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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Patients with essential hypertension were given calcium channel antagonist, Nifedipine Retard or Acebutolol for 26 weeks in a single blind, randomised trial. Both drugs reduced mean systolic and diastolic blood pressure, but side effects were less frequent and caused less drop-outs in Nifedipine than in Acebutolol group of patients. We conclude that both Nifedipine Retard and Acebutolol were equally effective in essential hypertension but side effects were considerably milder in patients treated with Nifedipine Retard.
Mater Med Pol
PMID:Efficacy and tolerance of nifedipine retard vs acebutolol in patients with essential hypertension treated for 26 weeks. 263 18

The study was carried out on 23 samples of amniotic fluid taken (by amniocentesis) between 35th and 39th week from pregnant women with arterial hypertension (13 cases of hypertension induced by pregnancy, 5 cases of primary hypertension and 5 cases of hypertension accompanying renal diseases). Seven women undergoing the study gave birth to newborns with symptoms of delayed intrauterine growth below 16 centiles (group examined), 16 mothers gave birth to eutrophic babies (control group). The amniotic fluid of the two groups was studied for the following biochemical indexes: alanine and aspartate aminotransferase alkaline total and thermostabile phosphatase, ceruloplasmin, alpha-amylase, general protein, beta-lipoproteins, cholesterol, uric acid, urea and creatinine. No significant changes were found in the parameters determined between the group examined and the control group.
Ginekol Pol 1989 May
PMID:[Biochemical studies of the amniotic fluid in arterial hypertension in relation to intrauterine growth retardation. I. Parameters of the proteins, lipids, enzymes and renal maturity]. 263 82

A group of 20 patients with primary hypertension (NT) were studied for the influence of six-week propranolol therapy on the secretion of immunoreactive insulin (IR-I), gastrin glucagon (IR-G) and pancreatic polypeptide (IR-PP) induced by a high-fat test meal. The results of the examination before the therapy were compared with examination of 10 healthy persons. Before the therapy, the patients with NT revealed a decreased reactivity of IR-PP to the food stimulus. After propranolol therapy, the authors found a significant change of glucagonemia profile and pancreatic polypeptide concentration induced by a test meal. The results of the examinations made suggest a direct or indirect participation of beta-adrenergic endings in the regulation of glucagon and pancreatic polypeptide secretion in patients with primary hypertension.
Pol Arch Med Wewn 1989 Jan
PMID:[Effect of propranolol therapy on the secretion of insulin, glucagon, gastrin and pancreatic polypeptide in patients with essential hypertension]. 269 15

Authors studied effect of captopril on serum kininogen and prekallikrein concentrations, as well as on plasma renin activity (PRA) in patients with primary hypertension. The control group consisted of 18 healthy persons, 5 patients were in I, 12 in II and 8 in III WHO class. Monotherapy with 150 mg per day of captopril had been performed for 3 weeks. Patients were 3 times examined: 1--before therapy, 2--after 24 hours of treatment, 3--after 3 weeks of captopril therapy. It was proved, that captopril lowers arterial pressure with coexisting PRA increase and induces changes in kinins system such as: decrease of kininogen+ concentration and increase of serum prekallikrein level in comparison with their pretreatment values. Maximum PRA increase and blood pressure decrease were observed after 24 hours of captopril administration, whereas changes in kinins system were taking place during the whole observation period. Presented studies indicate that antihypertensive action of captopril is related to Renin-Angiotensin-Aldosterone System as well as to plasma kinins one.
Kardiol Pol 1989
PMID:[Effect of captopril on various components of the kinin system and plasma renin activity in patients with idiopathic arterial hypertension]. 269 82

In 30 patients with renovascular hypertension, 50 with hypertension in a course of arteries, 71 hypertensive subjects with coexisting parenchymal nephropathy and in 63 with primary hypertension the captopril test was performed after 8 hours night rest and within high sodium diet. Positive test result was stated in 76.67% of patients with renovascular hypertension, in 70.59% of patients with arteritis, in 53.52% of patients with hypertension and coexisting parenchymal nephropathy and in 63.49% of patients with primary hypertension. Significant correlation between increase of plasma renin activity and blood pressure decrease after captopril administration was only stated in patients with renovascular hypertension and in those with arteritis. Results of performed studies impaired the captopril test value in diagnostics of renin-dependent hypertension.
Kardiol Pol 1989
PMID:[Diagnostic value of the captopril test in patients with arterial hypertension]. 269 83

