Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of a two-week high sodium diet on mitral flow pattern were assessed in 29 patients with essential hypertension (81.9 +/- 6.9 years). Transmitral flow was recorded during different rates of salt intake; 7 g/day for 8 weeks and 20 g/day for 2 weeks. With sodium loading, 25 patients whose mean blood pressure (MBP) increased by 10 percent or more were termed salt-sensitive (SS) group, and 4 patients whose MBP did not change or increased by less than 10 percent were termed non-salt-sensitive (NSS) group with mitral flow velocity integral, cardiac output (CO) and total peripheral resistance (TPR) were calculated. Thirteen of the SS patients were defined as "SST" in which an increase in TPR was greater than that in CO with sodium repletion. In the remaining 12 SS patients termed "SSc", the increase in CO was greater than that in TPR with salt loading. CO increased significantly in the SSc patients, but did not change in the SST or NSS group with sodium loading. TPR increased significantly in the SST and NSS subjects, and decreased significantly in the SSc patients. Peak velocity of transmitral flow in the rapid filling phase (R) decreased significantly in the SST and NSS patients, and increased significantly in the SSc group. On the other hand peak velocity of transmitral flow in the atrial contraction phase (A) increased significantly in the SST and SSc groups, but remained unchanged in the NSS patients. There was a significant increase in A/R in the SSt group and a significant decrease in A/R in the SSc patients with sodium loading.
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PMID:[Mitral flow responses to two-week salt loading in elderly hypertensive patients]. 189 33

Three-week effects of a high sodium diet on mitral flow pattern were assessed in 23 patients with essential hypertension (81.8 +/- 6.8 years). Transmitral flow was recorded during different rates of salt intake: 7 g/day for 8 weeks, 20 g/day for 3 weeks. With sodium loading, 19 patients whose mean blood pressure (MBP) increased by 10 percent or more were termed the salt-sensitive (SS) group, and 4 patients whose MBP did not change, or increased by less than 10 percent were termed the non salt-sensitive (NSS) group. With mitral velocity integral, cardiac output (CO) and total peripheral resistance (TPR) were calculated. Fourteen of the SS patients, in which an increase in TPR was greater than that in CO with sodium repletion, were defined as "SST". In the remaining 5 SS patients, termed "SSC", an increase in CO was greater than that in TPR with salt loading. CO increased significantly in the SSC patients, but did not change in the SST or NSS group with sodium loading. TPR increased significantly in the SST, and remained unchanged in the SSC or NSS patients. Peak velocity of transmitral flow in the rapid filling phase (R) decreased significantly in the SST patients, increased significantly in the SSC group, and remained unchanged in the NSS subjects. While, peak velocity of transmitral flow in the atrial contraction phase (A) increased significantly in the SSC group, it remained unchanged in the SST and NSS patients. There was a significant increase in A/R in the SST group and a significant decrease in A/R in the SSC patients with sodium loading.
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PMID:[Mitral flow responses to three-week salt loading in elderly hypertensives]. 206 7

Thirty-one patients with essential hypertension (81.6 +/- 6.9 years old) were studied during two different regimens of sodium intake: 120 meq/day for 8 weeks and 344 meq/day for 2 weeks. Systemic hemodynamic data were measured with Doppler echocardiography from which the mitral flow velocity integral, cardiac index, and total peripheral resistance were calculated. The salt-sensitive patients in whom the increase in total peripheral resistance was greater than the increase in cardiac index with salt loading were termed SST. In the salt-sensitive patients termed SSC, the increase in cardiac index was greater than the increase in total peripheral resistance with increased sodium intake. All SST patients on day 7 of the high sodium diet remained in the SST group on day 14. Nine of 13 patients in the SSC group on day 7 remained in the SSC group on day 14, and the remaining four patients in the SSC group on day 7 fell into the SST group on day 14. Four of eight non-salt-sensitive (NSS) patients on day 7 of the high salt regimen remained in the NSS group on day 14, whereas the remaining four patients in the NSS group on day 7 fell into the SSC group on day 14. Our data suggest a changing pattern with sodium loading of initially high cardiac index followed by a persistently raised total peripheral resistance. The celiac, superior mesenteric, and renal arteries vasoconstricted with sodium repletion in both SST and SSC patients. With salt loading, the terminal aortic vascular bed vasodilated in the SSC patients and vasoconstricted in the SST patients.
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PMID:Time course of hemodynamic responses to sodium in elderly hypertensive patients. 221 Aug 6