Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study was carried out in 22 men with essential hypertension, stage I B-II B, aged 25 to 46 years, and in 10 healthy volunteers of the same age. The authors investigated indicators of systemic and intracardiac haemodynamics by echocardiography, determined the blood plasma catecholamine concentration, catecholamine excretion, renin and cyclic nucleotides activity in plasma, both at rest and during continuous submaximal graded exercise on a bicycle ergometer. The haemodynamic response to exercise differed in patients with stable HPT from healthy subjects and patients with labile HPT by an increase in diastolic blood pressure, a lesser drop in end-systolic volume and in total peripheral vascular resistance, a lesser rise in cardiac output, and by a substantially higher left ventricular mass. The left ventricular ejection fraction did not rise in patients with stable hypertension. In these patients, no statistically significant concentration of urine catecholamines and their urine excretion was observed, in contrast to the other two groups where these indicators were increased. A negative correlation was found between the left ventricular mass and the ejection fraction during exercise, which attests to a negative influence of left ventricular hypertrophy on the pump function of the heart during exercise in patients with essential hypertension.
Cor Vasa 1983
PMID:Left ventricular function, haemodynamics and certain indicators of neurohumoral control during submaximal exercise in patients with essential hypertension. 634 18

Examination of 80 patients with essential hypertension revealed a significant correlation between the tonus of peripheral muscular arterioles on the one hand, and the stage and duration of hypertension and age of the patients, on the other hand. The correlation between arteriolar tonus and indicators of cardiac pump function was less marked. The results confirmed the close relationship between changes of peripheral blood bed and development of hypertension. The use of 133Xe half-period for measuring the peripheral arteriolar tonus proved a simple, but informative method adding an important indicator of peripheral haemodynamics to the results of haemodynamic examination.
Cor Vasa 1983
PMID:[Studies on central and peripheral hemodynamics using radiocardiography and Xenon-133 muscle clearance in patients with essential hypertension]. 636 May 33

A group of 36 juvenile hypertensive patients underwent echocardiographic and electrocardiographic examinations. In 15 of them echocardiography detected increased left ventricular posterior wall and/or septal thickness in the diastole. Asymmetric septal hypertrophy with a septum posterior wall ratio greater than 1.3 was established in 7 cases (19%). The ECG abnormalities included signs of left atrial abnormality and voltage criteria after Sokolow-Lyon and McPhie. The sensitivity of electrocardiography in detecting left ventricular hypertrophy determined by echocardiography was 15% after Sokolow-Lyon, 15% after McPhie ad 31% using all the criteria combined. The specificity of ECG was 100, 87 and 87%, respectively. The ECG is less sensitive in left ventricular hypertrophy in younger individuals than in the adult population. This seems to be due to a lower degree of hypertrophy in the early stages of essential hypertension. No significant correlation of echocardiographically determined left ventricular mass with precordial ECG voltage was found.
Cor Vasa 1981
PMID:Echocardiographic and electrocardiographic findings in juvenile hypertension. 645 30

Heredity factors are of great importance in the pathogenesis of essential hypertension, but their role was until recently not reliably proved. It was only after research into histocompatibility antigens that it was possible to discover the genetic determination of a number of diseases. The purpose of the study was to reveal the genetic factors raising the risk of essential hypertension (EH). In the population of Russian nationality in Moscow, suffering from EH, HLA antigens and certain complement components were investigated. The results showed an increased frequency of HLA-A11, HLA-B13 and HLA-Bw22. However, blood C3c and C4 concentration was in the studied group of patients significantly elevated, which attests to a possible participation of the complement system in the development of EH as a factor causing vasoconstriction. The results confirm the need for further study of the immunogenetic profile of patients with EH in order to clarify certain aspects of the pathogenesis of EH.
Cor Vasa 1984
PMID:HLA antigens and the complement system in essential hypertension. 652 75

The authors compared urinary excretion of noradrenalin (NA), adrenalin (A) and dopamine (DA) in 12 patients with primary aldosteronism (PA), 54 healthy controls and 17 patients with fixed benign essential hypertension (BEH), and in PA investigated the changes occurring in the catecholamine spectrum after removal of aldosterone-producing adrenal adenoma. The patients with PA before adrenalectomy differed from the controls and patients with BEH by low NA excretion and high DA excretion. After unilateral adrenalectomy, patients with PA presented simultaneously with BP, aldosterone and renin normalization a rise in NA excretion and a drop in urinary DA to similar or lower values than those found in the controls and BEH. The results show that changes in urinary catecholamines excretion in A may be a secondary consequence of hypermineralocorticism. High DA may be the consequence of a mobilization of contra-regulatory natriuretic mechanisms in the course of aldosterone-induced sodium retention. Low NA and A may participate in lowering the plasma renin activity which in PA in suppressed, sometimes disproportionately to the actual body sodium content.
Cor Vasa 1983
PMID:Urinary excretion of catecholamines in patients with primary aldosteronism before and after unilateral adrenalectomy. 667 85

