Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085437 (bacterial meningitis)
 4,038 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

CSF of a 4-month-old boy with prolonged, meningococcal meningitis revealed oligoclonal immunoglobulin G about 10 weeks after hospital admission. These proteins persisted for at least 4 months. In contrast to this child, a further 10 infants and young children with bacterial meningitis, whose CSF was examined between 4 weeks and 6 3/4 months subsequent to onset of the disease, showed no such abnormality. Since the presented boy was the only patient treated with a corticosteroid, his altered immune reaction could be related to the immunosuppressive effect of this drug.
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PMID:Occurrence of M-proteins in the CSF of a child with prolonged meningococcal meningitis. 9 3

The passage of 6-[(R)-2-[3-methylsulfonyl-2-oxo-imidazolidine-1-carboxamido]-2-phenyl-acetamido)-penicillanic acid sodium salt (mezlocillin, Baypen), into the CSF was studied in 9 patients with symptoms of acute meningitis, presumed to be of viral origin. The antibiotic was given as a single 5 g dose i.v. over 30 min. The CSF/serum concentration ratio of mezlocillin showed a variation from 0 to 10.7%. The antibiotic could be effective in the treatment of bacterial meningitis caused by ampicillin-resistant strains of Haemophilus influenzae and by most Enterobacteriaceae, provided these results will be confirmed by a study now in progress. In one patient suffering from meningococcal meningitis this concentration ratio varied between 72% (day 3) and 54% (day 12).
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PMID:Cerebrospinal fluid penetration of mezlocillin. 54 3

Between 1 January 1971 and 31 December 1975, 1,333 patients with acute bacterial meningitis were admitted to the meningitis ward of the Abbassia Fever Hospital. These cases are tabulated by distribution of diagnosis, seasonal distribution, age and sex distribution, and age-specific case fatality ratio. Results are compared with those of other large series of cases reported from other parts of the world. The annual incidence of acute bacterial meningitis in Egypt varies widely. Recent data show this to be due to variations in the incidence of group A meningococcal meningitis. The study includes the declining phase of an epidemic of that disease and confirms a previously reported finding that the case fatality ratio in group A meningococcal meningitis varies inversely with the annual number of cases.
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PMID:Acute bacterial meningitis in Cairo, Arab Republic of Egypt, 1 January 1971 through 31 December 1975. 71 26

An analysis of 219 confirmed cases of bacterial meningitis among Navajo Indians during a 5-year period, July 1, 1968, through June 30, 1973, revealed that 56 percent were caused by Haemophilus influenzae, 26 percent by Neisseria meningitidis, 6 percent by Mycobacterium tuberculosis, and 6 percent by other organisms. The annual incidence of H. influenzae meningitis (17.7 per 100,000 persons) and that of pneumococcal meningitis (8.0 per 100,000) were much higher than the rates for these diseases reported from other population groups. The annual incidence of meningococcal meningitis (2.0 per 100,000) was similar to that found elsewhere. There was an ususual concentration of cases during the first year of life; 78 percent of H. influenzae, 64 percent of pneumococcal, and 50 percent of meningococcal meningitis occurred during this time. However, bacterial meningitis during the first month of life was not frequent (0.29 per 1,000 live births). Case fatality rates were similar to those reported for other population groups.
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PMID:Bacterial meningitis in Navojo Indians. 82 72

Several different sources of data, including statutory notifications, were used to identify cases of acute bacterial meningitis in childhood in a defined population. Only half the cases of meningococcal meningitis and less than one quarter of ofther types of bacterial meningitis had been notified. Notified cases differed from the remainder with respect to causative organism, age, outcome, and type of hospital of admission. Thus notifications are an unreliable measure of incidence for this disease, and studies of infectious disease based on notified cases alone should be interpreted with considerable reserve. It is suggested that infectious-disease surveillance should be both clinical and microbiological and that data from different sources need to co-ordinated. The reason for reporting each disease (or organism) should be specified and and reviewed periodically.
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PMID:Completeness of statutory notification for acute bacterial meningitis. 95 48

Review of 102 admissions of children (one month to seven years of age) with bacterial meningitis is presented. 46 of the patients (45%) had been treated previously with one or more antibiotics. Previous treatment made culture of CSF negative in a statistically significant (p less than 0.001) number of cases, mainly in meningococcal meningitis. There were no significant differences in the levels of CSF glucose, proteins and WBC's between both groups. A decrease of the percentage PMN/lymphocytes was found in the CSF of the partially treated group. In 7 out of 102 no more than two CSF pathological findings were present. In 5 or 7 CSF cultures were positive. In the other two there were pathological changes in CSF even with correct dosage of previous antibiotics. In 4 patients with positive cultures and little changes in CSF on admission, LP after 48 hours of correct treatment showed an increase in the alterations of CSF. This could mean that previous low dosage antibiotic treatment should not modify CSF findings enough not to make correct diagnosis.
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PMID:[CSF. changes in partially treated bacterial meningitis (author's transl)]. 126

A retrospective study was carried out at Dayanand Medical College & Hospital, Ludhiana (Punjab) during the period from January 1985 to June 1990 to know the incidence of meningococcal meningitis. Meningococcal etiology was established in 170 (49.41%) cases out of 344 cases of bacterial meningitis. Out of 170 cases of meningococcal meningitis, 74 (43.52%) were positive only by smear examination, 90 (52.94%) were positive both by smear as well as culture and there were six (3.52%) cases which were positive only by culture. The organisms were sensitive to most of the common antibiotics including penicillin, chloramphenicol, ampicillin and sulphadiazine.
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PMID:Meningococcal meningitis in Ludhiana. 134 24

A 20-year old man had three episodes of meningococcal meningitis. Complement assays showed a complete deficiency of the seventh component of the complement system. This case emphasizes the need to perform complement assays in young patients with recurrent bacterial meningitis.
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PMID:[Recurrent Neisseria meningitidis meningitis associated with homozygote complement C7 fraction deficiency]. 160 43

A case is described of fulminant meningococcal meningitis occurring 1 day after serious head and facial trauma. Although meningococcus is one of the most common causes of bacterial meningitis in general, it is distinctly rare as a cause of posttraumatic meningitis. A review of the literature is included.
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PMID:Posttraumatic meningococcal meningitis: case report. 174 45

533 cases of bacterial meningitis diagnosed in the province of Cordoba over a period of seven years are analyzed. 53.7% of the cases are in males, with 71.2% of the cases being detected in children under 14 (p less than 0.001). Greater incidence has been observed in Cordoba city than in the province, with a direct relationship being between morbidity and population density. The months with lower average temperature account for 45.6 por 100 of all the diagnosed cases of meningitis. By etiology, 51.9% were meningococcal meningitis, followed by meningitis produced by unknown germs (35.3%) and by H. influenzae. The illness developed in 91.3% of cases to a cure, with sequelae in 4.1% and death in 4.4%. Meningitis produced by H: influenzae was what caused most sequelae and that produced by S. pneumoniae was the most lethal. Isolated N. meningitidis presented 100% sensitivity to penicillin and cephalosporins, H. influenzae 91.7% chloramphenicol and only 28.3% to penicillin.
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PMID:[Clinical-epidemiological assessment of bacterial meningitis in the province of Cordoba (1983-1989)]. 180 Nov 71


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