Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the present study we have investigated the association of three single nucleotide polymorphisms in glutathione peroxidase (GPx) genes GPX1 rs1050450 (P198L), GPX3 rs2070593 (G930A) and GPX4 rs713041 (T718C) with the risk of cerebral stroke (CS) in patients with essential hypertension (EH). A total of 667 unrelated EH patients of Russian origin, including 306 hypertensives (the EH-CS group) who suffered from CS and 361 people (the EH-CS group) who did not have cerebrovascular accidents, were enrolled in the study. The variant allele 718C of the GPX4 gene was found to be significantly associated with an increased risk of CS in hypertensive patients (odds ratio (OR) 1.53, 95% confidence interval (CI) 1.23-1.90, P(adj) = 0.0003). The prevalence of the 718TC and 718CC genotypes of the GPX4 gene was higher in the EH-CS group than the EH-alone group (OR = 2.12, 95%CI 1.42-3.16, P(adj) = 0.0018). The association of the variant GPX4 genotypes with the increased risk of CS in hypertensives remained statistically significant after adjusting for confounding variables such as sex, body mass index (BMI), blood pressure and antihypertensive medication use (OR = 2.18, 95%CI 1.46-3.27, P = 0.0015). Multiple logistic regression analysis did not reveal any interaction between various combinations of GPX1, GPX3 and GPX4 genotypes regarding the risk of CS in patients with EH. The study demonstrated for the first time that the C718T polymorphism in the 3'-untranslated region of the GPX4 gene could be considered as a genetic marker of susceptibility to CS in patients with EH.
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PMID:The C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension. 2215 10

Several studies have reported that insulin resistance and compensatory hyperinsulinemia often coexist with hypertension. Increased activity of glutathione peroxidase has been reported in patients with essential hypertension. Recently, overexpression of glutathione peroxidase has also been linked to the etiology of insulin resistance. The aim of this study was to determine the possible relation between the activity of glutathione peroxidase and insulin resistance status in essential hypertensive patients. A case-control study was performed on 35 hypertensive patients and 30 control subjects. The levels of insulin and insulin resistance as measured by the homeostasis model assessment insulin resistance index (HOMA-IR) and glutathione peroxidase were significantly increased in hypertensive patients compared with control subjects. In this study, a direct association was observed between glutathione peroxidase with HOMA-IR and insulin levels in essential hypertensive subjects. In conclusion, our results suggest that increased glutathione peroxidase can be one of the detrimental factors in contributing to insulin resistance in essential hypertensive subjects.
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PMID:Elevated glutathione peroxidase in newly diagnosed hypertension: its relation to insulin resistance. 2289 88


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