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Query: UMLS:C0085437 (bacterial meningitis)
 4,038 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Among 809 patients with bacterial meningitis persistent pleocytosis greater than 60 white blood, cells/mm3, after 10 days or more of therapy, was found in 25 patients and persistent hypercervicospinal fluid proteins greater than 70 mg/dl in 24. In 14 patients there was an association of these disturbances. All cases, except one, were adequately treated. Persistent pleocytosis and hyper-cervicospinal fluid proteins, uncommon inmeningococcal meningitis, were frequent in pneumococcal and more frequent in Haemophilus influenzae meningitis. In pneumococcal and Haemophilus influenzae meningitis the incidence of neurologic sequelae was greater in patients with persistent pleocytosis and hyper-cervicospinal fluid proteins than without them. In adequately treated patients, persistent pleocytosis or hyper-cervicospinal fluid proteins alone cannot be used as an indication of prolonging or changing therapy of bacterial meningitis.
Sem Hop
PMID:[Evaluation of the criteria used for the interruption of treatment in bacterial meningitis (persistent pleocytosis and hyper-cervicospinal fluid proteins (author's transl)]. 624 85

In managing bacterial meningitis, the essential rule, stated by Chabbert, is to achieved antibiotic concentrations in the CSF which exceed the minimal bactericidal concentration (MBC) Several factors must be considered, related either to the microorganism itself (virulence, sensitivity, density of the cultured sample, resistance to metabolites, inactivation of the antibiotic by purulent CSF) or to the patient (initial site of infection, immunologic deficiency, csf clearance). As to the antibiotic liposolubility, free plasma fraction, and route of administration, are the factors which affect it's passage towards the CSF.
Sem Hop 1982 Feb 04
PMID:[Bacteriologic and pharmacodynamic basis for treating bacterial meningitis (author's transl)]. 627 5

Retrospective study of 14 cases of Staphylococcus aureus meningitis and of data from the literature shows that this as yet infrequent disease which carries a high mortality rate (40%) is always related to neurosurgery, primary or iatrogenic septicemia, or local infection, usually in the lumbar area (spinal, abscess, spondylitis). The major clinical problem is the search for the meningeal lead point of Staphylococcus aureus penetration, whose eradication is more essential than in usual bacterial meningitis. Prognosis is mainly dependent upon the eventual existence of associated severe septicemia. Antibiotics active on Peni-M resistant Staphylococcus aureus and meningeal infection are reviewed.
Sem Hop 1983 Dec 22
PMID:[Purulent Staphylococcus aureus meningitis]. 631 57