The fat cell volume from subcutaneous adipose tissue of the anterior abdominal wall has been evaluated in 10 male patients with essential hypertension and in 10 male normotensive control subjects of normal body weight as well as in 9 male obese hypertensives. In both groups with normal weight no significant differences could be confirmed whereas in hypertensives with overweight the adipose cell volume was significantly increased. Thus, no evidence of enlarged adipocytes as a primary defect in patients with high blood pressure could be obtained. The results are discussed in view of obesity, hyperlipoproteinaemia (HLP), increased lipolysis, impaired glucose tolerance, and high insulin response which frequently are associated with essential hypertension and usually favour the accumulation of triglycerides in hepatocytes and adipocytes.
Cor Vasa 1982
PMID:Adipose cell size in patients with essential hypertension. 675 84

Excretion of noradrenaline (NA), adrenaline (A), dopamine (DA) and their metabolites vanillylmandelic acid (VMA), methoxycatecholamines (MNA + MA) as well as 3-methoxy-4-hydroxy-phenylglycol (MHPG) was studied in 95 patients with essential hypertension and in 25 normal subjects on normal and low sodium diets. The patients were divided into 3 groups according to NA excretion under basal conditions. NA excretion was increased during sodium intake restriction, the highest values of this increase being found in patients whose basal NA excretion was diminished. At low sodium intake the high and the low NA excretors responded with significant increases of DA excretion. The mean excretion of VMA increased significantly on low sodium diet in all 3 groups of patients. The MNA + MA excretion decreased significantly during sodium intake restriction in patients with normal NA excretion. At low sodium intake the excretion of MHPG was highest in patients with low basal NA excretion. These data suggest that in patients with essential hypertension subjected to sodium restriction the excretion and metabolism of catecholamines are related to basal sympathetic activity.
Cor Vasa 1981
PMID:Changes in the excretion of catecholamines and their metabolites in patients with essential hypertension during sodium intake restriction. 679 Feb 25

Plasma renin activity (PRA), plasma aldosterone concentration (PAC), and urinary aldosterone (UA) were compared in 311 hospitalized patients with arterial hypertension and in 54 healthy subjects. Patients with fixed benign essential hypertension (EH) had PRA, both recumbent and upright, the same as the controls; in advanced EH, increased PRA was accompanied by higher blood pressure (BP) as well. Nevertheless no direct correlation was found between the individual values of mean BP and PRA. The group of EH with suppressed PRA (35.9%) had a higher men age and included a higher percentage of women. Suppressed PRA was proved also in 20.9% of patients with renal hypertension and in 34.4% of patients with hypertension in chronic renal insufficiency. The PAC was moderately higher in benign EH than in the controls, and so was the urinary excretion of 18-aldosterone glucuronide (UA). Markedly elevated PAC was found in groups with high PRA. In primary aldosteronism, high UA and PAC together with suppressed PRA represent an important diagnostic guideline for differentiation from other types of low-renin hypertensions. The study points out a great variance of PRA, PAC, and UA values in different types of hypertension, and analyses the significance of their changes for the pathogenesis, course, and diagnosis of arterial hypertensions.
Cor Vasa 1980
PMID:Renin-angiotensin-aldosterone system in arterial hypertension. 699 18

The effectivity of subendocardial perfusion was investigated in 266 probands aged 40-68 years (112 patients with ischaemic heart disease, 116 patients with essential hypertension, and 38 practically healthy persons) by a noninvasive technique - the myocardial vitality index (MVI) or the quotient of the diastolic and systolic tension-time indexes (DTTI/STTI). The close and statistically significant correlation was found between the MVI, findings of selective coronarography, and total physical performance (exercise tolerance threshold) in per cent of the maximal oxygen consumption (MOC) adequate to the given subject's age, sex, and body mass. Attention is drawn to the diagnostic potential of the novel mode of a rapid assessment of the expected exercise tolerance threshold in per cent of the admissible MOC, determined by the magnitude of the coronary reserved of energy output (in kcal/min or kJ/min), and to the possibilities of predicting the maximal admissible heart rate during exercise on the basis of the myocardial oxygen supply/consumption quotient during a state of relative muscular rest, reflecting the MVI.
Cor Vasa 1982
PMID:The diagnostic significance of the correlation between the effectiveness of subendocardial perfusion and the energy output compatible with the coronary reserve. 706 62

With the purpose of searching for new clinical features in labile hypertension (LH), systolic time intervals were recorded non-invasively in a group of LH patients. Obtained data were compared with a matched group of normal individuals and also with a group of young patients with chronic essential hypertension. An increase in heart rate and a reduction in carotid pulse upstroke time (Ut) in labile hypertensives differentiated this group from chronic hypertensives and normal subjects. A tendency towards a reduction in heart rate, together with an increase in Ut and ejection time during a two years follow-up study, was accompanied by stable recordings of high blood pressure values in most of the patients belonging to the LH groups. Considering LH as the initial, reversible stage of a pathologic process, changes in heart rate, Ut and ejection time, together with high blood pressure values reflect an evolution to chronicity.
Cor Vasa 1982
PMID:Diagnostic and prognostic values of systolic time intervals in labile hypertension. 706 64


<< Previous 1 2 3 4 5 6 Next >>