Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The mural thickness of fetal stem arteries of 3rd order was assessed morphometrically in 50 placentae from each of the 'toxaemia', normal pregnancy and acute fetal distress groups. Several clinical maternal and fetal variables and the syncytial sprout proliferation of the placentae were correlated with the morphometric findings. The results show that: (1) there was a significant reduction in the ratio of lumen-to-whole-diameter of the fetal arteries in 'toxaemia' as compared with the two other groups; (2) the mean lumen-to-whole-diameter ratio also differed between regions of the placenta in all groups, the most marked reduction being in the parachorial region and the least prominent in the parabasal zone; (3) no significant differences in the mean diameter ratio were found among the three sub-groups of the toxaemic pregnancies, i.e., the preeclampsia, essential hypertension and renal disease group; and (4) there was an inverse relationship between the lumen-to-whole-diameter ratios and the syncytial sprout counts in the toxaemic group.
Placenta
PMID:Morphometric studies of fetal placental stem arteries in hypertensive disorders ('toxaemia') of pregnancy. 402 51

An electron-optical study of the placenta in essential hypertension indicates that the morphological changes seen in this disease are qualitatively very similar to those found in placentae from pre-eclamptic women: these changes are accentuated if pre-eclampsia is superimposed on essential hypertension. It is therefore suggested that the abnormalities seen in placentae from hypertensive women are due solely to ischaemia. The extent and degree of ischaemic damage suffered by the placenta is essential hypertension were, however, much less marked and extensive than in placentae from pre-eclamptic patients whilst in placentae from cases of essential hypertension complicated by pre-eclampsia there was less evidence of ischaemic damage than in placentae from cases of pre-eclampsia or comparable severity developing in previously normotensive women. It is suggested that the placenta is able to adapt to a state of chronic ischaemia in a manner that it is not able to do in late onset ischaemia and that the adaptive mechanisms adopted not only limit ischaemic damage but also afford protection to the placenta against the effects of superimposed pre-eclampsia.
Placenta
PMID:An ultrastructural and ultrahistochemical study of the human placenta in maternal essential hypertension. 727 74

Placenta lipoprotein lipase (LPL) activity as well as serum VLDL and placenta lipids composition were determined in pregnant hypertensive women at term. 46 patients aged from 29 +/- 2 years with gravidic hypertension (HTA-G) and 38 patients with essential hypertension (HTA-E) aged 30 +/- 1 years were compared with 20 normotensive women aged 27 +/- 1 years. Serum triacylglycerols (TG) concentrations were 1.3-fold higher in the both hypertensive patients compared with controls. However, serum phospholipids (PL) and total cholesterol (TC) values were similar in the three groups. VLDL mass and their apolipoproteins, unesterified cholesterol (UC) and cholesteryl esters (CE) contents were significantly increased in hypertensive women compared with controls. In HTA-G and HTA-E patients, respectively. TG-VLDL concentrations were increased by +43% and +36% compared with those of controls (P < 0.01). In placenta, the values were lower 2.2- and 1.9-fold for TG, 2.8 and 2.5-fold for PL and two- and threefold for TC, in HTA-G and HTA-E patients than in controls. Placenta LPL activity was 2.7-fold higher in HTA-G and HTA-E patients compared with that of controls. In conclusion, although placenta LPL activity is higher it is not permit a decrease of serum TG-VLDL on the one hand, and an increase of placenta ability in TG storage on the other hand.
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PMID:[Gestational or essential hypertension in pregnant women limits the capacity to stock triglycerides by the placenta despite raised lipoprotein-lipase activity]. 1706 43