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Query: UMLS:C0085437 (bacterial meningitis)
 4,038 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Despite the availability of potent antibiotics, bacterial meningitis is still a major clinical problem. Mortality is high, and up to a third of survivors are left with neurologic sequelae that may range from mild behavioral disorders to mental retardation or deafness. New therapeutic approaches to meningeal inflammation, however, are reducing the neurologic risks.
Hosp Pract (Off Ed) 1991 Jan 15
PMID:Mediators of meningitis: therapeutic implications. 189 48

In many pediatric infectious disease programs, ceftriaxone or cefotaxime is now the preferred drug for bacterial meningitis caused by H. influenzae, meningococci, and pneumococci. Ceftriaxone reaches a high bactericidal titer in the cerebrospinal fluid and persists at the site of infection longer than any other beta-lactam antibiotic. Short-course, once-daily therapy with ceftriaxone requires more study; currently, many pediatricians administer the agent twice daily for suspected or proven meningitis. Given the association of sequelae with prolongation of positive CSF cultures, ceftriaxone's rapid bactericidal activity is an advantage, which may require an adjunctive agent to block the inflammatory response due to antibiotic-induced release of endotoxin and other cell wall components. As empiric therapy, ceftriaxone is effective in infants and children three months to 18 years old. It is not yet recommended in neonates, because of concerns about bilirubin displacement. Thus, infants up to three months of age should receive ampicillin plus cefotaxime. In adults, ceftriaxone is effective therapy for presumed bacterial meningitis but must be combined with ampicillin initially, since L. monocytogenes meningitis cannot be excluded in most cases until CSF culture results are available.
Hosp Pract (Off Ed) 1991 Sep
PMID:Ceftriaxone in treatment of serious infections. Meningitis. 191 17

Children with bacterial meningitis are ideal candidates for outpatient parenteral antibiotic therapy; most recover from the acute infection within five days and do not require skilled nursing observation of neurologic status during the entire course of therapy. Before discharge, the child should be afebrile, show a good response to therapy, and demonstrate no neurologic abnormalities.
Hosp Pract (Off Ed) 1993 Jul
PMID:Outpatient parenteral antibiotic therapy. Management of serious infections. Part II: Amenable infections and models for delivery. Meningitis. 832 22