Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study was undertaken to examine 190 males, aged 30-60 years who were divided into 4 groups: (1) patients with essential hypertension; (2) those with postinfarction cardiosclerosis; (3) those with postinfarction cardiosclerosis and essential hypertension; (4) healthy individuals. The levels of apolipoproteins B and A1 and circulating immune complex cholesterol were examined in the cold (winter) and hot (summer) seasons in the areas of arid (Ashkhabad) and temperate (Moscow) climate. The major apo-proteins were determined by enzyme uncompetitive immunoassay. Cholesterol levels in the immune complexes were measured by the method developed at the Institute of Experimental Cardiology, All-Union Cardiology Research Center, USSR Academy of Medical Sciences. The Moscow examinees were found to have more profound changes in the lipid spectrum than the Ashkhabad ones. In both climatic zones, the level of the major apo-proteins and their ratio were unaffected by seasonal variations.
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PMID:[Comparison between seasonal changes in lipid indicators in patients with post-infarction cardiosclerosis and arterial hypertension in Ashkhabad and Moscow]. 153 90

Blood vasopressin, tri-iodothyronine, total thyroxine, thyrotrophic hormone, cortisol, ACTH and insulin levels were measured in 60 chronic coronary patients aged 35 to 70. Coronary patients showed elevated blood vasopressin, particularly in the presence of frequently recurring anginal attacks. There was no significant difference in vasopressin levels of patients with and without attendant essential hypertension, those with atherosclerotic and postinfarction cardiosclerosis, or in relation to body weight. Insulin, cortisol, adrenocorticotrophic and thyrotrophic hormones were significantly increased, and tri-iodothyronine and total thyroxine, significantly decreased, in coronary patients as compared to the controls.
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PMID:[Vasopressin content of the blood in ischemic heart disease patients and its interrelation with other hormones]. 302 Mar 3

Pulmonary circulation hemodynamics were studied in 175 patients with essential hypertension (EH), coronary disease (CD), atherosclerotic and post-infarction cardiosclerosis and combinations thereof. Pulmonary hemodynamic disorders were found both in cases of EH and CD, being more pronounced in EH patients. When the two diseases are combined, changes reflecting the state of pulmonary hemodynamics are more marked than those occurring in patients with EH or CD alone. When combined, EH and CD mutually aggravate each other's clinical course and symptomatology.
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PMID:[Hemodynamics of pulmonary circulation in patients with hypertension complicated by chronic ischemic heart disease]. 686 83

A total of 75 patients with proved weak sinus node syndrome (WSNS) were examined. In many cases, WSNS was found to accompany cardiovascular diseases, such a coronary disease, myocarditic cardiosclerosis and essential hypertension. Sinus node dysfunction is often combined with signs of disorder in other departments of the hearts conductive system. A screening for WSNS should incorporate a combination of diagnostic procedures, of which Holter's ECG monitoring and electrophysiological investigation of the heart's conductivity are the most reliable and informative.
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PMID:[Clinico-electrocardiographic criteria of heart rhythm disorders in the sick sinus syndrome]. 717 23

An open study of efficiency and safety of atarax (hydroxisine) enrolled 55 outpatients (23 males and 32 females, mean age 45.91 +/- 1.91) with generalized anxious and somatoform disorders running as cardioneurosis as well as nosogenic reactions (maladaptation), manifestations of cardiovascular pathology (acute myocardial infarction, angina of effort functional class II-III, postinfarction cardiosclerosis, essential hypertension in 5, 13, 2 and 5 patients, respectively). The patients received atarax for 28 days (daily dose 50 mg). The course was completed in 54 patients. In 47 of them, the overall score value by Hamilton Anxiety Scale dropped by 10 scores, the reduction being more obvious in patients with somatic anxiety. Hydroxysine is well tolerated and safe both in patients with somatic pathology and those with cardiovascular disorders.
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PMID:[Therapy of cardio-neurotic diseases in general practice: clinical experience with atarax]. 1009 6

Four hundred and nineteen elderly and old patients with pulmonary tuberculosis were examined. One hundred and ninety six patients were found to have an active tuberculous process and contaminant diseases: essential hypertension in 20.7%, functional classes II-III angina pectoris in 55.6%, postinfarct cardiosclerosis in 23.7%. Hypertrophy of the right cardiac cavities was frequently accompanied with that of the left ones (38.1%). Respiratory diseases caused by comorbidity were prevalent among acid-alkali balance disorders. Metabolic disturbances were detected in 90 (21%) patients. Evaluation of pulmonary and cardiac functions by the analysis of acid-alkali balance, gases, blood, and ECG in geriatric patients allows pathogenetic therapy to be timely and soundly.
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PMID:[Pulmonary and cardiac functions in patients with pulmonary tuberculosis]. 1075 Apr 25

