Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0085437 (bacterial meningitis)
 4,038 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The gas chromatographic analysis of short-chain fatty acids is of great significance in the rapid diagnosis of anaerobic infections and bacterial meningitis. A new analytical method is presented detecting lactic acid without prior derivatisation in addition to volatile fatty acids in the aqueous phase directly. Lactic acid levels greater than 30 mg/dl are measured in cerebrospinal fluids of patients with acute bacterial meningitis. The sole detection of acetic acid in concentrations higher than 20 mg/dl indicates aerobes in clinical materials. A high correlation exists between the determination of n-butyric acid as well as iso-valeric acid and the occurrence of anaerobic bacteria.
 ...
PMID:[Direct gas chromatography analysis of volatile fatty acids and lactic acids in microbiological diagnosis]. 269 46

Pathophysiological studies in bacterial meningitis in man have been limited by clinical variability and the necessity for immediate therapy. After the development of a reliable animal model of pneumococcal meningitis, we studied respiration and circulation in 25 anesthetized New Zealand white rabbits during untreated pneumococcal meningitis and in 33 healthy controls. In meningitis, we found increased lactic acid in cerebrospinal fluid (CSF). Increased ventilation, perhaps due to CSF lactic acid accumulation, resulted in respiratory alkalosis; the concomitant lowering of Pco(2) acted as a homeostatic mechanism to restore pH toward normality in the CSF. Hyperventilation increased with the duration of the illness. Cardiac output was also increased with decreased peripheral vascular resistance but with only slight reduction in mean systemic and pulmonary arterial pressures. In the final hour of life, peripheral vascular resistance fell further; ventilation declined and then abruptly ceased while cardiac activity continued. Lactic acid accumulation in the CSF, found in both experimental and human pneumococcal meningitis, may cause the hyperventilation found in this disease and may contribute to death.
 ...
PMID:Effect of experimental pneumococcal meningitis on respiration and circulation in the rabbit. 415 1

Analysis of cerebrospinal fluid lactic acid levels in 62 patients suspected of having meningitis was performed. Lactic acid was measured enzymatically using lactic acid dehydrogenase with the liberation of NADH. In a control (no meningitis) group, 46 children had a mean cerebrospinal fluid lactic acid level of 14.7 +/- 2.2 mg/dl; 3 with febrile seizure had a mean lactic acid level of 33.5 +/- 0.98 mg/dl. In 9 cases of bacterial meningitis, the mean lactic acid level was 54.8 +/- 16.8 mg/dl. In 3 patients of aseptic meningitis, the mean lactic acid level was 34.5 +/- 1.0 mg/dl. Serial lactate determination was done in three patients and they were well correlated with the clinical response and other cerebrospinal fluid findings. These data suggest that the determination of cerebrospinal fluid lactic acid may be of diagnostic value in differentiating between bacterial and aseptic meningitis.
 ...
PMID:Diagnostic use of cerebrospinal fluid lactic acid levels in meningitis. 658 98

Lactic acid concentration has been determined in the cerebrospinal fluid (CSF) of 715 patients suffering from various neurological diseases. It was found to be most often elevated in cases of ischemic cerebral infarction, cerebral contusion, arteriosclerotic dementia, metastatic encephalitis, bacterial meningitis, menigiosis carcinomatosa and after epileptic seizures. In fewer cases lactate levels were increased with brain tumors, encephalitis, viral meningitis and radiculitis. Diagnostic relevance of CSF lactic acid determination is discussed with regard to ischemic cerebral disorders, differential diagnosis of viral and bacterial meningitis and for the confirmation of epileptic seizures.
 ...
PMID:[Importance of cerebrospinal fluid lactate determination in neurological diseases]. 686 67

The stability of lactic acid in cerebrospinal fluid specimens from children with or without infections of the central nervous system was determined. Twenty-six patients were studied. These were ten children with bacterial meningitis, nine with aseptic meningitis and seven without any inflammation of the central nervous system. The specimens were left at room temperature and lactic acid concentration was measured at sequential intervals: 15 minutes, and two, six and 24 hours following their collection. A decline in the concentration was noticed in all specimens. However, the most marked total reduction in lactic acid concentration was noted in specimens obtained from patients with bacterial meningitis. The average reduction in that group was 5 mg/dl after two hours, 11 mg/dl after six hours and 18 mg/dl following 24 hours. Lactic acid concentration remained unchanged up to 72 hours in specimens frozen at -20 degrees C. To prevent misleading results, it is recommended that cerebrospinal fluid specimens not be left at room temperature for prolonged periods of time prior to lactic acid determination.
 ...
PMID:Stability of lactic acid in cerebrospinal fluid specimens. 706 19