Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0085437 (bacterial meningitis)
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Human Gene/Protein
retinoic acid early transcript 1E 12.9
dynactin 4 10.9
EXOC6B 10.4
MYL5 10.4
TM-8 9.8
PRSP 9.4
FAIM3 9.4
Acetyl-CoA hydrolase 9.0
2'5' oligoadenylate synthetase 8.6
H. influenzae 8.6
receptor for advanced glycosylation end products 8.5
FAIM 8.2
chemokine (C-C motif) ligand 3 8.1
ITGAX 8.1
RALBP1 8.1
MSK2 7.9
ARHGAP5 7.9
FAIM2 7.9
lifeguard 7.9
transforming growth factor-beta-activated kinase 1 7.7
FTH 7.7
HLA-B52 7.6
CARD8 7.6
TPO protein 7.6
acyloxyacyl hydrolase 7.6
NG1 7.6
Complement protein 7.5
ELL2 7.4
CD 16 7.3
lactic acid dehydrogenase 7.3
IRAK-2 7.3
LTA4H 7.3
MNX1 7.3
ribosomal protein S20 7.2
K100 7.1
Caspase-14 7.1
CSF 7.1
CSF2 7.1
IQ motif containing GTPase activating protein 1 7.0
PISP 6.9
PRES 6.9
AP50 6.7
Beta-2-microglobulin 6.6
C2 protein 6.5
claudin 5 6.5
CSF1 6.4
CD14 antigen 6.4
CFLAR 6.4
SPN 6.3
heparin binding protein 6.3
TBM 6.2
RLIP76 6.2
white cell 6.2
mannan-binding protein 6.2
TEF-1 6.1
ITGB2 6.1
component D 6.1
CISH 6.0
DRw11 5.9
19A 5.9
HEXB 5.9
TNF-alpha converting enzyme 5.8
renal dipeptidase 5.8
DP3 5.8
PYGM 5.7
PEPT2 5.7
RBM 5.7
Granulocyte-colony stimulating factor 5.6
GBS 5.6
ORF 1 5.6
Decoy receptor 3 5.6
B-5 5.5
stromelysin-3 5.5
P97 5.5
GCH1 5.5
CASP1 5.5
Alpha-1-antitrypsin 5.4
COL11A1 5.4
heparin-binding protein 5.4
GCS 5.3
more...
Disease
CMV radiculopathy 12.9
necrosis; cerebral 12.9
bacterial meningitis 12.9
Other bacterial meningitis 12.9
Staphylococcal meningitis 12.5
Proteus meningitis 11.9
Sphenoidal sinusitis 11.9
Recurrent bacterial meningitis 11.7
Suppurative labyrinthitis 11.6
viral meningitis 11.5
Klebsiella meningitis 11.5
Streptococcus pneumoniae meningitis 11.4
West Nile virus meningoencephalitis 11.4
Pseudomonas meningitis 11.4
Staphylococcus aureus meningitis 11.3
Streptococcal meningitis 11.1
Mycobacterium tuberculosis meningitis 11.1
Haemophilus influenzae meningitis 11.1
Neonatal meningitis 11.0
Salmonella meningitis 10.9
Haemophilus meningitis 10.7
Escherichia coli meningitis 10.7
Listeria meningitis 10.6
infectious meningitis 10.5
Anaerobic meningitis 10.4
gray syndrome 10.4
HIB meningitis 10.4
CNS candidiasis 10.4
meningococcal meningitis 10.3
bacterial CNS infection 10.1
Chemical meningitis 9.9
aseptic meningitis 9.7
meningitis 9.6
Fungal meningitis 9.6
Cytomegalovirus encephalitis 9.6
Neuroinfections 9.6
enterovirus meningitis 9.4
Salmonella sepsis 9.3
Cerebral vasculitis 9.2
Intracranial mass 9.1
ventriculitis 9.1
mumps meningitis 9.1
Subdural empyema 9.1
Disseminated strongyloidiasis 9.0
Tonsillar herniation 8.9
Ventriculitis 8.9
infectious encephalitis 8.9
Currarino triad 8.8
Meningocele 8.8
Herpes simplex 1 8.8
Neisseria infections 8.8
Tuberculous meningitis 8.8
petrositis 8.7
Streptococcus suis infection 8.7
ependymitis 8.6
cholangiectasis 8.6
ZD1 8.6
Necrotizing arteritis 8.5
Infections of the central nervous system 8.4
meningococcal infection 8.4
nervous system infection 8.4
Haemophilus 8.3
Drug-induced immune thrombocytopenia 8.3
Shunt infection 8.3
Viral encephalitis 8.3
labyrinthitis 8.2
primary amebic meningoencephalitis 8.2
meningococcemia 8.2
cerebral abscess 8.2
Salmonella enteritis 8.1
brain abscess 8.1
arteriosclerotic dementia 8.1
Vanishing bile duct syndrome 8.1
Enterococcal infections 8.1
Mollaret's meningitis 8.0
Acute mastoiditis 8.0
viral pharyngitis 7.9
Waterhouse-Friderichsen syndrome 7.9
Cerebrospinal fluid rhinorrhea 7.9
leptomeningitis 7.9
more...
