Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have studied serum glycyl-prolyl-p-nitroanilidase (GPNAase) activity and its distribution in various parts of the body in patients with acute myocardial infarction, chronic ischemic heart disease, valvular heart disease with or without congestive heart failure and essential hypertension. Serum GPNAase activity in patients with acute myocardial infarction was significantly lower as long as 12 days after the onset as compared with normal controls. The serum enzyme activity in patients with congestive heart failure was also significantly lower than that of controls and there was a tendency of its gradual decrease with the progress of the disease. There was no significant difference between the activity in control group and that in age-matched patients with essential hypertension. There was no significant change of the activity in patients with chronic ischemic heart disease. The GPNAase activities in sera obtained from various parts of the body by cardiac catheterization were essentially similar.
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PMID:Glycyl-prolyl-p-nitroanilidase (GPNAase) activity in cardiovascular diseases. 47 Jan 43

Independent replication is vital for study findings drawn from Electronic Health Records (EHR). This replication study evaluates the relationship between seasonal effects at birth and lifetime cardiovascular condition risk. We performed a Season-wide Association Study on 1,169,599 patients from Mount Sinai Hospital (MSH) to compute phenome-wide associations between birth month and CVD. We then evaluated if seasonal patterns found at MSH matched those reported at Columbia University Medical Center. Coronary arteriosclerosis, essential hypertension, angina, and pre-infarction syndrome passed phenome-wide significance and their seasonal patterns matched those previously reported. Atrial fibrillation, cardiomyopathy, and chronic myocardial ischemia had consistent patterns but were not phenome-wide significant. We confirm that CVD risk peaks for those born in the late winter/early spring among the evaluated patient populations. The replication findings bolster evidence for a seasonal birth month effect in CVD. Further study is required to identify the environmental and developmental mechanisms.
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PMID:Replicating Cardiovascular Condition-Birth Month Associations. 2762 41