Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Laboratory studies have shown that angiotensin receptor blockers (ARBs) can affect extracellular matrix (ECM) metabolism and thereby have a beneficial effect on vascular remodeling. The aim of this study was to examine the clinical effects of the ARB candesartan cilexetil on serum markers of synthesis and degradation of ECM, as well as their relation to changes in arterial stiffness in hypertensive patients. Twenty-three patients with essential hypertension were recruited for this study. Markers related to ECM synthesis and degradation (procollagen type 1 propeptide [PIP], procollagen type III propeptide [PIIIP], matrix metalloproteinase-3 [MMP-3, stromelysin-1], tissue inhibitor of matrix metalloproteinases [TIMP-1], and hyaluronic acid [HA]) were examined both before and after one year of treatment with candesartan. Pulse-wave velocity [PWV] and ankle-brachial pressure index [ABI] were measured two months (i.e., after achieving blood pressure reduction) and one year after the initiation of therapy. PWV values after one year of treatment with ARB were significantly decreased compared to previous values, whereas ABI values were unchanged. Treatment with ARB was also associated with a significant decrease in serum PIIIP values and an increase in serum stromelysin-1, whereas changes in PIP, TIMP-1, and HA did not achieve statistical significance. A significant relationship was found between the changes in PWV and the changes in stromelysin-1 levels after correction for blood pressure and heart rate (p = 0.02). These results suggest that the treatment for just one year with ARB results in significant changes in markers of ECM metabolism as well as PWV. These effects on ECM metabolism could have a beneficial effect in decreasing vascular pathology in patients with essential hypertension.
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PMID:Effects of the angiotensin receptor blocker candesartan on arterial stiffness and markers of extracellular matrix metabolism in patients with essential hypertension. 1682 Mar 47

Accumulating data suggest that activity of matrix metalloproteinases (MMPs) is increased in aortic dissection, and in thoracic and abdominal aneurysms. In the present study we sought to determine circulating stromelysin (MMP-3) concentration and its relationship with hypertension-induced aortic root dilatation. The study population included 42 patients with essential hypertension. The subjects were divided into two groups according to echocardiographically measured aortic diameter as those with aortic dilatation (n = 22) and without aortic root dilatation (n = 20). Plasma concentration of MMP-3 was determined by one-step sandwich enzyme immunoassay (EIA) method and compared in both groups. Baseline demographic properties were similar in both groups. Plasma stromelysin (MMP-3) level was significantly higher in patients with aortic dilatation than those without aortic dilatation (5.2 +/- 2.3 vs 3.3 +/- 1.9 ng/ml; P = 0.007). In conclusion, we found that circulating stromelysin (MMP-3) concentration was elevated in hypertension-induced aortic root dilatation.
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PMID:Circulating stromelysin concentration is elevated in hypertensive aortic root dilatation. 1933 98