Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Copper IUDs, oral contraceptives, "morning-after' pills and injectables are discussed in general in this review. Small IUDs are less effective, but better tolerated. An exception is the Dalkon shield, which is no longer manufactured because several women died from latent infections when they became pregnant. The Copper T IUD is tolerated much better than the Copper 7, and has only a 3% failure rate. Copper Ts must be replaced every 2 years, however, and are difficult to remove. A beneficial effect of IUDs is cure of uterine adhesions; a subjective side effect if discomfort reported by husbands. Strict contraindications or oral contraceptives are history of cholostatic jaundice of pregnancy, thromboembolism, essential hypertension, tension, diabetes, gynecologic cancer and pregnancy. Relative contraindications are hyperthyroidism, hyperlipidemia, and depression. Depressions occuring soon after starting pills may be due to unconscious rejection; those appearing later may be due to the progestagen itself. The subjective sequelae of pills are more likely in maternal women, women raised to feel guilty for using contraception, women susceptible to believing sensational media reports about pills, and women dominated by their husband's views. Pills are beneficial for essential dysmenorrhea, menstrual irregularity, premenstrual syndrome, depression, frigidity due to fear of pregnancy, uterine hypotrophy, ovarian cyst, certain ovarian dystrophies such as Stein Levinthan syndrome, menopausal symptoms, acne and hirsutism. The morning after pill, 5 mg ethinyl estradiol for 3 consecutive days, is indicated only in exceptional cases such as rape. Injectables are more suitable for those who desire long-term contraception and whose who want no more children. A lower cancer rate has been reported for users of depot progestagens than for women notu sing contraception.
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PMID:[Subjective and objective aspects of modern methods of contraception]. 114 75

Estrogen-related cardiovascular dysfunction was noted in 23 out of 30 patients with prostatic cancer (PC). Coronary subjects with PC suffered from cardiac pain evident on ECG necessitating correction by effective doses of coronary active drugs. PC patients with essential hypertension exhibited frequent headache, progressive edema of the legs, drastic hypertensive reactions. It is held that estrogen therapy for prostatic cancer should be preceded and monitored by therapeutic evaluation responsible for optimal conditions to prevent and early diagnose cardiovascular complications.
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PMID:[Diagnosis and therapeutic correction of changes in the cardiovascular system of patients with prostatic cancer treated with estrogens]. 208 39

Noninvasive ambulatory blood pressure monitoring has shown that blood pressure exhibits a pronounced circadian variation in both normotensive volunteers and patients with essential hypertension, with a daytime peak and a nocturnal fall. To investigate the effect of oral contraceptives (OCs) on the 24-hour blood pressure profile during the follicular and luteal phases of the menstrual cycle, a case-control study was conducted involving 20 users of OCs (0.03 mg ethinyl estradiol and 0.15 mg levonorgestrel) and 20 age- and weight-matched healthy controls. Linear and rhythm analyses revealed that both systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly higher in OC users than in controls throughout the 24-hour observation period. The 24-hour, daytime, and nighttime means of SBP and DBP were not dependent on menstrual cycle phase. In both groups, peak SBP values occurred around 15-17 hours, trough values at 4-5 hours at night, and maximum slopes between 8-10 in the morning. Of the 240 individual 24-hour blood pressure profiles analyzed, only 12 (5%) did not exhibit a significant circadian rhythm. Finally, urinary aldosterone excretion was significantly higher among OC users in both phases of the menstrual cycle.
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PMID:Blood pressure rhythm and endocrine functions in normotensive women on oral contraceptives. 872 87