Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085437 (bacterial meningitis)
 4,038 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 43-year-old black man had recurrence of acute bacterial meningitis caused by Neisseria meningitidis. He had had three previous episodes of acute meningitis, starting at age 27 years. The patient's serum was found to have an undetectable level of the sixth component of complement. Congenital absence of one of the terminal proteins in the complement system impairs a patient's ability to eradicate bacteria, and increases susceptibility to recurring infections caused by meningococci and other Neisseria species. Though the serum of complement-deficient patients promotes normal opsonization of bacteria, it is unable to kill meningococci directly. The currently available meningococcal vaccine may augment type-specific antibody, but it does not correct the underlying complement deficiency. The role of self-administered antibiotics in preventing recurrent Neisseria infection remains uncertain.
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PMID:Recurrent meningitis in a black man. 291 51

An 18-year-old man suffered from recurrent bacterial meningitis. Investigation of the complement system revealed deficiency of the 8th complement component (C8) in the patient and his sister. Genetic defects of the terminal complement components C5 to C8 predispose to Neisseria infections, probably due to a lack in bacteriolytic activity. It is to be noted that 1 year ago the patient had been hospitalized for a culture-proved pneumococcal meningitis.
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PMID:[Recurrent meningitis in familial deficiency of the 8th component of the complement system]. 358 74