Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Query: UMLS:C0085580 (
essential hypertension
)
14,686
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Evidence is available which suggests that the use of thiazide diuretics in the treatment of
essential hypertension
causes a fall in both plasma and total body potassium. The incidence of ventricular arrhythmias is proportional to the potassium deficit and may be enhanced by concomitant magnesium deficiency. Potassium loss may be minimized by limiting the dose of diuretic and by restricting sodium intake.
Potassium chloride
supplements are of relatively limited value and potassium-conserving diuretics are to be preferred in aviators. To reduce the potential risk of rhythm disturbance, aircrew receiving thiazide diuretics should be managed to ensure a serum potassium level at least 3.5 mmol l-1 after stabilization on therapy.
...
PMID:Diuretics, potassium depletion and the risk of arrhythmias. 637 78