Symptom
Brudzinski's sign 11.8
Bulging fontanelle 11.4
Nuchal rigidity 10.9
Kernig's sign 10.5
neck stiffness 9.6
meningism 9.4
sinus congestion 7.6
consciousness disturbance 7.4
rhinorrhea 6.5
Acute urinary retention 6.0
Signs and Symptoms 5.8
generalized rash 5.8
photophobia 5.6
Neurologic symptoms 5.4
prostration 5.4
impaired motor coordination 5.4
abnormal breathing 5.2
fever of unknown origin 5.1
otalgia 5.0
athetosis 4.9
hyperesthesia 4.9
visual hallucination 4.8
headache 4.7
lethargy 4.6
No adverse effect 4.6
Physical findings 4.6
seizures 4.4
neurological disability 4.1
neck pain 4.0
hemiplegia 4.0
vomiting 4.0
tachypnea 4.0
ataxic gait 3.8
paraparesis 3.8
sore throat 3.8
decreased appetite 3.8
Fluctuation 3.7
rales 3.6
ENT 3.6
ophthalmoplegia 3.6
limb pain 3.6
leg pain 3.5
torticollis 3.3
muscle cramps 3.1
dysesthesia 3.1
nausea 3.0
sleepiness 2.9
myoclonus 2.9
dizziness 2.9
flank pain 2.8
catatonia 2.8
abnormal gait 2.8
stridor 2.8
facial pain 2.8
diarrhea 2.7
dental pain 2.7
back pain 2.7
tingling 2.6
tonic-clonic seizure 2.6
ataxia 2.6
nasal discharge 2.5
chills 2.5
paresis 2.4
hypotonia 2.4
anosmia 2.4
sciatica 2.3
myalgia 2.3
hypocapnia 2.2
abdominal discomfort 2.2
numbness 2.2
hypothermia 2.2
neuralgia 2.2
incoordination 2.2
respiratory distress 2.1
vertigo 2.1
hip pain 2.1
memory loss 2.1
cyanosis 2.1
sneezing 2.0
agitation 2.0
more...
Drug
Thalomid 9.8
Amikin 9.4
Amikacin sulfate 8.7
PAPM/BP 8.6
MEPM 8.6
Iron dextran 8.5
Phenoxymethylpenicillin 8.3
CTRX 8.2
Dexamethasone sodium phosphate 8.2
CDZM 7.9
Meropenem 7.9
Garamycin 7.8
Meropenem 7.8
Rocephin 7.8
CZON 7.7
Claforan 7.3
Pantopaque 7.2
Nafcillin 7.0
Temocillin 6.9
Florfenicol 6.8
CSF 6.7
ampicillin 6.7
Ceftazidime 6.6
7-Nitroindazole 6.5
MINO 6.5
Zovirax 6.4
Zinat 6.0
Mezlocillin 5.9
Adenosine deaminase 5.8
CFS 5.6
Daclizumab 5.4
Pefloxacin 5.3
Bactrim 5.3
Augmentin 4.9
Augmentin 4.8
Amoxicillin 4.7
CPZ 4.6
AC2 4.5
CDX 4.5
Acyclovir 4.5
Trimethoprim-sulfamethoxazole 4.4
SBT 4.3
Doyle 4.3
Ofloxacin 4.3
Aminoguanidine 4.2
LCM 4.2
NBT 4.2
LCM 4.2
Hyaluronidase 4.1
OMP 4.1
CVA 4.1
Hyaluronidase 4.0
Adalimumab 3.9
Dakar 3.9
AMC 3.7
Glide 3.6
CCL 3.6
EPI 3.5
IPM 3.4
VCR 3.3
Alliance 3.1
DEX 3.1
Itraconazole 3.0
ENT 2.9
Doxycycline 2.9
ROC 2.8
RFP 2.7
pyridoxal phosphate 2.6
Fluconazole 2.6
Lovastatin 2.6
Gleevec 2.5
Prednisolone 2.4
IFN-beta 2.4
Simvastatin 2.3
CPR 2.2
Activin 2.2
Kenyan 2.2
Bevacizumab 2.2
Check 2.0
Propofol 1.9
more...