The study was carried out on 23 samples of amniotic fluid taken (by amniocentesis) between 35th and 39th week of pregnancy from 23 pregnant women with arterial hypertension (13 cases of hypertension induced by pregnancy, 5 cases of primary hypertension and 5 cases of hypertension accompanying renal diseases). Seven women undergoing the study gave birth to newborns with symptoms of delayed intrauterine growth below 10 centile (group examined), 16 mothers gave birth to eutrophic babies (control group). In the amniotic fluid of the two groups compared the authors found similar values of acid-base equilibrium and concentrations of potassium, sodium, total calcium, ionized calcium and inorganic phosphorus. Thus delayed intrauterine foetal growth is not manifested by changed values of the biochemical indicators examined in the amniotic fluid.
Ginekol Pol 1989 Mar
PMID:[Biochemical examinations of amniotic fluid in arterial hypertension and delayed intrauterine fetal growth. III. Acid-base equilibrium and ionic composition]. 280 66

The study was carried out on 23 samples of amniotic fluid taken between 35th and 39th week of pregnancy from 23 pregnant women with arterial hypertension (13 cases of hypertension induced by pregnancy, 5 cases of primary hypertension and 5 cases of hypertension accompanying renal diseases). Seven women undergoing the study gave birth to newborns with symptoms of delayed intrauterine growth below 10 centile (group examined), 16 mothers gave birth to eutrophic babies (control group). In the amniotic fluid of the group examined, bilirubin revealed a significantly higher level. The authors found no changes in the concentrations of ammonia, ions H+ and HPL between the group examined and the control group whereas they were able to observe a significantly lower level of glucose and oestrogens in the amniotic fluid in case of delayed intrauterine foetal growth.
Ginekol Pol 1989 Apr
PMID:[Biochemical examinations of amniotic fluid in arterial hypertension and delayed intrauterine fetal growth. II. Glucose, bilirubin, ammonia, hydrogen ions, estrogens and lactogenic hormone]. 280 77

The endogenous digoxin-like substance seems to play an important role in the aetiology and pathogenesis of essential and secondary hypertension. Immunoreactive digoxin-like substance was determined in 52 subjects: 17 healthy ones, 15 patients with essential hypertension, 10 cases of chronic renal failure and 10 patients with acromegaly. The substance was not found in healthy subjects, in acromegaly and essential hypertension. In chronic renal failure detectable concentrations of the substance were observed but they showed no correlation with the creatinine level and other clinical data.
Pol Arch Med Wewn 1988 Jan
PMID:[Endogenous digoxin-like substance level in essential arterial hypertension, renal failure and acromegaly]. 327 65

The study was carried out in 30 subjects with mild primary hypertension and in 82 normotensive age-matched volunteers, 18-20 years of age. Hyperoxia test was used to withdraw the tonic chemoreceptor reflex drive. The following circulatory and respiratory effects of short lasting hyperoxia were observed in the hypertensive group and in most of the normotensive subjects yet with a family background of hypertension: a decrease in the mean arterial pressure, in total peripheral vascular resistance, and in forearm vascular resistance, and a significantly greater reduction of the resting ventilation as compared to the normotensive group. Our results suggest that the augmented arterial chemoreceptor drive is one of the mechanisms responsible for the elevated arterial blood pressure and total peripheral resistance in early human hypertension. The positive response to hyperoxia test in healthy subjects with a family background of hypertension suggests a familial occurrence of the hyperactivity of the arterial chemoreceptors.
Acta Physiol Pol
PMID:Augmented chemoreceptor reflex tonic drive in early human hypertension and in normotensive subjects with family background of hypertension. 383 54

Vascularization and morphology of carotid bodies in 100 necropsies of patients with essential hypertension in comparison with the 83 normotensives were studied. The statistically significant differences between the two groups were found. The carotid bodies of hypertensive subjects were vascularized by a lower number of arteries than those of the normotensives. This difference seems to be genetically determined. The mean combinated mass of carotid bodies of hypertensive subjects was higher than this of normotensive ones. The hyperplasia of the type I cells in carotid bodies of hypertensives was found. The subjects with a lower number of glomic arteries are more susceptible to disturbation of blood flow to the carotid body, overstimulation of carotid chemoreceptors and consequent hypertension. The results of study done may support the concept of the possible role of carotid body in the pathogenesis of essential hypertension.
Acta Physiol Pol
PMID:Vascularization and morphology of carotid bodies in patients with essential hypertension. 383 57


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