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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The changes of plasma norepinephrine (NE) concentration and hemorheology in 60 patients with essential hypertension (EH) with different patterns of left ventricular hypertrophy (LVH) were observed. The results showed that a higher value in whole blood viscosity (WBV) at a shear rate of 230-s was found in concentric hypertrophy (CH) group; a significant increase in plasma NE was found in asymmetric septal hypertrophy (ASH) group. It suggests that CH appear to be a compensation adapting to the increase in afterload. Significant increase in plasma NE concentration may play an important role in the development of ASH in addition to the afterload.
Zhonghua Xin Xue Guan Bing Za Zhi 1992 Feb
PMID:[Relationship between different patterns of left ventricular hypertrophy and plasma norepinephrine and hemorheology in patients with essential hypertension]. 139 89

In the present study, the contents of plasma substance P (SP) and noradrenaline (NA) and adrenaline (AD) in human normotensive subjects and patients with essential hypertension as well as Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) were measured. The results showed that: (1) The levels of plasma SP in both hypertensive subjects were lower than that in both normotensive subjects. (2) The concentration of plasma NA and AD were significantly higher in patients with essential hypertension than that in normotensive subjects. (3) The levels of plasma SP increased and the concentrations of NA and AD decreased after antihypertensive drug treatment. These results suggest that both plasma SP and catecholamines were involved in essential hypertensive pathogenesis.
Zhonghua Xin Xue Guan Bing Za Zhi 1991 Feb
PMID:[The role of plasma substance P and catecholamines in hypertension]. 171 54

To observe the damage of vascular endothelium in vivo, we measured the circulating endothelial cell (CEC) with Hladovec's method in 30 patients with essential hypertension (EH) and 66 normal controls. The CEC was verified by direct immunofluorescent staining using anti-human factor VIII serum. The results showed that a significantly increased CEC count was found in patients with EH (3.018 +/- 1.230 vs 1.310 +/- 0.710, P less than 0.01), but the number of CEC was not parallel to the change of blood pressure quantitatively. After antihypertensive therapy, the CEC count reduced markedly in partial patients (3.371 +/- 0.770 vs 2.410 +/- 0.782, P less than 0.05). The study indicated that the damage of vascular endothelium indeed existed in EH, the abnormality can be improved by antihypertension. The CEC count was a simple and sensitive method for the demonstration of endothelial lesion in vivo.
Zhonghua Xin Xue Guan Bing Za Zhi 1991 Aug
PMID:[Changes in circulating endothelial cells in patients with essential hypertension]. 181 85

Several abnormalities of calcium transport have been reported in human essential hypertension (EHT) and spontaneous hypertensive rat (SHR). 45Ca binding capacity to erythrocyte membrane was measured in this study by filtration technique in the presence of 80 nmol/L Ca concentration. Results showed: (1) It was much lower in EHT (33 cases) than normal control (19 men) group, being 0.22 +/- 0.13 versus 0.35 +/- 0.18 nmol Ca2+/mg membrane protein (P less than 0.01), and correlated positively with blood pressure levels. (2) The average Ca binding capacity in young offsprings (15 adolescents) with both parents hypertensive was lower, but statistically not significant. (3) The average Ca binding capacity was also lower in SHR (9 rats) than control WKY (10 rats) group, being 0.83 +/- 0.27 versus 0.98 +/- 0.24 nmol Ca2+/mg membrane protein, yet statistically not significant. Therefore a decrement of membrane binding capacity might be related to the occurrence and maintenance of hypertension.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Oct
PMID:[Calcium binding capacity of erythrocyte membrane in human hypertension and spontaneous hypertensive rats]. 196 95

The Ca2(+)-ATPase activity and calmodulin (CaM) of erythrocytes and the effect of nifedipine on them were studied in subjects with essential hypertension (EHT). The results showed that both the basal and maximal Ca2(+)-ATPase activities of erythrocytes were lower in subjects with EHT than those in normal controls, and Ca2+a-ATPase activities were negatively correlated with blood pressure; the content of CaM was also reduced, and it was positively correlated with maximal Ca2(+)-ATPase activity. The basal Ca2(+)-ATPase activity was improved with nifedipine, but the maximal Ca2(+)-ATPase activity and CaM content were both unchanged significantly. Thus, the Ca2(+)-ATPase and CaM of erythrocytes might play an important role in EHT, and nifedipine has a mild effect on cellular calcium transporting.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Oct
PMID:[Changes of Ca2(+)-ATPase and calmodulin in erythrocytes and their responses to nifedipine in essential hypertension]. 215 Aug 3