Enzyme
IgA1 protease 7.9
carboxypeptidase II 7.7
acyloxyacyl hydrolase 7.6
NAAT 7.5
acetyl-CoA hydrolase 7.1
IgA protease 7.0
lactic acid dehydrogenase 6.4
lactic acid dehydrogenase 6.4
penicillin binding protein 6.2
stromelysin-3 5.9
lactic acid dehydrogenase 5.7
lambda exonuclease 5.3
endo-N 5.1
beta-lactamase 4.8
LuxS 4.7
LTA4 hydrolase 4.7
murein hydrolase 4.7
ADH 4.6
matrix metalloproteinase 9 4.4
TACE 4.3
4-epimerase 4.2
adenosine deaminase 4.1
adenosine deaminase 4.1
indoleamine 2,3-dioxygenase 4.1
MIP 3.9
MMP-3 3.8
GTP cyclohydrolase I 3.6
transpeptidase 3.4
alpha-mannosidase 3.4
sialyltransferase 3.4
sialyltransferase 3.4
sialyltransferase 3.4
phosphoglucose isomerase 3.2
nitrite reductase 3.1
nitrite reductase 3.1
nitrite reductase 3.1
GAS 3.0
lysin 2.9
MMP 2.9
xanthine dehydrogenase 2.7
enolase 2.7
caspase-1 2.6
ceruloplasmin 2.6
alcohol dehydrogenase 2.6
lysozyme 2.5
lactate dehydrogenase 2.4
dipeptidyl peptidase IV 2.2
glutamine synthetase 2.2
aldolase 2.2
AOR 2.2
cytochrome oxidase 2.2
hexosaminidase 2.2
elastase 2.1
PAM 2.1
adenylate kinase 2.0
collagenase 1.8
matrix metalloproteinase 2 1.8
NOS 1.7
caspase-3 1.6
beta-glucuronidase 1.6
BMT 1.6
sialidase 1.5
asparaginase 1.5
myosin light chain kinase 1.5
PARP 1.5
xanthine oxidase 1.5
AST 1.4
creatine kinase 1.3
NO synthase 1.3
granzyme B 1.3
superoxide dismutase 1.2
neuraminidase 1.1
endonuclease 1.1
heme oxygenase 0.9
glutamate dehydrogenase 0.9
glutamate dehydrogenase 0.8
thromboplastin 0.8
glutamate dehydrogenase 0.8
alanine aminotransferase 0.8
hyaluronidase 0.8
more...
Compound
T 39 9.9
Chloramphenicol succinate 9.8
Cefotaxime sodium 8.9
4 PA 8.8
Cefotaxime 8.3
Ceftriaxone 8.2
Moxalactam 7.7
Cefuroxime 7.3
Cefoperazone 7.2
Mezlocillin 7.1
Nafcillin 7.0
Ceftizoxime 7.0
Flucloxacillin 7.0
C6H12O6 6.9
Cefpodoxime 6.8
Ceftazidime 6.6
Cefmetazole 6.6
Cefadroxil 6.6
Methacrylic acid 6.6
Cephalothin 6.4
Penicillin 6.2
DAHP 6.1
Palmitoylethanolamide 6.1
Dexamethasone 6.1
SP 1 6.1
Geigy 6.1
Juglone 6.1
Tazobactam 6.0
Fosfomycin 6.0
Penicillin 6.0
M 3 5.8
C 10 5.8
C 10 5.8
BRL 5.8
Rifampicin 5.7
4-pentenoic acid 5.7
Trovafloxacin 5.7
Daptomycin 5.7
MBC 5.6
Cefamandole 5.6
COA 5.6
Rifabutin 5.6
Cefpirome 5.6
MBC 5.6
Cefepime 5.5
Vancomycin 5.5
SHA 5.4
Cefixime 5.4
Sulbactam 5.3
Netilmicin 5.3
NDMA 5.1
Amikacin 5.0
neopterin 4.9
Mannitol 4.9
S 1 4.9
Sudan I 4.9
Linezolid 4.9
Amoxicillin 4.8
Mannitol 4.8
Polymyxin B 4.7
Belt 4.7
Betamethasone 4.6
T 1 4.5
Cefazolin 4.5
Wellcome 4.5
Xanthine 4.5
VPM 4.4
CPZ 4.4
DBM 4.4
Aztreonam 4.4
DBM 4.4
Desmopressin 4.4
TBE 4.3
Sumatriptan 4.3
Lactate 4.3
LCR 4.3
TACE 4.3
Pentoxifylline 4.3
Cefoxitin 4.2
Lorazepam 4.2
more...