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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Haemodynamic ambulatory monitoring was derived from the intra-arterial blood pressure (BP) profile in 10 patients with essential hypertension. Stroke volume (SV) was computed beat by beat according to the following formula: X x PSA x (1 + St/Dt), where X is a correction factor, PSA is the area under the systolic portion of the pressure curve, St is the systolic and Dt the diastolic time. The X value was obtained in each patient by predetermining SV by thermodilution and solving the previous formula by X. The correlation between SV calculation and SV measured independently by thermodilution was highly significant: r values ranged from 0.85 to 0.92 (intercepts close to 0 and slopes close to 1) during different situations (supine, tilt, dynamic and static exercise). In five patients continuous haemodynamic ambulatory monitoring was obtained by applying the formula above to the intra-arterial tracing recorded with the Oxford technique. A computer program was developed in order to get BP, heart rate (HR), SV, cardiac output (CO) and total peripheral resistance (TPR) simultaneously. In these patients, the morning increase of BP was determined by an increase of both CO and TPR. Stroke volume increased slightly during the night, probably as a consequence of a reduced HR.
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PMID:Continuous haemodynamic ambulatory monitoring in essential hypertension. 285 40

A method for estimating cardiac output (CO) from the intra-arterial blood pressure profile ("contour method") was tested in 8 patients: 6 with essential hypertension, 1 with a pheochromocytoma and 1 with orthostatic hypotension. CO (1/min) was derived by the following formula: PSA (1+St/Dt) X HR 10(-3), where PSA is the area under the systolic portion of the pressure curve, St is the systolic and Dt the diastolic time, X is a correction factor, HR is the heart rate and 10(-3) is a conversion factor from ml/min to 1/min. The "contour method" was compared to the thermodilution CO method. The correlation between the 2 methods was highly significant: the r value in all patients during different conditions (supine, tilt, dynamic and static exercise) ranged from 0.91 to 0.97 with an intercept close to 0 and a slope close to 1. These results indicate that CO is properly measured from the intra-arterial blood pressure profile by the "contour method". A continuous hemodynamic monitoring can be derived applying the "contour method" to the intra-arterial blood pressure profile obtained with the Oxford technique.
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PMID:Possibility of cardiac output monitoring from the intra-arterial blood pressure profile. 400 46