Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To investigate the relationship between nitric oxide synthase (NOS), endothelin (ET) and the initiation of hypertension and atherosclerosis, 5 hypertensive rats (systemic pressure 22.7-24 kPa), 5 atherosclerotic rats (by cholesterol-rich diet, 3 months), and 5 normal Wistar rats were used for determination of the distribution of NOS and ET of aorta by histochemical methods. The levels determined in the three groups were quantitated and compared by computer-imaging analysis. The results showed that in early stage of atherosclerotic process, the NOS decreased while the ET increased in aorta. In early stage of essential hypertension, however, both NOS and ET levels increased. These results suggest that the increased ET and the change of NOS may play a role in the pathogenesis of hypertension and atherosclerosis.
Hua Xi Yi Ke Da Xue Xue Bao 1998 Jun
PMID:[Relationship between nitric oxide synthase, endothelin and the initiation of hypertension and atherosclerosis]. 1068 6

The autopsy materials of 45 cases of primary hypertension were studied retrospectively. The arteriolar lesions were reviewed. The arterioles < 100 microns in diameter were defined as distal arterioles; those > or = 100 microns and < 300 microns in diameter were proximal arterioles. The lesions of arteriolar wall were categorized as plasma infiltration and hyaline degeneration, and according to seriousness, the latter was divided into three degrees: I, II and III. The results revealed that (1) the arteriolar lesions in different areas of the body were at different stages of seriousness; (2) the changes in the distal arterioles were earlier than those in the proximal ones; in brain, the proximal arterioles dilated first, and then occurred the hyline degeneration; (3) hyaline degeneration took place early in the abdominal organs such as kidney, liver and pancreas, but relatively late in brain; (4) different parts of an organ were at different stages of seriousness; and (5) the lesions in different organs led to different consequences. The pathogenesis of arteriolar sclerosis in primary hypertension was also discussed.
Hua Xi Yi Ke Da Xue Xue Bao 1999 Jun
PMID:[Pathological morphology of arterioles and main visceal organs in primary hypertension--an analysis of 45 autopsies]. 1221 56

This study was intended to elucidate the relationship between arteriolar pathological changes and encephalorrhagia in the cases of primary hypertension. Gross anatomy and histology of brain were observed in autopsy of 45 cases of primary hypertension. Forty cases of arteriolar hyalinization including 26 cases of brain hemorrhage were found in those 45 cases of primary hypertension. The hyalinized arterioles were divided to two types. One is characterized by the narrow lumen of terminal arterioles, the other by the dilatant lumen of proximal arterioles. Hemorrhage always occurred in the latter type. Besides these changes, 3 cases of acute necrosis and 5 cases of atherosclerosis in arterioles were related to hemorrhage. These data suggest that brain hemorrhage of primary hypertension mainly occur in dilated and hyalinized arterioles, and some cases are probably related to acute necrosis or atheroscleromatous atrerioles.
Hua Xi Yi Ke Da Xue Xue Bao 2000 Sep
PMID:[The relationship between arteriolar pathological changes and brain hemorrhage in primary hypertension cases]. 1254 41