Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

131 patients with essential hypertension (EH) and 30 patients with secondary hypertension (SH) of renal genesis were examined, all of them Russian inhabitants of Moscow, aged 20-56. In patients with EH increased rate of HLA-B13 and B22 antigens was determined. The highest rate of HLA-B13 antigen in this group was registered in patients without IHD, while patients with IHD had the highest rate of HLA-B22 antigen compared to controls. Patients with SH demonstrated no significant difference in HLA antigens distribution from that in controls. Besides, patients with EH had significantly increased serum concentration of circulating immune complexes (CIC), of IgA and beta 2-microglobulins as well as of three complement components (C3c, C4 and B factor). Similar changes were observed in patients with SH, excluding CIC and C3c, concentration of which did not differ from that in the control group. No strict dependence between the level of immunity humoral factors and presence of HLA-B13 and -B22 antigens was observed. The data gained suggest possible association of HLA system with EH development.
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PMID:[Various immunological aspects of essential and symptomatic hypertension]. 316 69

An immunogenetic study of 71 patients with essential hypertension associated with no signs of heart or renal failure, and 276 normal Russian male residents of Moscow demonstrated a significantly increased frequency of antigens HLA-B13 (p less than 0.01) and HLA-B22 (p less than 0.05), as well as HLA-A11 (p less than 0.05), in the hypertensive sample. Aggravated heredity (familial hypertension) was established in 64% of hypertensive carriers of antigens HLA-B13 and HLA-B22.
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PMID:[Distribution of HLA antigens in patients with hypertension]. 406 58

Heredity factors are of great importance in the pathogenesis of essential hypertension, but their role was until recently not reliably proved. It was only after research into histocompatibility antigens that it was possible to discover the genetic determination of a number of diseases. The purpose of the study was to reveal the genetic factors raising the risk of essential hypertension (EH). In the population of Russian nationality in Moscow, suffering from EH, HLA antigens and certain complement components were investigated. The results showed an increased frequency of HLA-A11, HLA-B13 and HLA-Bw22. However, blood C3c and C4 concentration was in the studied group of patients significantly elevated, which attests to a possible participation of the complement system in the development of EH as a factor causing vasoconstriction. The results confirm the need for further study of the immunogenetic profile of patients with EH in order to clarify certain aspects of the pathogenesis of EH.
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PMID:HLA antigens and the complement system in essential hypertension. 652 75