes of primary hypertension (NTP) patients. The clinical use of cyclosporine A has provided new perspectives in organ transplantation and in the treatment of autoimmune diseases but is accompanied by side effects like hypertension. Study group consisted of 40 patients with end stage renal failure (ESRF) before and after renal transplantation and 48 controls. The activity of NHE was significantly higher after transplantation than before renal transplantation (p = 0.05) and than control group (p = 0.05). There was positive correlation between NHE activity and cyclosporins blood level. We excluded (in vitro and in vivo study) the influence of uremic toxins on NHE activity in patients with ESRF before renal transplantation. It gave opportunity to compare the activity of NHE before and after renal transplantation according only to aspect of immunosuppressive treatment.
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PMID:[Is hypertension after cyclosporin treatment related to sodium proton exchanger activity ?]. 1292 67