Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0085437 (
bacterial meningitis
)
4,038
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Apart from potential roles in anti-tumor surveillance, the
TNF-related apoptosis-inducing ligand
(
TRAIL
) has important regulatory functions in the host immune response. We studied antiinflammatory effects of endogenous and recombinant
TRAIL
(rTRAIL) in experimental meningitis. Following intrathecal application of pneumococcal cell wall, a TLR2 ligand, we found prolonged inflammation, augmented clinical impairment, and increased apoptosis in the hippocampus of
TRAIL
(-/-) mice. Administration of rTRAIL into the subarachnoid space of
TRAIL
(-/-) mice or reconstitution of hematopoiesis with wild-type bone marrow cells reversed these effects, suggesting an autoregulatory role of
TRAIL
within the infiltrating leukocyte population. Importantly, intrathecal application of rTRAIL in wild-type mice with meningitis also decreased inflammation and apoptosis. Moreover, patients suffering from
bacterial meningitis
showed increased intrathecal synthesis of
TRAIL
. Our findings provide what we believe is the first evidence that
TRAIL
may act as a negative regulator of acute CNS inflammation. The ability of
TRAIL
to modify inflammatory responses and to reduce neuronal cell death in meningitis suggests that it may be used as a novel antiinflammatory agent in invasive infections.
...
PMID:TRAIL limits excessive host immune responses in bacterial meningitis. 1757 Nov 63
