Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A salt-free diet is usually useless or dangerous in the elderly subject. It has at present only rare indications, such as after acute pulmonary oedema or congestive heart failure during initial treatment. In all other cases, it may be replaced by a reasonable diet; sodium intake remains permitted, but naturally one should not fall in the opposite extreme. As in younger subjects, and provided one takes into consideration the subjacent renal condition, properly prescribed diuretics have transformed the situation in the treatment of heart failure as in essential hypertension. Naturally the patient still requires regular clinical supervision and laboratory tests which may in practice be limited to periodical estimation of blood urea and serum potassium, less regularly, blood sugar and uric acid.
Sem Hop
PMID:[Salt-free diet and diuretics in the elderly (author's transl)]. 21 98

A double-blind study of Phanurane and placebo was conducted on 61 patients with mild essential hypertension. Each patient received 2 gelules daily (2 X 50 mg of canrenone) during a 2 month period. Statistical analysis has shown that patients on Phanurane experienced a significant decrease in systolic and diastolic blood pressure compared with patients on placebo. Clinical tolerance of canrenone was excellent. Uric acid and triglyceride levels remained normal.
Sem Hop
PMID:[Effect and tolerance of Phanurane in the treatment of essential hypertension. (Double blind study) (author's transl)]. 23 24

Sotalol is a new beta-adrenoceptor blocking drug without membrane stabilizing activity, without intrinsic sympathomimetic activity and with a low cardio-depressive effect. This beta-blocking agent has an half-life much longer than the other beta-blockers (T 1/2 from 10 to 13 hours). The antihypertensive effect and tolerance of 160 mg tablets of sotalol were studied in 35 hypertensive patients aged 18 to 60 years. The drug was administred once daily in the morning. Sotalol prescribed as the only antihypertensive drug lowered the blood pressure to normal values in 21 cases with a single daily of 1 to 3 tablets. In 8 patients a partial response was obtained (25 % reduction of the initial systolic and diatolic pressure). Six patients did not respond. The clinical and biological tolerances were good; Sotalol was only discontinued in three cases. Sotalol appears to be an effective and well tolerated antihypertensive agent, specially for the treatment of moderate and recent essential hypertension in young patients.
Sem Hop
PMID:[Treatment of hypertension with Sotalol (author's transl)]. 23 80

A review of the different drugs used for the treatment of children's hypertension is done: diuretics, vasodilators and drug acting on nervous sympathetic system. The treatment of acute hypertension is described. According to personal experience based on 33 cases, a proposition of treatment of secondary chronic hypertension is presented. Then the medical cares and the follow up of the children's primary hypertension are discussed.
Sem Hop
PMID:[Medical care of children's hypertension (author's transl)]. 611 45

71 patients with essential hypertension have been followed for 7 years under effective anti-hypertensive therapy. Significant decrease in mean blood pressure was noted at the end of the first year and progressed linearly thereafter. Serum creatinine rose slightly, probably due to diuretics. Eyegrounds improved sharply during the first year, but deteriorated slightly thereafter: this may be due to increasing arteriosclerosis and validity of classification is questioned. Electrocardiogram improved during the first year, singularly in men: correlation with reduction in blood pressure was not clear. This discrepancy is discussed. It is concluded that improvement is sufficient to justify a continued treatment in this type of hypertension.
Sem Hop
PMID:[Effect of long-term therapy of essential hypertension on serum creatinine, electrocardiogram and eyeground status: a study of 71 patients over 7 years (author's transl)]. 625 92