Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty four-hour blood pressure and heart rate were recorded with the Accutracker RII every hour automatically, and at the same time the urinary norepinephrine (NE) excretion rate (10.00-18.00, 18.00-22.00, 22.00-06.00, 06.00-10.00) were assessed by high performance liquid chromatography in essential hypertensive and normotensive subjects. In every time period, the absolute levels of arterial blood pressure and urinary norepinephrine excretion rate were higher in the essential hypertensive than in normotensive group. But both groups had a distinct circadian rhythm--nocturnal reductions of blood pressure, heart rate and urinary norepinephrine excretion rate. Correlation analyses confirm that arterial blood pressure was positively correlated with urinary norepinephrine excretion rate in every time period. Thus, persons with essential hypertension had similar circadian rhythm to that of normal subjects, but showed evidence of enhanced sympathetic nervous activity through out the 24-hour cycle. In addition, determination of urine NE excretion rate provides a handy and sensitive method for studying the role of peripheral sympathetic nerve in BP maintenance. As the relatively high level of NE and BP all occurred during the day time, we recommend that it could be used as an index to decide when to administer antihypertensive drugs.
Zhonghua Xin Xue Guan Bing Za Zhi 1993 Dec
PMID:[Twenty four-hour arterial blood pressure and urinary norepinephrine excretion rate in patients with essential hypertension]. 804 26

The correlation analyses were performed in 60 patients with essential hypertension (EHT) and 77 normotensives (NT) between RBC Na(+)-Li(+)-countertransport (SLC), Na(+)-K+ cotransport (SPT) and blood pressure, Quetelet index (QI), serum insulin, blood lipids, uric acid, blood glucose, etc. Results showed: (1) The SLC in EHT patients were higher, while SPT lower than NT group; (2) The difference between EHT and NT group was much prominent in SLC of male, while prominent in SPT of female; (3) There was no sex difference in SLC and SPT, and the SLC was correlated positively with QI3; (4) By multiple variants stepwise regression analysis, the SLC was shown to be associated positively with systolic and diastolic blood pressure; while the SPT inversely with systolic blood pressure. It suggests that SLC and SPT exert an independent effect on blood pressure.
Zhonghua Xin Xue Guan Bing Za Zhi 1993 Aug
PMID:[RBC Na(+)-Li+ countertransport and Na(+)-K+ cotransport in patients with essential hypertension]. 819 29

Plasma glucose and serum insulin during OGTT were measured in 33 patients with essential hypertension, 17 patients with simple obesity, 19 patients with acromegaly and 10 normal adults. Compared with control, serum insulin concentration increased in 33 patients with essential hypertension at 3 hour postload (P < 0.05) and in 17 patients with simple obesity at 1 hour postload (P < 0.05) during OGTT, 19 patients with acromegaly also had their insulin concentration increased at 1.3 hour postload (P < 0.05) during OGTT. The correlationships between diastolic blood pressure and integrated area under the curve for serum insulin concentration (r = 0.3838, P < 0.05) were observed in 33 patients with essential hypertension. Serum insulin concentration decreased in 10 patients with essential hypertension at 1 and 2 hour postload during OGTT after antihypertensive treatment with captopril or captopril plus hydrochlorothiazide. The results indicated that the patients with essential hypertension, simple obesity and acromegaly are insulin resistant and hyperinsulinemic after an oral glucose load.
Zhonghua Xin Xue Guan Bing Za Zhi 1993 Oct
PMID:[A preliminary study of insulin resistance in essential hypertension, simple obesity and acromegaly]. 820 Mar 5

Insulin resistance (IR) and intracellular calcium metabolism in 26 essential hypertensive (EH) patients (18 non-obese, 8 obese) were studied and compared with 24 normotensive (NT) subjects. The changes of plasma insulin and glucose before and after intravenous glucose tolerance test (IVGTT), the platelet cytoplasmic ionized calcium concentration ([Ca2+]i) with the fluorescent indicator Quin 2 and the Ca2+ pump activities in erythrocyte (RBC) lysates with the improved Vincenzi method were studied. These results strongly suggest that essential hypertension is characterized by fundamental metabolic abnormalities as well as hemodynamic abnormalities. Insulin resistance and abnormalities of cellular calcium metabolism, such as elevation in cytoplasmic [Ca2+], decrease in basal Ca-pump activity which rendered an increment of cytoplasmic [Ca2+], are major metabolic disturbances in patients with EH. The interaction between IR and cytoplasmic [Ca2+] is very complicated and needs further studies.
Zhonghua Xin Xue Guan Bing Za Zhi 1993 Oct
PMID:[Insulin resistance and its relationship to intracellular calcium metabolism in essential hypertension]. 820 Mar 6

The changes of erythrocyte ATPase and superoxide dismutase (SOD) activity, intraerythrocytic ionic concentration and plasma lipid peroxide (LPO) were observed in 59 patients with essential hypertension (EH). The results showed that the Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase activity and SOD were significantly lower, Ca2+ and Na+ concentration and plasma LPO were significantly higher in EH than in normals. A significant linear relationship was found between the decline of ATPase activity and changes of LPO and SOD. Both LPO and Ca(2+)-concentration were positively correlated with mean arterial blood pressure. These findings suggest that lipid peroxidation, through inhibiting ATPase activity and increasing intracellular Ca2+ concentration, plays an important role in the pathogenesis of EH.
Zhonghua Xin Xue Guan Bing Za Zhi 1993 Feb
PMID:[Clinical study on the relationship between erythrocyte ATPase activity and lipid peroxidation in essential hypertension]. 822 50

