Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085580 (essential hypertension)
 14,686 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Intravenous injections of calcium gluconate and pentagastrin (CPG) or TRH were compared as secretagogues for calcitonin (CT) in screening for medullary thyroid carcinoma (MTC) in multiple endocrine neoplasia type IIA (MEN IIA). Administration of CPG resulted in a prompt increase in plasma CT in all five patients with MTC studied, one of whom had a normal baseline value (peak 412-371,000 ng/l, 636-4847% above basal). TRH produced a rise in plasma CT levels only in MTC patients with elevated basal values; the magnitude of increase was less than that observed with CPG (peak 168-17,200 ng/l, 113-180% above basal). CT levels did not rise above 300 ng/l with either test in four unaffected first-degree relatives of MEN IIA patients, three subjects with sporadic unilateral phaeochromocytomas and five controls with essential hypertension. CPG remains the CT secretagogue of choice in screening for MTC in MEN II A.
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PMID:A comparison of calcium pentagastrin and TRH tests in screening for medullary carcinoma of the thyroid in MEN IIA. 197 77

Prostaglandins are naturally occurring compounds which are easily separable from other biologically active substances because of its acidic lipid nature. They are divided into 4 series, the A, B, E, and Falpha series, which differ in the structure of the characteristic 5-membered ring. Prostaglandins play a role in the following reproductive functions: 1) conception; 2) luteolysis; 3) menstruation; and 4) parturition. It has also been proposed that Prostaglandin A may be the natriuretic hormone, the circulating hormone which controls sodium reabsorption by the kidney. The experiments of Lee and Ferguson in which prostaglandins inhibited PAH uptake by rabbit renal cortex slices in vitro support this view. Prostaglandins are also implicated 1) in the fluid transfer in the gut; 2) as causative agents of diarrhea that accompanies medullary carcinoma of the thyroid or neural crest tumors; 3) in reducing blood pressure in humans with essential hypertension; 4) in fatty acid metabolism, including lipolysis; and 5) as mediators of the inflammatory response. Further research in prostaglandins will establish the validity of the proposed physiologic or pathologic functions of prostaglandins.
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PMID:Functions of prostaglandins. 458 48

An 81-year-old woman presented with a history of essential hypertension for eight years and an asymptomatic multinodular goiter that had been incidentally discovered on neck ultrasonography two years ago and an-isohypoechoic mass lesion located adjacent to the right lobe inferior pole of the thyroid gland. Parathyroid adenoma or lymphadenopathy were the differential diagnosis. After two years, the endocrine surgeon decided to operate her multinodular goiter and her probably benign lesion. Intraoperatively, the blood pressure and pulse rate increased markedly and intravenous antihypertensive treatment was administered. She was discharged after blood pressure control. A 2 mm micromedullary thyroid carcinoma with C-cell hyperplasia located on the left lobe of the thyroid was detected. The aforementioned mass lesion was also reported as typical cervical paraganglioma. Because of concomitant medullary thyroid carcinoma with C-cell hyperplasia and paraganglioma the patient was subjected to genetic counseling and molecular testing for hereditary cancer syndromes. A variation of the succinate dehydrogenase gene D (SDHD) NM_003002.3: c.325C> T (Gln109Term) has been reported as the disease-causing mutation. Herein we present a case diagnosed for neck paraganglioma and medullary thyroid carcinoma after an intraoperative hypertensive crisis.
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PMID:A PATIENT WITH AN ATYPIC NECK MASS LESION. 3302 41