Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085437 (bacterial meningitis)
 4,038 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A family with autosomal dominant inheritance of sacral agenesis is described. Ten members were affected; four had associated presacral teratomas and anterior sacral meningoceles, giving rise to serious complications in three, including bacterial meningitis, local recurrence of teratoma and perianal sepsis. Three of those with presacral masses presented initially with anorectal anomalies. Other associated abnormalities included tethering of the cord, hydrocephalus, duplex ureter, hydronephrosis, vesicoureteric reflux, neurogenic bladder, bicornuate uterus, rectovaginal fistula and hereditary spherocytosis. Early diagnosis and surgical excision of a presacral mass is advised to prevent future morbidity and mortality.
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PMID:Hereditary sacral agenesis with presacral mass and anorectal stenosis: the Currarino triad. 205 99

Chemical meningitis is a medical condition characterised by sterile meningitis that usually develops in certain patients after neurosurgical procedures. Its acute clinical course and standard laboratory findings are indistinguishable from those of bacterial meningitis. We hereby describe a case who presented with clinico-investigatory profile suggestive of acute bacterial meningitis. Patient showed good response to standard antibiotics and steroids, but deteriorated on stopping steroids. MRI brain showed hyperintense signal in the frontal horns of lateral ventricle on T1 weighted images suggesting presence of fat. MRI spine confirmed presence of ruptured teratoma in lumbo-sacral region which had caused chemical meningitis. Patient responded well to steroid therapy. Tumour histopathology confirmed the diagnosis of mature cystic teratoma.
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PMID:Chemical meningitis caused by spontaneous rupture of spinal teratoma. 2279 19