The relationship between ambulatory blood pressure (ABP) and left ventricular hypertrophy (LVH) were investigated in 137 consecutive subjects (54 healthy normotensives and 83 uncomplicated patients with essential hypertension) who underwent 24-hour noninvasive ABP monitoring and M-mode echocardiography. In the normotensive group, left ventricular mass index (LVMI) was not correlated with average daytime (6AM-10PM) or nighttime (10PM-6AM) systolic and diastolic blood pressure (SBP and DBP) except for age (r = 0.405, P < 0.01). In the hypertensive group, however, LVMIs were significantly correlated with average daytime SBP (r = 0.315, P < 0.01), nighttime SBP (r = 0.408, P < 0.01) and DBP (r = 0.304, P < 0.01). Furthermore, significant inverse correlations were found between LVMI and percentage of nocturnal reduction of daytime SBP (r = -0.393, P < 0.01) and DBP (r = -0.308, P < 0.01). The results suggest that the average levels of ABP, particularly, the level of ABP during night and the loss of circadian variation of blood pressure, would be responsible for the development of LVH. The control of blood pressure and restoration of circadian blood pressure variation might be necessary for the reversal of LVH in hypertensive patients.
Zhonghua Xin Xue Guan Bing Za Zhi 1993 Jun
PMID:[The relationship between ambulatory blood pressure and left ventricular hypertrophy in essential hypertension]. 824 24

Plasma concentrations of beta-endorphin (beta-EP), leucine enkephalin (LEK), arginine vasopressin (AVP), neurotensin (NT), renin activity (PRA) and angiotensin II (AT-II) were determined before and after the treatment with clonidine in 117 patients with essential hypertension. Before the treatment, the patient group had lower levels of beta-EP and LEK (P < 0.001), higher levels of AVP, PRA and AT-II (P < 0.05-0.01), as compared with those in control group. After 14 days of the treatment, plasma levels of beta-EP, LEK increased significantly (P < 0.001), and correlated negatively with the decrease of the mean artery pressure (r = -0.369 and r = -0.441, respectively, P < 0.01). PRA and AT-II decreased significantly (P < 0.05, P < 0.01). Decrease of AVP level was also observed, but did not reach the statistical significance. NT did not change both before and after the treatment. These data suggest that beta-EP and LEK may be involved in pathogenesis of hypertension and in hypotensive action of clonidine.
Zhonghua Xin Xue Guan Bing Za Zhi 1993 Jun
PMID:[Changes in plasma neuropeptides before and after clonidine in patients with essential hypertension]. 824 25

The changes of regulatory peptides in 100 patients with essential hypertension at different stages were studied. Four kinds of peptides in serum were measured by RIA method. The results showed that: (1) neurotensin, P-substances, beta-endorphin and leucine-enkephalin decreased significantly in the group (P < 0.01). (2) the levels of those parameters at different stages of hypertension were decreased in parallel with its severity and the difference between different stages is significant (P < 0.01). (3) norepinephrine showed negative correlation with four kinds of neuropeptides. (4) neurotensin, Beta-endorphin and leucine-enkephalin increased significantly after capton (P < 0.01). The possible mechanism and its clinical significance of the changes of those regulatory peptides in hypertension patients were discussed.
Zhonghua Xin Xue Guan Bing Za Zhi 1993 Jun
PMID:[Changes in regulatory peptides at different stages of essential hypertension and their clinical significance]. 824 26

The levels of plasma arginine-vasopressin (AVP) in 80 patients with essential hypertension were measured, and its impact on the disease and its clinical significance were studied. The results showed that: (1) The levels of plasma AVP in patients with essential hypertension were significantly higher than that in normotensive subjects (P < 0.001). It dropped to normal level after antihypertensive drugs. (2) The concentrations of plasma AVP in both hypertensive subjects and normotensive subjects were not correlated with age and sex (P < 0.05). (3) The concentration of plasma AVP in patients with essential hypertension was the highest in stage III, the lowest in stage I, and middle in stage II. (4) The levels of plasma AVP in patients with malignant hypertension were significantly higher than that in patients with benign hypertension (P < 0.05). A positive correlation was found between the levels of plasma AVP and blood pressure (r = 0.3398, P < 0.01). (5) The concentrations of plasma AVP in hypertensive subjects with ventricular hypertrophy were higher than that in hypertensive subjects with out ventricular hypertrophy (P < 0.05). (6) The concentrations of plasma AVP in hypertensive subjects with heart failure were significantly higher than that in hypertensive subjects with out heart failure (P < 0.001). The results suggest that AVP has a role in the pathogenesis of hypertension, hypertension complicated with ventricular hypertrophy and hypertension complicated with heart failure. The levels of plasma AVP may be viewed as an index of the patient's condition in hypertensive subjects.
Zhonghua Xin Xue Guan Bing Za Zhi 1993 Jun
PMID:[The changes in plasma arginine-vasopressin in patients with essential hypertension and the correlation with patient's condition]. 824 27

The fibrinolytic activity was measured in 30 patients with essential hypertension and 15 patients with acute cerebral infarction. The content of plasminogen (PLG) and plasminogen activator inhibitor-1(PAI-1) were higher in the patients with essential hypertension than in the controls. The results suggested that the fibrinolytic activity had a potential tendency towards decreasing in the patients with essential hypertension. The fibrinolytic activity was lower in the stage of cerebral attack and was higher in the stationary stage of acute cerebral infarction, which showed that a change of the fibrinolytic activity in acute cerebral infarction was related to the clinical course.
Zhonghua Xin Xue Guan Bing Za Zhi 1993 Jun
PMID:[Changes in the fibrinolytic activity in hypertension and acute cerebral infarction]. 824 28


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