Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085437 (bacterial meningitis)
 4,038 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Among 121 cases of bacterial meningitis (age 2 months to 12 years; mean, 35 months) treated over a 3-year period, Neisseria meningitidis was the most common pathogen (33 per cent), then Haemophilus influenzae (32 per cent) and Streptococcus pneumoniae (15 per cent). In the H. influenzae group, 95 per cent were aged below 2 years. Overall mortality was 12 per cent: higher in the S. pneumoniae (17 per cent) and less common organism (21 per cent) groups. Neurological sequelae in 21 (20 per cent) of the 106 survivors included hearing impairment in 17 and quadriparesis in eight. Meningitis caused by S. pneumoniae contained a significantly higher proportion of children with neurological morbidity (P = 0.0128). The addition of dexamethasone treatment during the third year produced an apparent but not significant trend towards less mortality (P = 0.7568), fewer neurological sequelae (P = 0.3401) and less hearing impairment (P = 0.3903). Despite the availability of effective chemotherapy, bacterial meningitis will remain an important cause of high mortality and considerable morbidity.
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PMID:Bacterial meningitis: still a cause of high mortality and severe neurological morbidity in childhood. 853 Dec 66

Meningitis is an uncommon complications of head trauma. Vasculitis in bacterial meningitis is seen in 9%-25% of adults. Neurological deficits in bacterial meningitis are seen in about one-third of children. Isolated cranial nerve palsies are common, whereas major deficits such as hemiparesis and quadriparesis are rare. We describe a case of a 7-year-old boy who had post-traumatic meningitis complicated with quadriparesis and severe vasculitis of bilateral anterior and posterior circulation with moyamoya vasculopathy.
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PMID:Pyogenic Meningitis Complicated with Extensive Central Nervous System Vasculitis and Moyamoya Vasculopathy. 3027 71

Meningitis or meningoencephalitis is a known complication of scrub typhus. Focal neurological deficits are rarely reported including hemiparesis, quadriparesis and isolated cranial nerve palsies. Here we are reporting a 24 years female who presented with fever, headache, ptosis, diplopia, facial deviation and unsteadiness of gait due to scrub typhus. Scrub typhus can present as acute or subacute meningitis complicated by multiple cranial palsies and cerebellitis. Hence it needs to be differentiated from acute bacterial meningitis and tubercular meningitis as delay in diagnosis and treatment will affect the morbidity and mortality.
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PMID:Scrub Meningitis Complicated by Multiple Cranial Nerve Palsies and Cerebellitis. 3157 66