Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the present single blind study was the assessment of the effect of placebo on office (OBP) and 24-hour ambulatory (ABP) blood pressure in patients with mild and moderate essential hypertension (WHO stage I). Ten patients (6 males, 4 females, age 51 +/- 9 years) underwent both OBP and ABP measurements at the beginning and the end of a 2-week placebo treatment. The comparison of the results of the first (OBP 156/100 +/- 15/6 mmHg, day ABP 155/96 +/- 12/7 mmHg, night ABP 139/81 +/- 21/10 mmHg) and the second sets of measurements (OBP 152/98 +/- 22/7 mmHg, day ABP 147/90 +/- 15/7 mmHg, night ABP 134/79 +/- 18/7 mmHg) did not show a statistically significant drop in OBP and night ABP, while there was a statistically significant (p < 0.05) decrease in day ABP. Thus, the effect of placebo can influence day ABP measurements, even when OBP is not decreased by placebo administration. Possible explanations involve alerting reactions to the first ABP monitorings in selected patients with mild and even moderate hypertension.
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PMID:[Placebo effect and arterial pressure]. 805 84

Ouabainlike factors are thought to be a kind of important modulators of salt and water metabolism in essential hypertension. We purified the binding-protein of ouabain (OBP) from human plasma. The amino-terminal sequence of OBP from human plasma, (NH2-TLGQPREPQVYTLPPXREEM-), indicated that OBP is the carboxy-terminal fragment (14.4 kDa by SDS-PAGE) from T218 of IgG2 heavy chain and from A221 of the IgG1 heavy chain constant region. Moreover, plasmin-cleaved Fc fragment (pFc) of IgG possessed the ouabain-binding activity by the gel-filtration method of pFc and authentic ouabain mixture, whereas neither intact, aggregate, nor papain-cleaved Fc fragment did. The amino-terminal sequence of pFc was NH2-THTXPPXPAPELLGGPXVFL-, and this sequence corresponded to the T105 to L125 fragment of the IgG1 heavy chain constant region. The growth of cultured THP-1 cells were arrested in the dose-dependent manner by ouabain, which was inhibited by the addition of 20 microg/mL of pFc. These results suggested that plasmin-cleaved Fc of human IgG is one of the binding protein of ouabain/ouabainlike factor(s) in human plasma.
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PMID:Purification and characterization of ouabain-binding protein in human plasma. 968 24

Only a few large prospective trials intended to address the question of whether management of hypertensive patients should be guided by office (OBP) or ambulatory blood pressure (ABP) and whether fatal and nonfatal cardiovascular events are better predicted by ABP than they are by OBP are going on. Office versus Ambulatory (OvA) recording of blood pressure, a European multicenter study, is a multicenter prospective, 10 000 patient-years follow-up study of treated essential hypertension designed to correlate blood pressure to prognosis, blood pressure being defined either by ABP or OBP. Early in 1997, inclusion was stopped (n = 2224 inclusions, 48.3% women, aged 56.8 +/- 13.1 years) because the required number had been exceeded. Inclusion data reveal that OBP (152.9 +/-21.2/92.7 +/- 10.9 mmHg) of a large portion of patients remains high, although patients had been treated for at least 3 months with antihypertensive drugs. Mean 24 h ABP averaged 133.3 +/-15.9/84.0 +/-11.0 mmHg and 24 h blood pressure and heart rate profiles, large differences in drug treatment, apparatus, type of patients, and patients' activities notwithstanding, were like those expected from well-controlled studies. Risk profile was not particularly high. Evolution of OBP, ABP and electrocardiographic and echocardiographic indices of left ventricular hypertrophy indicate that reeductions of the OBP, ABP, and electrocardiographic indices of left ventricular hypertrophy had occurred after 12 months, after 24 months follow-up there was no longer any further change for most parameters. In conclusion, analysis of inclusion and preliminary follow-up data indicates that the OvA study is running well and that it is likely that final analysis of the data and events from the OvA study will lead to an answer to the study question of whether ABP monitoring is better suited than is OBP to deal with management of the treated hypertensive patient.
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PMID:Office versus Ambulatory (OvA) recording of blood pressure, a European multicenter study: inclusion and early follow-up characteristics. 1021 49