The LV diastolic function of 37 cases with primary hypertension were studied by measuring the diastolic filling blood stream at mitral orifice using pulsed Doppler echocardiography. 30/37 (81%) patients were found to have impaired LV diastolic function as compared with 30 normals of a group at similar age. After 4 weeks of oral captopril treatment in 20/37 patients, BP dropped in 19/20; LV diastolic function improved in 75-80%; left ventricular mass also regressed in 16/20 captopril treated patients (210 +/- 62 vs 171 +/- 46 g, P less than 0.01). It showed that captopril is not only effective in lowering blood pressure but also in improving the impaired LV diastolic function.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Apr
PMID:[Left ventricle diastolic function in hypertensive patients and responses to captopril]. 220 6

In a randomized, blind trial, enalapril and captopril were compared in 479 patients with essential hypertension. The results showed that both enalapril and captopril had similar effects on the blood pressure. The response rate was 77.8% with enalapril and 70.4% with captopril. Blood pressure lowered 2.68/1.59 kPa (20.1/11.9 mmHg) in enalapril group versus 2.44/1.43 kPa (18.3/10.7 mmHg) in captopril group. No serious side effects were observed and both enalapril and captopril were well tolerated. Thus, enalapril and captopril appear equally effective and safe in patients with essential hypertension and enalapril is better accepted by patients because of its longer duration of antihypertensive activity.
Zhonghua Xin Xue Guan Bing Za Zhi 1990 Apr
PMID:[Effect of enalapril in patients with essential hypertension]. 220 7

15 children with and without family history of essential hypertension respectively were chosen to compare erythrocyte membrane Ca2(+)-Mg2(+)-ATPase activity measured with biochemical method. Results were as follows: erythrocyte membrane Ca2(+)-Mg2(+)-ATPase activity was lower in children with family history of essential hypertension (2.16 +/- 1.10 vs 3.36 +/- 1.19 mumol Pi.mg protein-1/hour, P less than 0.01). This may be the cause of increase of intraerythrocyte calcium in offspring of hypertensive patients.
Zhonghua Xin Xue Guan Bing Za Zhi 1989 Dec
PMID:[Comparison of erythrocyte membrane Ca2(+)-Mg2(+)-ATPase activity in children with and without a family history of essential hypertension]. 253 56

The levels of plasma kininase II (ACE), a high molecular weight-kininogen (HMW), alpha 2-mega-globular protein (alpha 2M), prekallikrein (PK), alpha 1-antitrypsin (alpha 1 AT) were determined in essential hypertension and control groups. The results showed that there is significant increase of ACE and PK activity and HMW content in patients with essential hypertension than in control group (P less than 0.001). No changes in alpha 2M and alpha 1AT were found. These results suggest that human plasma kallikrein system was inhibited in patients with essential hypertension.
Zhonghua Xin Xue Guan Bing Za Zhi 1989 Apr
PMID:[The significance of the kallikrein-kinin system in the pathogenesis of essential hypertension]. 255 23

Intracellular free calcium of platelets was studied in 45 patients with essential hypertension and in 6 patient's normotensive offspring. Intracellular free calcium of platelets in hypertensive patients was significantly higher than those in normotensive subjects (223 +/- 26 vs 170 +/- 28 nmol/lL, P less than 0.001). There was a positive correlation between intracellular free calcium of platelets and blood pressure (r = 0.653 approximately 0.729, P less than 0.001). No increase of intracellular free calcium of platelets was found in patient's normotensive offspring. 33 patients also had serum free calcium measured simultaneously. There was no difference between patients and the normotensive control (1.10 +/- 0.15 vs 1.09 +/- 0.10 mmol/L, P greater than 0.05). However, a positive correlation between serum free calcium and blood pressure (r = 0.363, P less than 0.05) and a weak positive correlation between serum free calcium and intracellular free calcium of platelets (r = 0.337, r 0.05 = 0.344) were found. These results indicated that intracellular free calcium was involved in the regulation of blood pressure, it was postulated that the intracellular free calcium of smooth muscle cell in the peripheral arteriole with resistance might have the similar changes seen in platelets. The changes of intracellular free calcium of platelets might be valuable in the prevention and treatment of hypertension and its vascular complications.
Zhonghua Xin Xue Guan Bing Za Zhi 1989 Jun
PMID:[Free calcium in platelets and the serum in essential hypertension]. 259 80


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