Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0085437 (
bacterial meningitis
)
4,038
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The value of
phosphohexose isomerase
(
EC 5.3.1.9
) determination in the CSF in the diagnosis of meningitis was tested under routine conditions. In 48 patients with untreated
bacterial meningitis
, enzyme activity concentrations between 40 and 2335 U/l were measured, whereas the highest
phosphohexose isomerase
activity concentration in 92 patients with viral meningitis was 34 U/l. Lysis of the CSF leukocytes with Triton X-100 resulted in a substantial increase of
phosphohexose isomerase
activity. In
bacterial meningitis
these values increased to 200 to 7000 U/l, but remained under 150 U/l in viral meningitis. The raised enzyme activities are derived from the leukocytes and appear to reflect their functional and metabolic state. The information provided by the leukocyte morphology can thus be appreciably extended by
phosphohexose isomerase
determination.
...
PMID:Clinical significance and source of raised catalytic activities of phosphohexose isomerase in the CSF in meningitis. 355 79
The diagnostic value of determining
phosphohexose isomerase
(PHI, E.C. 5.3.1.9) activity in the CSF for differential diagnosis of bacterial and viral meningitis was investigated. In 29 patients with untreated
bacterial meningitis
, a mean enzyme activity of 511 U/1 was found, whereas a value 19 U/1 was found in 61 cases of viral meningitis. The reference range with an upper limit of 6 U/1 was determined from CSF samples from 163 "healthy" children. The high diagnostic sensitivity and specificity of 100% and 99.5% respectively make PHI a sensitive differential diagnostic parameter in meningitis.
...
PMID:Phosphohexose isomerase in cerebrospinal fluid in meningitis. 740 13
