Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085437 (bacterial meningitis)
 4,038 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Dynamic examinations of the activity of glutamate-aspartate and glutamate-alanine aminotransferases (AST, ALT), fructose diphosphate aldolase and alkaline phosphatase in the cerebrospinal fluid (CSF) were carried out in 512 patients (14 groups) suffering from viral and bacterial meningitis in the acute period, as well as in reconvalescents. The activity of the CSF enzymes was also determined in 70 healthy subjects. It was found that in the acute period of meningitis the activity of the CSF enzymes (mostly of the aminotransferases) rose, this rise being greater in meningococcal and tuberculous meningitis than in the viral one. In reconvalescents the activity of the aminotransferases dropped, and that of aldolase and alkaline phosphatase got normal. The activity of the blood serum enzymes showed no substantial changes. The differences in the activity of the enzymes may serve as a criterion for diagnostic differentiation of meningitis.
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PMID:[Serum and cerebrospinal fluid enzyme spectra in meningitis and their differential diagnostic value]. 707 18

To evaluate the effects of bacterial meningitis on blood and CSF parameters, an experiment was conducted with five Iranian crossbred male calves. Blood and CSF samples were collected 3 times within a 5-day interval before the administration of bacteria for obtaining control values. Following the injection of E. coli, K12 into the cerebrospinal fluid from the lumbosacral space, samples were collected and clinical signs of meningitis were observed. Blood and CSF samples were obtained from the meningitis group 3 times at 1, 3, and 5 days post injection. The treatment of the infected calves using lincospectin and tetracycline was carried out immediately after the onset of clinical signs. After the treatment, blood and CSF samples were obtained 3 times during a 5-day period. Following the induction of meningitis, the number of WBCs, neutrophils, eosinophils and monocytes significantly increased (P < 0.05). However, the percent of lymphocytes decreased significantly (P < 0.05). The concentrations of glucose, potassium and activity of AST, LDH, CK significantly increased (P < 0.05). In contrast, the concentrations of phosphorous, sodium and magnesium significantly decreased (P < 0.05). Furthermore, following the induction of meningitis, the CSF was slightly xantochromic and turbid. The concentrations of protein, cholesterol, phosphorous, potassium, the activities of AST, LDH, CK, and the cell numbers in the CSF increased significantly (P < 0.05). In contrast, the concentration of glucose and pH in the CSF decreased significantly (P < 0.05). This study showed that bacterial meningitis can have profound effects on blood and CSF parameters which enable one to reach diagnosis.
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PMID:Evaluation of hematological, serum biochemical and cerebrospinal fluid parameters in experimental bacterial meningitis in the calf. 912 83