Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0085437 (bacterial meningitis)
4,038 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bacterial meningitis is a medical emergency requiring prompt recognition and evaluation and urgent initiation of appropriate antibacterial therapy. However, early recognition of severe bacterial infection including bacterial meningitis is a challenge in infants. Two clinical forms are basically observed in infants and young children: firstly, clinical meningitis which is characterized by fever, usually greater than 39 degrees C, and poorly specific gastrointestinal signs such as refusal of feeding and/or vomiting; irritability, abnormal crying, bulging fontanel, unusual generalized seizures occurring before six months of age and lasting more than 10 min should draw the clinician's attention and lead him/her to perform a lumbar puncture and initiate antibiotics; secondly, severe sepsis which is characterized by tachycardia, cold and/or mottled limbs and sometimes leg pain which should suggest a meningococcal disease; it is quite urgent to administer rapid fluid loading and antibiotic treatment while postponing lumbar puncture before the septic cascade evolves towards septic shock, extensive hemorrhagic rash, and ischemic limbs. Given the relative frequency of viral self-limiting diseases and rarity of serious bacterial infections, guidelines were published to guide the clinician's decision when dealing with a febrile infant. However, an alternative to these guidelines was recently suggested with a more clinically oriented decision-making attitude appearing as efficient while limiting hospitalizations.
...
PMID:[Clinical signs suggestive of bacterial meningitis in infants]. 1940 42

We present a case of arachnoiditis and an intrathecal hematoma after an epidural blood patch. A 24-year-old parturient underwent an epidural blood patch three days after an accidental dural puncture during epidural labor analgesia. Four days later, the patient developed severe lower back pain, bilateral leg pain, persistent headache and fever. Bacterial meningitis was initially suspected and antibiotics started. Lumbar magnetic resonance imaging was performed and showed an intrathecal hematoma, with no blood in the epidural space. This report briefly reviews the few cases in the literature of arachnoiditis caused by an intrathecal hematoma and discusses the mechanism which resulted in blood in the subarachnoid space.
...
PMID:Intrathecal hematoma and arachnoiditis mimicking bacterial meningitis after an epidural blood patch. 2868 21

Salmonella meningitis is a rare infection, particularly in adults. We report the case of a 75-year-old female with a history of rheumatoid arthritis on TNF-antagonist immunosuppressive therapy who initially presented to the hospital for management of back and leg pain and was ultimately diagnosed with bacterial meningitis secondary to Salmonella species infection. She was treated with ceftriaxone with slow improvement in neurological function. Though the source of infection was never clearly identified from multiple imaging studies, we suspect the severity of her presentation was due to her history of TNF-antagonist use.
...
PMID:The Risk of Immunosuppression: A Case of Salmonella Meningitis. 2995 26