Microcirculatory disorders (MD) and hemostasis (HS) were studied in patients with influenza and acute respiratory viral infection (ARVI). The patients also suffered from ischemic heart disease (IHD), essential hypertension (EH) and diabetes mellitus (DM). Among 241 patients 63.9% were middle-aged and old. 45 patients under 60 years of age without coexisting diseases served control. In acute influenza and ARVI the majority of the postcapillary veins and capillaries were affected with sludge syndrome, there were marked perivascular and vascular changes. Convalescence was accompanied with reduced permeability and intravascular aggregation of erythrocytes, microvessels improved tonicity. HS responded to the acute infections with depression of fibrinolysis, in convalescence platelet aggregation activated. IHD patients had disseminated intravascular red cell aggregation, slowing of the microflow, hypercoagulation. Patients with postmyocardial infarction cardiosclerosis (PIC) had more severe affection of microcirculation and hemostasis in convalescence. In hypertensive patients microcirculation and hemostasis were similar to those with IHD. In diabetics platelet aggregation improved but sludge phenomenon and slow blood flow persisted. Thus, ARVI for IHD, EH DM patients are a risk factor for the disease aggravation. In influenza and ARVI, IHD patients, especially with PIC and EH are contraindicated active physical exercise, intake of dysaggregant drugs is desirable. Diabetics should take drugs improving blood rheology early in acute period of ARVI.
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PMID:[Microcirculatory and hemostatic disturbances in patients with influenza and respiratory infections aggravated with coexisting diseases]. 1101 27

Analyzed were data of longitudinal studies of health and peripheral blood of AF pilots and navigators at the age of 20, 25, 30, 35, 40 and 45. The survey of 846 men 30 years and older was conducted in two 5-yr cycles. In this cohort, 329 had diagnosed neurocirculatory dystonia (NCD), vegetovascular dystonia, and class I essential hypertension. Sixty nine men were afflicted with myocardium dystrophy or cardiosclerosis. The dispersion analysis provided evidence that 15 to 5 years prior to establishment of the NCD diagnosis hemoglobin first increases and then decreases. The dispersion analysis applied to the data of repeated measurement attested to the predictive meaning of the hemoglobin rise and decrease. Results support the hypothesis according to which hemoglobin is but a stable individual risk factor but reflects pre-clinic developments in organism.
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PMID:[Hemoglobin as a predictor of cardiovascular problems]. 1198 25

The study of predictors of the development of arrhythmia in elderly age people with IHD is an important task requiring the thorough investigation. The presence of late potentials of ventricles (LPV) is considered presently as one of the most highly informative parameters indicating an electrical inhomogeneity of myocardium, which would result in cardiac rhythm disturbance. The presence of early, late ventricle potentials as well as a dispersion of QT, QRS and T intervals are believed to be the predictors of arrhythmia along with other indices. The study focused on determining a frequency of such predictors among patients of 60-74 y.o. with various clinical picture of IHD. 300 patients were observed: 120 of them with IHD, 100--additionally having essential hypertension, 60--PICS (postinfarction cardiosclerosis), 20--HF. 20 people aged 60-89 formed the control group. The registration of LPV, EPV as well as QT, QRS and T dispersion was carried out by means of Megacart electrocardiograph (produced by "Siemens" company, Germany). The findings are the following: 48 % of the patients with IHD were found with LPV, 33%--with EPV (early potentials of ventricles). LPV is also more frequently met in the patients with IHD complicated with heart failure (HF) and hypertension; dispersion of QRS and T is for sure higher in patients with IHD and HF.
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PMID:[High resolution electrocardiogram in the diagnosis of risk of the cardiac rhythm disorder development in elderly patients with ischemic heart disease]. 1705 4

The authors analyzed the medical records of 1414 patients aged 60 +/- 14 years, who were examined in a specialized cardiological clinic within a one-year period. Among the patients, 41.2% complained of dyspnea; the number of women with dyspnea prevailed over the number of men. Dyspnea was caused by chronic heart failure in 42.2% of patients, by transient myocardial ischemia in 12.3% of patients, and by paroxysmal tachyarrhythmia in 6.3% of patients. In 45.6% of the patients, mostly in women, significant non-cardial factors were revealed: obstructive or restrictive respiratory failure (20.6%), obesity (14.7%), thyroid gland dysfunction (3.9%), pulmonary arterial thromboembolism, anemia etc. A combination of two or more etiological factors took place in 22.6% of cases. The reason for respiratory discomfort remained unclear in 21.3% of the patients, mostly women. Symptom-limited load test with gas analysis (ergospirometry) was performed in 70 patients with dyspnea of unclear origin. According to its results, in 75% of elderly patients with essential hypertension and postinfarction cardiosclerosis, who did not have significant systolic dysfunction, restrictive diastolic dysfunction, valvular disorder, or atrial fibrillation, dyspnea was caused by hyperventilation, obesity, and respiratory pathology.
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PMID:[Chronic dyspnea in cardiological patients: prevalence and etiology]. 1768 90


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