Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0085437 (
bacterial meningitis
)
4,038
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Streptococcus agalactiae
(
Sta
) of Lancefield group B is the primary etiological agent of
bacterial meningitis
in Nile tilapia and newborn humans. Thus, the study of this disease is of fundamental importance for aquaculture and human medicine. Additionally, elucidation of the mechanisms involved in the host-pathogenic response is important for the success of new therapies. In the present study, we elucidated important aspects of the innate immune response in the brain tissue of Nile tilapia (
Oreochromis niloticus
) infected by
Sta
. The neuroinflammatory process in the meninges started with the migration of
MHC class II
and CD68 + cells, production of TNF-alpha, and the effective immune response to
Sta
was mediated by the increased iNOs+. In conclusion, the present study brings a partial understanding of the pathophysiological and neuroinflammatory mechanisms in meningitis in
Sta
infected tilapia, enabling important advances in the therapy of this disease as well as the possibility of using this biological model to understand human meningitis.
...
PMID:Meningitis Caused by
Streptococcus agalactiae
in Nile Tilapia (
Oreochromis niloticus
): Infection and Inflammatory Response. 3323 16
